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Article Open Access

Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis

  • Authors:
    • Shu-Ling Hsieh
    • Jia-Huei Li
    • Cheng-Di Dong
    • Chiu-Wen Chen
    • Chih-Chung Wu
  • View Affiliations / Copyright

    Affiliations: Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan, R.O.C., Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan, R.O.C., Department of Food and Nutrition, Providence University, Taichung 43301, Taiwan, R.O.C.
    Copyright: © Hsieh et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 44
    |
    Published online on: December 9, 2021
       https://doi.org/10.3892/ol.2021.13162
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Abstract

Carnosine (β‑alanyl‑L‑histidine) is found in beef and fish. The present study aimed to investigate the effects of carnosine on the cell proliferation of human colorectal cancer cells. After human colorectal cancer HCT‑116 cells were treated carnosine for 72 or 96 h, the cell proliferation, apoptosis, autophagy, necroptosis, angiogenesis and the expression of related regulatory molecules were detected using MTT assays, fluorescence image analysis and RT‑qPCR in this study. Treatment of HCT‑116 cells with 5, 10 or 15 mM carnosine for 72 or 96 h significantly decreased cell viability (P<0.05). The mRNA expression of β‑catenin and transcription factor 4 (Tcf‑4) was significantly reduced by 15‑23% and 11‑80%, respectively (P<0.05). When HCT‑116 cells were treated with 15 mM carnosine, the mRNA levels of 1A/1B‑light chain 3 and phosphatidylinositol 3‑kinase were significantly increased by 235% and 249%, respectively (P<0.05). The mRNA level of Beclin‑1 and autophagy levels were significantly increased by 137‑141% in HCT‑116 cells treated with 5, 10 or 15 mM carnosine (P<0.05). Carnosine (15 mM) also increased reactive oxygen species levels and mixed lineage kinase domain‑like protein mRNA expression and depleted ATP levels (P<0.05). The angiogenesis‑regulating molecules vascular endothelial growth factor, epidermal growth factor receptor and hypoxia‑inducible factor 1‑α were all significantly decreased by 10 or 15 mM carnosine treatment. These results showed that carnosine could suppress human colorectal cell proliferation by reducing β‑catenin/Tcf‑4 signaling, inducing autophagy and necroptosis and inhibiting angiogenesis. It was demonstrated that carnosine is a potential compound from dietary food for the future clinical treatment and/or prevention of colorectal cancer.
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View References

1 

Boldyrev AA, Aldini G and Derave W: Physiology and pathophysiology of carnosine. Physiol Rev. 93:1803–1845. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Hipkiss AR, Baye E and de Courten B: Carnosine and the processes of ageing. Maturitas. 93:28–33. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Jain S, Kim ES, Kim D, Burrows D, De Felice M, Kim M, Baek SH, Ali A, Redgrave J, Doeppner TR, et al: Comparative cerebroprotective potential of d- and l-carnosine following ischemic stroke in mice. Int J Mol Sci. 21:30532020. View Article : Google Scholar : PubMed/NCBI

4 

Prokopieva VD, Yarygina EG, Bokhan NA and Ivanova SA: Use of carnosine for oxidative stress reduction in different pathologies. Oxid Med Cell Longev. 2016:29390872016. View Article : Google Scholar : PubMed/NCBI

5 

Caruso G, Fresta CG, Musso N, Giambirtone M, Grasso M, Spampinato SF, Merlo S, Drago F, Lazzarino G, Sortino MA, et al: Carnosine prevents Aβ-induced oxidative stress and inflammation in microglial cells: A key role of TGF-β1. Cells. 8:642019. View Article : Google Scholar : PubMed/NCBI

6 

Bermúdez ML, Seroogy KB and Genter MB: Evaluation of carnosine intervention in the Thy1-aSyn mouse model of Parkinson's disease. Neuroscience. 411:270–278. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Hsieh SL, Hsieh S, Lai PY, Wang JJ, Li CC and Wu CC: Carnosine suppresses human colorectal cell migration and intravasation by regulating EMT and mMP expression. Am J Chin Med. 47:477–494. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Wu CC, Lai PY, Hsieh S, Cheng CC and Hsieh SL: Suppression of carnosine on adhesion and extravasation of human colorectal cancer cells. Anticancer Res. 39:6135–6144. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Zhang Z, Miao L, Wu X, Liu G, Peng Y, Xin X, Jiao B and Kong X: Carnosine inhibits the proliferation of human gastric carcinoma cells by retarding Akt/mTOR/p70S6K signaling. J Cancer. 5:382–389. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Tamaki N, Funatsuka A, Fujimoto S and Hama T: The utilization of carnosine in rats fed on a histidine-free diet and its effect on the levels of tissue histidine and carnosine. J Nutr Sci Vitaminol (Tokyo). 30:541–551. 1984. View Article : Google Scholar : PubMed/NCBI

11 

Gariballa SE and Sinclair AJ: Carnosine: Physiological properties and therapeutic potential. Age Ageing. 29:207–210. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Zhao K, Li Y, Wang Z, Han N and Wang Y: Carnosine protects mouse podocytes from high glucose induced apoptosis through PI3K/AKT and Nrf2 pathways. BioMed Res Int. 2019:43489732019. View Article : Google Scholar : PubMed/NCBI

13 

Lee J, Park JR, Lee H, Jang S, Ryu SM, Kim H, Kim D, Jang A and Yang SR: L-carnosine induces apoptosis/cell cycle arrest via suppression of NF-κB/STAT1 pathway in HCT116 colorectal cancer cells. In Vitro Cell Dev Biol Anim. 54:505–512. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Joshi RK, Kim WJ and Lee SA: Association between obesity-related adipokines and colorectal cancer: A case-control study and meta-analysis. World J Gastroenterol. 20:7941–7949. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Chaabane W, User SD, El-Gazzah M, Jaksik R, Sajjadi E, Rzeszowska-Wolny J and Los MJ: Autophagy, apoptosis, mitoptosis and necrosis: Interdependence between those pathways and effects on cancer. Arch Immunol Ther Exp (Warsz). 61:43–58. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Martinez-Font E, Pérez-Capó M, Ramos R, Felipe I, Garcías C, Luna P, Terrasa J, Martín-Broto J, Vögler O, Alemany R, et al: Impact of Wnt/β-Catenin Inhibition on Cell Proliferation through CDC25A Downregulation in Soft Tissue Sarcomas. Cancers (Basel). 12:25562020. View Article : Google Scholar : PubMed/NCBI

18 

Hikita H, Kodama T, Shimizu S, Li W, Shigekawa M, Tanaka S, Hosui A, Miyagi T, Tatsumi T, Kanto T, et al: Bak deficiency inhibits liver carcinogenesis: A causal link between apoptosis and carcinogenesis. J Hepatol. 57:92–100. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Ahamed M, Akhtar MJ, Siddiqui MA, Ahmad J, Musarrat J, Al-Khedhairy AA, AlSalhi MS and Alrokayan SA: Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells. Toxicology. 283:101–108. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Galati S, Boni C, Gerra MC, Lazzaretti M and Buschini A: Autophagy: A player in response to oxidative stress and DNA damage. Oxid Med Cell Longev. 2019:56929582019. View Article : Google Scholar : PubMed/NCBI

21 

Shimizu S, Yoshida T, Tsujioka M and Arakawa S: Autophagic cell death and cancer. Int J Mol Sci. 15:3145–3153. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Robinson N, Ganesan R, Hegedűs C, Kovács K, Kufer TA and Virág L: Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos. Redox Biol. 26:1012392019. View Article : Google Scholar : PubMed/NCBI

23 

Wu W, Liu P and Li J: Necroptosis: An emerging form of programmed cell death. Crit Rev Oncol Hematol. 82:249–258. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Manda G, Isvoranu G, Comanescu MV, Manea A, Debelec Butuner B and Korkmaz KS: The redox biology network in cancer pathophysiology and therapeutics. Redox Biol. 5:347–357. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, et al: Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling. Autophagy. 7:966–978. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Fulda S: Cell death and survival signaling in oncogenesis. Klin Padiatr. 222:340–344. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Denizot F and Lang R: Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods. 89:271–277. 1986. View Article : Google Scholar : PubMed/NCBI

28 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔC(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Cho YH, Ro EJ, Yoon JS, Mizutani T, Kang DW, Park JC, Il Kim T, Clevers H and Choi KY: 5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation. Nat Commun. 11:53212020. View Article : Google Scholar : PubMed/NCBI

31 

Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y and Kondo S: Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 11:448–457. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Prieto-Domínguez N, Ordóñez R, Fernández A, García-Palomo A, Muntané J, González-Gallego J and Mauriz JL: Modulation of autophagy by sorafenib: Effects on treatment response. Front Pharmacol. 7:1512016. View Article : Google Scholar : PubMed/NCBI

33 

Wu Y, Dong G and Sheng C: Targeting necroptosis in anticancer therapy: Mechanisms and modulators. Acta Pharm Sin B. 10:1601–1618. 2020. View Article : Google Scholar : PubMed/NCBI

34 

Capozzi M, De Divitiis C, Ottaiano A, von Arx C, Scala S, Tatangelo F, Delrio P and Tafuto S: Lenvatinib, a molecule with versatile application: From preclinical evidence to future development in anti-cancer treatment. Cancer Manag Res. 11:3847–3860. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Chao DL, Sanchez CA, Galipeau PC, Blount PL, Paulson TG, Cowan DS, Ayub K, Odze RD, Rabinovitch PS and Reid BJ: Cell proliferation, cell cycle abnormalities, and cancer outcome in patients with Barrett's esophagus: A long-term prospective study. Clin Cancer Res. 14:6988–6995. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Tiwari M: Apoptosis and survival. Indian J Hum Genet. 17:120–125. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Loo G: Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (review). J Nutr Biochem. 14:64–73. 2003.(review). View Article : Google Scholar : PubMed/NCBI

38 

Shi Y and Zhang CJ: The effects of carnosine on high glucose-induced apoptosis of human umbilical vein endothelial cells. Adv Mat Res. 345:365–369. 2011.

39 

Mateyak MK, Obaya AJ and Sedivy JM: c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol Cell Biol. 19:4672–4683. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Tian Y, Wan H and Tan G: Cell cycle-related kinase in carcinogenesis. Oncol Lett. 4:601–606. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Sebio A, Kahn M and Lenz HJ: The potential of targeting Wnt/β-catenin in colon cancer. Expert Opin Ther Targets. 18:611–615. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Sakoguchi-Okada N, Takahashi-Yanaga F, Fukada K, Shiraishi F, Taba Y, Miwa Y, Morimoto S, Iida M and Sasaguri T: Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells. Biochem Pharmacol. 73:1318–1329. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Shan BE, Wang MX and Li RQ: Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 27:604–612. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Ha T, Lou Z, Baek SJ and Lee SH: Tolfenamic acid downregulates β-catenin in colon cancer. Int Immunopharmacol. 35:287–293. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Han D, Cao C, Su Y, Wang J, Sun J, Chen H and Xu A: Ginkgo biloba exocarp extracts inhibits angiogenesis and its effects on Wnt/β-catenin-VEGF signaling pathway in Lewis lung cancer. J Ethnopharmacol. 192:406–412. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Kang R, Zeh HJ, Lotze MT and Tang D: The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18:571–580. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Mizushima N: Autophagy. FEBS Lett. 584:12792010. View Article : Google Scholar : PubMed/NCBI

48 

Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science. 290:1717–1721. 2000. View Article : Google Scholar : PubMed/NCBI

49 

Ertmer A, Huber V, Gilch S, Yoshimori T, Erfle V, Duyster J, Elsässer HP and Schätzl HM: The anticancer drug imatinib induces cellular autophagy. Leukemia. 21:936–942. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Guamán-Ortiz LM, Romero-Benavides JC, Suarez AI, Torres-Aguilar S, Castillo-Veintimilla P, Samaniego-Romero J, Ortiz-Diaz K and Bailon-Moscoso N: Cytotoxic property of Grias neuberthii extract on human colon cancer cells: A crucial role of autophagy. Evid Based Complement Alternat Med. 2020:15653062020. View Article : Google Scholar : PubMed/NCBI

51 

Hsieh LC, Hsieh SL, Chen CT, Chung JG, Wang JJ and Wu CC: Induction of α-phellandrene on autophagy in human liver tumor cells. Am J Chin Med. 43:121–136. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Hsieh SL, Chen CT, Wang JJ, Kuo YH, Li CC, Hsieh LC and Wu CC: Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells. Int J Oncol. 47:2240–2246. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Rong L, Li Z, Leng X, Li H, Ma Y, Chen Y and Song F: Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway. Biomed Pharmacother. 122:1097262020. View Article : Google Scholar : PubMed/NCBI

54 

Galluzzi L, Kepp O, Chan FK and Kroemer G: Necroptosis: Mechanisms and relevance to disease. Annu Rev Pathol. 12:103–130. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Dhuriya YK and Sharma D: Necroptosis: A regulated inflammatory mode of cell death. J Neuroinflammation. 15:1992018. View Article : Google Scholar : PubMed/NCBI

56 

Schenk B and Fulda S: Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death. Oncogene. 34:5796–5806. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Lee YJ, Park KS, Nam HS, Cho MK and Lee SH: Apigenin causes necroptosis by inducing ROS accumulation, mitochondrial dysfunction, and ATP depletion in malignant mesothelioma cells. Korean J Physiol Pharmacol. 24:493–502. 2020. View Article : Google Scholar : PubMed/NCBI

58 

Liu X, Zhang Y, Gao H, Hou Y, Lu JJ, Feng Y, Xu Q, Liu B and Chen X: Induction of an MLKL mediated non-canonical necroptosis through reactive oxygen species by tanshinol A in lung cancer cells. Biochem Pharmacol. 171:1136842020. View Article : Google Scholar : PubMed/NCBI

59 

Jackson AL, Zhou B and Kim WY: HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer. Expert Opin Ther Targets. 14:1047–1057. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Lichtenberger BM, Tan PK, Niederleithner H, Ferrara N, Petzelbauer P and Sibilia M: Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell. 140:268–279. 2010. View Article : Google Scholar : PubMed/NCBI

61 

Huang KF, Zhang GD, Huang YQ and Diao Y: Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway. Int Immunopharmacol. 12:334–341. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Zheng HL, Yang J, Hou Y, Sun B, Zhang Q, Mou Y, Wand L and Wu C: Oligomer procyanidins (F2) isolated from grape seeds inhibits tumor angiogenesis and cell invasion by targeting HIF-1α in vitro. Int J Oncol. 46:708–720. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Quinn PJ, Boldyrev AA and Formazuyk VE: Carnosine: Its properties, functions and potential therapeutic applications. Mol Aspects Med. 13:379–444. 1992. View Article : Google Scholar : PubMed/NCBI

64 

Hipkiss AR: Carnosine, a protective, anti-ageing peptide? Int J Biochem Cell Biol. 30:863–868. 1998. View Article : Google Scholar : PubMed/NCBI

65 

Sampathkumar SG, Jones MB, Meledeo MA, Campbell CT, Choi SS, Hida K, Gomutputra P, Sheh A, Gilmartin T, Head SR, et al: Targeting glycosylation pathways and the cell cycle: Sugar-dependent activity of butyrate-carbohydrate cancer prodrugs. Chem Biol. 13:1265–1275. 2006. View Article : Google Scholar : PubMed/NCBI

66 

Fahie K and Zachara NE: Molecular functions of glycoconjugates in autophagy. J Mol Biol. 428:3305–3324. 2016. View Article : Google Scholar : PubMed/NCBI

67 

Cheng WK and Oon CE: How glycosylation aids tumor angiogenesis: An updated review. Biomed Pharmacother. 103:1246–1252. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Hipkiss AR, Michaelis J and Syrris P: Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett. 371:81–85. 1995. View Article : Google Scholar : PubMed/NCBI

69 

Hipkiss AR and Gaunitz F: Inhibition of tumour cell growth by carnosine: some possible mechanisms. Amino Acids. 46:327–337. 2014. View Article : Google Scholar : PubMed/NCBI

70 

Li Y, Wang K, Chen L, Zhu X and Zhou J: Quantification of mRNA Levels Using Real-Time Polymerase Chain Reaction (PCR). Methods Mol Biol. 1406:73–79. 2016. View Article : Google Scholar : PubMed/NCBI

71 

Deribe YL, Pawson T and Dikic I: Post-translational modifications in signal integration. Nat Struct Mol Biol. 17:666–672. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hsieh S, Li J, Dong C, Chen C and Wu C: Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis. Oncol Lett 23: 44, 2022.
APA
Hsieh, S., Li, J., Dong, C., Chen, C., & Wu, C. (2022). Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis. Oncology Letters, 23, 44. https://doi.org/10.3892/ol.2021.13162
MLA
Hsieh, S., Li, J., Dong, C., Chen, C., Wu, C."Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis". Oncology Letters 23.2 (2022): 44.
Chicago
Hsieh, S., Li, J., Dong, C., Chen, C., Wu, C."Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis". Oncology Letters 23, no. 2 (2022): 44. https://doi.org/10.3892/ol.2021.13162
Copy and paste a formatted citation
x
Spandidos Publications style
Hsieh S, Li J, Dong C, Chen C and Wu C: Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis. Oncol Lett 23: 44, 2022.
APA
Hsieh, S., Li, J., Dong, C., Chen, C., & Wu, C. (2022). Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis. Oncology Letters, 23, 44. https://doi.org/10.3892/ol.2021.13162
MLA
Hsieh, S., Li, J., Dong, C., Chen, C., Wu, C."Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis". Oncology Letters 23.2 (2022): 44.
Chicago
Hsieh, S., Li, J., Dong, C., Chen, C., Wu, C."Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis". Oncology Letters 23, no. 2 (2022): 44. https://doi.org/10.3892/ol.2021.13162
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