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Review Open Access

Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review)

  • Authors:
    • Jian Xiong
    • Yinshuang Chen
    • Weipeng Wang
    • Jing Sun
  • View Affiliations / Copyright

    Affiliations: Institute of Medical Biotechnology, Suzhou Vocational Health College, Suzhou, Jiangsu 215009, P.R. China, Center for Drug Metabolism and Pharmacokinetics, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, P.R. China
    Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 21
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    Published online on: November 16, 2021
       https://doi.org/10.3892/ol.2021.13139
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Abstract

Serine/arginine‑rich splicing factor 3 (SRSF3; also known as SRp20), an important member of the family of SRSFs, is abnormally expressed in tumors, resulting in aberrant splicing of hub genes, such as CD44, HER2, MDM4, Rac family small GTPase 1 and tumor protein p53. Under normal conditions, the splicing and expression of SRSF3 are strictly regulated. However, the splicing, expression and phosphorylation of SRSF3 are abnormal in tumors. SRSF3 plays important roles in the occurrence and development of tumors, including the promotion of tumorigenesis, cellular proliferation, the cell cycle and metastasis, as well as inhibition of cell senescence, apoptosis and autophagy. SRSF3‑knockdown significantly inhibits the proliferation and metastatic characteristics of tumor cells. Therefore, SRSF3 may be suggested as a novel anti‑tumor target. The other biological functions of SRSF3 and its regulatory mechanisms are also summarized in the current review.
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Copy and paste a formatted citation
Spandidos Publications style
Xiong J, Chen Y, Wang W and Sun J: Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review). Oncol Lett 23: 21, 2022.
APA
Xiong, J., Chen, Y., Wang, W., & Sun, J. (2022). Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review). Oncology Letters, 23, 21. https://doi.org/10.3892/ol.2021.13139
MLA
Xiong, J., Chen, Y., Wang, W., Sun, J."Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review)". Oncology Letters 23.1 (2022): 21.
Chicago
Xiong, J., Chen, Y., Wang, W., Sun, J."Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review)". Oncology Letters 23, no. 1 (2022): 21. https://doi.org/10.3892/ol.2021.13139
Copy and paste a formatted citation
x
Spandidos Publications style
Xiong J, Chen Y, Wang W and Sun J: Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review). Oncol Lett 23: 21, 2022.
APA
Xiong, J., Chen, Y., Wang, W., & Sun, J. (2022). Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review). Oncology Letters, 23, 21. https://doi.org/10.3892/ol.2021.13139
MLA
Xiong, J., Chen, Y., Wang, W., Sun, J."Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review)". Oncology Letters 23.1 (2022): 21.
Chicago
Xiong, J., Chen, Y., Wang, W., Sun, J."Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review)". Oncology Letters 23, no. 1 (2022): 21. https://doi.org/10.3892/ol.2021.13139
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