Open Access

Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review)

  • Authors:
    • Jian Xiong
    • Yinshuang Chen
    • Weipeng Wang
    • Jing Sun
  • View Affiliations

  • Published online on: November 16, 2021     https://doi.org/10.3892/ol.2021.13139
  • Article Number: 21
  • Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Serine/arginine‑rich splicing factor 3 (SRSF3; also known as SRp20), an important member of the family of SRSFs, is abnormally expressed in tumors, resulting in aberrant splicing of hub genes, such as CD44, HER2, MDM4, Rac family small GTPase 1 and tumor protein p53. Under normal conditions, the splicing and expression of SRSF3 are strictly regulated. However, the splicing, expression and phosphorylation of SRSF3 are abnormal in tumors. SRSF3 plays important roles in the occurrence and development of tumors, including the promotion of tumorigenesis, cellular proliferation, the cell cycle and metastasis, as well as inhibition of cell senescence, apoptosis and autophagy. SRSF3‑knockdown significantly inhibits the proliferation and metastatic characteristics of tumor cells. Therefore, SRSF3 may be suggested as a novel anti‑tumor target. The other biological functions of SRSF3 and its regulatory mechanisms are also summarized in the current review.
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January-2022
Volume 23 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xiong J, Chen Y, Wang W and Sun J: Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review). Oncol Lett 23: 21, 2022
APA
Xiong, J., Chen, Y., Wang, W., & Sun, J. (2022). Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review). Oncology Letters, 23, 21. https://doi.org/10.3892/ol.2021.13139
MLA
Xiong, J., Chen, Y., Wang, W., Sun, J."Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review)". Oncology Letters 23.1 (2022): 21.
Chicago
Xiong, J., Chen, Y., Wang, W., Sun, J."Biological function and molecular mechanism of SRSF3 in cancer and beyond (Review)". Oncology Letters 23, no. 1 (2022): 21. https://doi.org/10.3892/ol.2021.13139