|
1
|
Zheng J and Gao P: Toward normalization of
the tumor microenvironment for cancer therapy. Integr Cancer Ther.
18:15347354198623522019. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Bissell MJ and Hines WC: Why don't we get
more cancer? A proposed role of the microenvironment in restraining
cancer progression. Nat Med. 17:320–329. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Meng X, Yang Y, Zhou L, Zhang L, Lv Y, Li
S, Wu Y, Zheng M, Li W, Gao G, et al: Dual-responsive molecular
probe for tumor targeted imaging and photodynamic therapy.
Theranostics. 7:1781–1794. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Stockwell BR, Angeli JP, Bayir H, Bush AI,
Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, et al:
Ferroptosis: A regulated cell death nexus linking metabolism, redox
biology, and disease. Cell. 171:273–285. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta
R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS,
et al: Ferroptosis: An iron-dependent form of nonapoptotic cell
death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Dolma S, Lessnick SL, Hahn WC and
Stockwell BR: Identification of genotype-selective antitumor agents
using synthetic lethal chemical screening in engineered human tumor
cells. Cancer Cell. 3:285–296. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Sato H, Tamba M, Ishii T and Bannai S:
Cloning and expression of a plasma membrane cystine/glutamate
exchange transporter composed of two distinct proteins. J Biol
Chem. 274:11455–11458. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Kandasamy P, Gyimesi G, Kanai Y and
Hediger MA: Amino acid transporters revisited: New views in health
and disease. Trends Biochemical Sci. 43:752–789. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Stipanuk MH, Dominy JE Jr, Lee JI and
Coloso RM: Mammalian cysteine metabolism: New insights into
regulation of cysteine metabolism. J Nutr. 136 (Suppl
6):1652S–1659S. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Combs JA and DeNicola GM: The
non-essential amino acid cysteine becomes essential for tumor
proliferation and survival. Cancers (Basel). 11:6782019. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lu SC: Regulation of glutathione
synthesis. Mol Aspects Med. 30:42–59. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Friedmann JP, Schneider M, Proneth B,
Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A,
Eggenhofer E, et al: Inactivation of the ferroptosis regulator Gpx4
triggers acute renal failure in mice. Nat Cell Biol. 16:1180–1191.
2014. View
Article : Google Scholar : PubMed/NCBI
|
|
13
|
Yang WS, SriRamaratnam R, Welsch ME,
Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji
AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by
GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Scalise M, Pochini L, Pingitore P, Hedfalk
K and Indiveri C: Cysteine is not a substrate but a specifific
modulator of human ASCT2 (SLC1A5) transporter. FEBS Lett.
589:3617–3623. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Hanigan MH and Ricketts WA: Extracellular
glutathione is a source of cysteine for cells that express
gamma-glutamyl transpeptidase. Biochemistry. 32:6302–6306. 1993.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Zerbib E, Arif T, Shteinfer-Kuzmine A,
Chalifa-Caspi V and Shoshan-Barmatz V: VDAC1 silencing in cancer
cells leads to metabolic reprogramming that modulates tumor
microenvironment. Cancers (Basel). 13:28502021. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Lei G, Zhang Y, Koppula P, Liu X, Zhang J,
Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, et al: The role of
ferroptosis in ionizing radiation-induced cell death and tumor
suppression. Cell Res. 30:146–162. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Fotiadis D, Kanai Y and Palacín M: The
SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med.
34:139–158. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Koppula P, Zhang Y, Shi J, Li W and Gan B:
The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell
dependency on glucose by exporting glutamate. J Biol Chem.
292:14240–14249. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Pakos-Zebrucka K, Koryga I, Mnich K,
Ljujic M, Samali A and Gorman AM: The integrated stress response.
EMBO Rep. 17:1374–1395. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Kilberg MS, Shan J and Su N:
ATF4-dependent transcription mediates signaling of amino acid
limitation. Trends Endocrinol Metab. 20:436–443. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Ye P, Mimura J, Okada T, Sato H, Liu T,
Maruyama A, Ohyama C and Itoh K: Nrf2-and ATF4-dependent
upregulation of xCT modulates the sensitivity of T24 bladder
carcinoma cells to proteasome inhibition. Mol Cell Biol.
34:3421–3434. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Jiang L, Kon N, Li T, Wang SJ, Su T,
Hibshoosh H, Baer R and Gu W: Ferroptosis as a p53-mediated
activity during tumour suppression. Nature. 520:57–62. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Clemons NJ, Liu DS, Duong CP and Phillips
WA: Inhibiting system xC (−) and glutathione biosynthesis-a
potential Achilles'hell in mutant-p53. Mol Cell Oncol.
4:e13447572017. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zhu JH, De Mello RA, Yan QL, Wang JW, Chen
Y, Ye QH, Wang ZJ, Tang HJ and Huang T: MiR-139-5p/SLC7A11 inhibits
the proliferation, invasion and metastasis of pancreatic carcinoma
via PI3K/Akt signaling pathway. Biochim Biophys Acta Mol Basis Dis.
1866:1657472020. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Drayton RM, Dudziec E, Peter S, Bertz S,
Hartmann A, Bryant HE and Catto JW: Reduced expression of miRNA-27a
modulates cisplatin resistance in bladder cancer by targeting the
cystine/glutamate exchanger SLC7A11. Clin Cancer Res. 20:1990–2000.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wu Y, Sun X, Song B, Qiu X and Zhao J:
MiR-375/SLC7A11 axis regulates oral squamous cell carcinoma
proliferation and invasion. Cancer Med. 6:1686–1697. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Jaenisch R and Bird A: Epigenetic
regulation of gene expression: How the genome integrates intrinsic
and environmental signals. Nat Genet. 33 (Suppl):S245–S254. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Zhang Y, Shi J, Liu X, Feng L, Gong Z,
Koppula P, Sirohi K, Li X, Wei Y, Lee H, et al: BAP1 links
metabolic regulation of ferroptosis to tumour suppression. Nat Cell
Biol. 20:1181–1192. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Sui S, Zhang J, Xu S, Wang Q, Wang P and
Pang D: Ferritinophagy is required for the induction of ferroptosis
by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells.
Cell Death Dis. 10:3312019. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Ogiwara H, Takahashi K, Sasaki M, Kuroda
T, Yoshida H, Watanabe R, Maruyama A, Makinoshima H, Chiwaki F,
Sasaki H, et al: Targeting the vulnerability of glutathione
metabolism in ARID1A defificient cancers. Cancer Cell. 35:177–190.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Liu T, Jiang L, Tavana O and Gu W: The
deubiquitylase OTUB1 mediates ferroptosis via stabilization of
SLC7A11. Cancer Res. 79:1913–1924. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Gu Y, Albuquerque CP, Braas D, Zhang W,
Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, et al: mTORC2
regulates amino acid metabolism in cancer by phosphorylation of the
cystineglutamate antiporter xCT. Mol Cell. 67:128–138. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Kim J and Guan KL: mTOR as a central hub
of nutrient signalling and cell growth. Nat Cell Biol. 21:63–71.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Goji T, Takahara K, Negishi M and Katoh H:
Cystine uptake through the cystine/glutamate antiporter xCT
triggers glioblastoma cell death under glucose deprivation. J Biol
Chem. 292:19721–19732. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Schlageter M, Terracciano LM, D'Angelo S
and Sorrentino P: Histopathology of hepatocellular carcinoma. World
J Gastroenterol. 20:15955–15964. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Cabibbo G, Maida M, Genco C, Antonucci M
and Cammà C: Causes of and prevention strategies for hepatocellular
carcinoma. Semin Oncol. 39:374–383. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Liu L, Zhu XD, Wang WQ, Shen Y, Qin Y, Ren
ZG, Sun HC and Tang ZY: Activation of beta-catenin by hypoxia in
hepatocellular carcinoma contributes to enhanced metastatic
potential and poor prognosis. Clin Cancer Res. 16:2740–2750. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Kinoshita H, Okabe H, Beppu T, Chikamoto
A, Hayashi H, Imai K, Mima K, Nakagawa S, Ishimoto T, Miyake K, et
al: Cystine/glutamic acid transporter is a novel marker for
predicting poorsurvival in patients with hepatocellular carcinoma.
Oncol Rep. 29:685–689. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Kim DH, Kim WD, Kim SK, Moon DH and Lee
SJ: TGF-β1-mediated repression of SLC7A11 drives vulnerability to
GPX4 inhibition in hepatocellular carcinoma cells. Cell Death Dis.
11:4062020. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Wada F, Koga H, Akiba J, Niizeki T,
Iwamoto H, Ikezono Y, Nakamura T, Abe M, Masuda A, Sakaue T, et al:
High expression of CD44v9 and xCT in chemoresistant hepatocellular
carcinoma: Potential targets by sulfasalazine. Cancer Sci.
109:2801–2810. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Bray F, Ferlay J, Soerjomataram I, Siegel
RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN
estimates of incidence and mortality worldwide for 36 cancers in
185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Molina JR, Yang P, Cassivi SD, Schild SE
and Adjei AA: Non-small cell lung cancer: Epidemiology, risk
factors, treatment and survivorship. Mayo Clin Proc. 83:584–594.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Bianco A, Perrotta F, Barra G, Malapelle
U, Rocco D and De Palma R: Prognostic factors and biomarkers of
responses to immune checkpoint inhibitors in lung cancer. Int J Mol
Sci. 20:49312019. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Ji X, Qian J, Rahman SM, Siska PJ, Zou Y,
Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, et al:
xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small
cell lung cancer progression. Oncogene. 37:5007–5019. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Hu K, Li K, Lv J, Feng J, Chen J, Wu H,
Cheng F, Jiang W, Wang J, Pei H, et al: Suppression of the
SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant
lung adenocarcinoma. J Clin Invest. 130:1752–1766. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao
Y and Gu W: Acetylation is crucial for p53-mediated ferroptosis and
tumor suppression. Cell Rep. 17:366–373. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Jennis M, Kung CP, Basu S, Budina-Kolomets
A, Leu JIJ, Khaku S, Scott JP, Cai KQ, Campbell MR, Porter DK, et
al: An African-specific polymorphism in the TP53 gene impairs p53
tumor suppressor function in a mouse model. Genes Dev. 30:918–930.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Okamoto K, Saito Y, Narumi K, Furugen A,
Iseki K and Kobayashi M: Different mechanisms of cisplatin
resistance development in human lung cancer cells. Biochem Biophys
Res Commun. 530:745–750. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Otsubo K, Nosaki K, Imamura CK, Ogata H,
Fujita A, Sakata S, Hirai F, Toyokawa G, Iwama E, Harada T, et al:
Phase I study of salazosulfapyridine in combination with cisplatin
and pemetrexed for advanced non-small-cell lung cancer. Cancer Sci.
108:1843–1849. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Winston JS, Ramanaryanan J and Levine E:
HER-2/neu evaluation in breast cancer: Are we there yet? Am J Clin
Pathol. 121 (Suppl):S33–S49. 2004.PubMed/NCBI
|
|
52
|
Chen MC, Hsu LL, Wang SF, Hsu CY, Lee HC
and Tseng LM: ROS Mediate xCT-dependent cell death in human breast
cancer cells under glucose deprivation. Cells. 9:15982020.
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Yang Y and Yee D: IGF-I regulates redox
status in breast cancer cells by activating the amino acid
transport molecule xC-. Cancer Res. 74:2295–2305. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Ruiu R, Rolih V, Bolli E, Barutello G,
Riccardo F, Quaglino E, Merighi IF, Pericle F, Donofrio G, Cavallo
F and Conti L: Fighting breast cancer stem cells through the
immune-targeting of the xCT cysteine-glutamate antiporter. Cancer
Immunol Immunother. 68:131–141. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Conti L, Bolli E, Di Lorenzo A, Franceschi
V, Macchi F, Riccardo F, Ruiu R, Russo L, Quaglino E, Donofrio G
and Cavallo F: Immunotargeting of the xCT cystine/glutamate
antiporter potentiates the efficacy of HER2-targeted
immunotherapies in breast cancer. Cancer Immunol Res. 8:1039–1053.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Ishiuchi S, Tsuzuki K, Yoshida Y, Yamada
N, Hagimura N, Okado H, Miwa A, Kurihara H, Nakazato Y, Tamura M,
et al: Blockage of Ca(2+)-permeable AMPA receptors suppresses
migration and induces apoptosis in human glioblastoma cells. Nat
Med. 8:971–978. 2002. View
Article : Google Scholar : PubMed/NCBI
|
|
57
|
Robert SM, Buckingham SC, Campbell SL,
Robel S, Holt KT, Ogunrinu-Babarinde T, Warren PP, White DM, Reid
MA, Eschbacher JM, et al: SLC7A11 expression is associated with
seizures and predicts poor survival in patients with malignant
glioma. Sci Transl Med. 7:289ra862015. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Breemen MS, Wilms EB and Vecht CJ:
Epilepsy in patients with brain tumours: Epidemiology, mechanisms,
and management. Lancet Neurol. 6:421–430. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Sørensen MF, Heimisdóttir SB, Sørensen MD,
Mellegaard CS, Wohlleben H, Kristensen BW and Beier CP: High
expression of cysteine-glutamate antiporter xCT (SLC7A11) is an
independent biomarker for epileptic seizures at diagnosis in
glioma. J Neurooncol. 138:49–53. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Polewski MD, Reveron-Thornton RF,
Cherryholmes GA, Marinov GK and Aboody KS: SLC7A11 overexpression
in glioblastoma is associated with increased cancer stem cell-like
properties. Stem Cells Dev. 26:1236–1246. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Tsuchihashi K, Okazaki S, Ohmura M,
Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M,
Seishima R, Iwasaki Y, et al: The EGF receptor promotes the
malignant potential of glioma by regulating amino acid transport
system xc(−). Cancer Res. 76:2954–2963. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Long Y, Tao H, Karachi A, Grippin AJ, Jin
L, Chang YE, Zhang W, Dyson KA, Hou AY, Na M, et al: Dysregulation
of glutamate transport enhances treg function that promotes VEGF
blockade resistance in glioblastoma. Cancer Res. 80:499–509. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Xu X, Zhang X, Wei C, Zheng D, Lu X, Yang
Y, Luo A, Zhang K, Duan X and Wang Y: Targeting SLC7A11
specifically suppresses the progression of colorectal cancer stem
cells via inducing ferroptosis. Eur J Pharm Sci. 152:1054502020.
View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Gout PW, Buckley AR, Simms CR and
Bruchovsky N: Sulfasalazine, a potent suppressor of lymphoma growth
by inhibition of the x(c)-cystine transporter: A new action for an
old drug. Leukemia. 15:1633–1640. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Wang W, Green M, Choi JE, Gijon M, Kennedy
PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, et al: CD8(+) T
cells regulate tumour ferroptosis during cancer immunotherapy.
Nature. 569:270–274. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Ye LF, Chaudhary KR, Zandkarimi F, Harken
AD, Kinslow CJ, Upadhyayula PS, Dovas A, Higgins DM, Tan H, Zhang
Y, et al: Radiation-induced lipid peroxidation triggers ferroptosis
and synergizes with ferroptosis inducers. ACS Chem Biol.
15:469–484. 2020. View Article : Google Scholar : PubMed/NCBI
|
