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Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine

  • Authors:
    • Zheng Han
    • Liu Meng
    • Xiaodong Huang
    • Jie Tan
    • Weijie Liu
    • Wei Chen
    • Yanli Zou
    • Yishan Cai
    • Shasha Huang
    • Aifang Chen
    • Ting Zhan
    • Min Huang
    • Xiaoli Chen
    • Xia Tian
    • Qingxi Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, Hubei 430060, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
    |
    Published online on: December 17, 2021
       https://doi.org/10.3892/ol.2021.13170
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Abstract

A major cause of treatment failure in advanced colon cancer is resistance to chemotherapy. p38 mitogen‑activated protein kinase (MAPK) has been associated with cellular apoptosis and plays an important role in multidrug resistance (MDR) in cancer cells. In the present study the effect of p38 MAPK on the sensitivity of 5‑fluorouracil (5‑FU)‑resistant SW480 (SW480/5‑FU) human colon cancer cells to noscapine was investigated. Following p38 MAPK interference, the inhibitory effect of noscapine on cell viability and proliferation was increased in the SW480/5‑FU cells and there was also a decrease in the expression level of minichromosome maintenance proteins, recombinant Ki‑67 and proliferating cell nuclear antigen. Inhibition of p38 MAPK also enhanced noscapine‑induced G1‑phase cell cycle arrest in the SW480/5‑FU cells and there was also a decrease in the protein and mRNA expression level of cyclin D, cyclin E and cyclin‑dependent kinase 2, and an increase in the expression level of P57. Furthermore, p38 MAPK interference increased noscapine‑induced apoptosis of the SW480/5‑FU cells and there was an increase in the protein and mRNA expression level of caspases‑3 and 8 and Bax, and decreased Bcl‑2 expression level. The sensitivity of the SW480/5‑FU cells to noscapine was also increased following p38 MAPK interference, as demonstrated by MDR inhibition via decreased Akt activity and reduced protein expression level of the MDR proteins P‑glycoprotein, multidrug resistance protein 1 and ATP‑binding cassette G2. These observations indicated that inhibition of p38 MAPK increased the sensitivity of the SW480/5‑FU cells to noscapine by suppressing proliferation, induction of cell cycle arrest and apoptosis, and reversal of MDR in the SW480/5‑FU cells.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Zhang L and Yu J: Role of apoptosis in colon cancer biology, therapy, and prevention. Curr Colorectal Cancer Rep. Oct 1–2013.(Epub ahead of print). doi: 10.1007/s11888-013-0188-z. View Article : Google Scholar

3 

Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RG, Barzi A and Jemal A: Colorectal cancer statistics, 2017. CA Cancer J Clin. 67:177–193. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Imai Y, Ishikawa E, Asada S and Sugimoto Y: Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2. Cancer Res. 65:596–604. 2005.PubMed/NCBI

5 

Mutoh K, Tsukahara S, Mitsuhashi J, Katayama K and Sugimoto Y: Estrogen-mediated post transcriptional down-regulation of P-glycoprotein in MDR1-transduced human breast cancer cells. Cancer Sci. 97:1198–1204. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Xia YZ, Yang L, Xue GM, Zhang C, Guo C, Yang YW, Li SS, Zhang LY, Guo QL and Kong≈ LY: Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma. Oncotarget. 7:56371–56382. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Sasaki K, Tsuno NH, Sunami E, Tsurita G, Kawai K, Nishikawa T, Shuno Y, Hongo K, Hiyoshi M, Kaneko M, et al: Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer. 10:3702010. View Article : Google Scholar : PubMed/NCBI

8 

Tentes IK, Schmidt WM, Krupitza G, Steger GG, Mikulits W, Kortsaris A and Mader RM: Long-term persistence of acquired resistance to 5-fluorouracil in the colon cancer cell line SW620. Exp Cell Res. 316:3172–3181. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Chandra R, Madan J, Singh P, Chandra A, Kumar P, Tomar V and Dass SK: Implications of nanoscale based drug delivery systems in delivery and targeting tubulin binding agent, noscapine in cancer cells. Curr Drug Metab. 13:1476–1483. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Ye K, Ke Y, Keshava N, Shanks J, Kapp JA, Tekmal RR, Petros J and Joshi HC: Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells. Proc Natl Acad Sci USA. 95:1601–1606. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Aneja R, Vangapandu SN, Lopus M, Viswesarappa VG, Dhiman N, Verma A, Chandra R, Panda D and Joshi HC: Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death. Biochem Pharmacol. 72:415–426. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Zhou J, Liu M, Luthra R, Jones J, Aneja R, Chandra R, Tekmal RR and Joshi HC: EM012, a microtubule-interfering agent, inhibits the progression of multidrug-resistant human ovarian cancer both in cultured cells and in athymic nude mice. Cancer Chemother Pharmacol. 55:461–465. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Liu M, Luo XJ, Liao F, Lei XF and Dong WG: Noscapine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo. Cancer Chemother Pharmacol. 67:605–612. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Yang ZR, Liu M, Peng XL, Lei XF, Zhang JX and Dong WG: Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro. Biochem Biophys Res Commun. 421:627–633. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Landen JW, Lang R, McMahon SJ, Rusan NM, Yvon AM, Adams AW, Sorcinelli MD, Campbell R, Bonaccorsi P, Ansel JC, et al: Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma. Cancer Res. 62:4109–4114. 2002.PubMed/NCBI

16 

Ke Y, Ye K, Grossniklaus HE, Archer DR, Joshi HC and Kapp JA: Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses. Cancer Immunol Immunother. 49:217–225. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Ohtsubo K, Yamada T, Zhao L, Jin TF, Takeuchi S, Mouri H, Yamashita K, Yasumoto K, Fujita N, Kitagawa H, et al: Expression of Akt kinase-interacting protein 1, a scaffold protein of the PI3K/PDK1/Akt pathway, in pancreatic cancer. Pancreas. 43:1093–1100. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Xu R, Sato N, Yanai K, Akiyoshi T, Nagai S, Wada J, Koga K, Mibu R, Nakamura M and Katano M: Enhancement of paclitaxel-induced apoptosis by inhibition of mitogen-activated protein kinase pathway in colon cancer cells. Anticancer Res. 29:261–270. 2009.PubMed/NCBI

19 

Kuno Y, Kondo K, Iwata H, Senga T, Akiyama S, Ito K, Takagi H and Hamaguchi M: Tumor-specific activation of mitogen-activated protein kinase in human colorectal and gastric carcinoma tissues. Jpn J Cancer Res. 89:903–909. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Yang SY, Miah A, Sales KM, Fuller B, Seifalian AM and Winslet M: Inhibition of the p38 MAPK pathway sensitises human colon cancer cells to 5-fluorouracil treatment. Int J Oncol. 38:1695–1702. 2011.PubMed/NCBI

21 

Dinicola S, Pasqualato A, Proietti S, Masiello MG, Palombo A, Coluccia P, Canipari R, Catizone A, Ricci G, Harrath H, et al: Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by gamma-secretase inhibition. Life Sci. 145:174–183. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T and Reed JC: IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res. 58:5315–5320. 1998.PubMed/NCBI

24 

Fang JY and Richardson BC: The MAPK signalling pathways and colorectal cancer. Lancet Oncol. 6:322–327. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB and Claret FX: Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J Biol Chem. 278:19245–19256. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Chang L and Karin M: Mammalian MAP kinase signalling cascades. Nature. 410:37–40. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Guo X, Ma N, Wang J, Song J, Bu X, Cheng Y, Sun K, Xiong H, Jiang G, Zhang B, et al: Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. BMC Cancer. 8:3752008. View Article : Google Scholar : PubMed/NCBI

28 

Durai R, Yang SY, Sales KM, Seifalian AM, Goldspink G and Winslet MC: Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. Int J Oncol. 30:883–888. 2007.PubMed/NCBI

29 

Zamzami N, Brenner C, Marzo I, Susin SA and Kroemer G: Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins. Oncogene. 16:2265–2282. 1998. View Article : Google Scholar : PubMed/NCBI

30 

Jeon HK, Choi SU and Jung NP: Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells. Cell Biol Toxicol. 21:115–125. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Tomar V, Kukreti S, Prakash S, Madan J and Chandra R: Noscapine and its analogs as chemotherapeutic agent: Current updates. Curr Top Med Chem. 17:174–188. 2017. View Article : Google Scholar : PubMed/NCBI

32 

DeBono A, Capuano B and Scammells PJ: Progress toward the development of noscapine and derivatives as anticancer agents. J Med Chem. 58:5699–5727. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Chougule MB, Patel AR, Jackson T and Singh M: Antitumor activity of Noscapine in combination with Doxorubicin in triple negative breast cancer. PLoS One. 6:e177332011. View Article : Google Scholar : PubMed/NCBI

34 

Shen W, Liang B, Yin J, Li X and Cheng J: Noscapine Increases the sensitivity of drug-resistant ovarian cancer cell line SKOV3/DDP to cisplatin by regulating cell cycle and activating apoptotic pathways. Cell Biochem Biophys. 72:203–213. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Doddapaneni R, Patel K, Chowdhury N and Singh M: Reversal of drug-resistance by noscapine chemo-sensitization in docetaxel resistant triple negative breast cancer. Sci Rep. 7:158242017. View Article : Google Scholar : PubMed/NCBI

36 

Peck RA, Hewett J, Harding MW, Wang YM, Chaturvedi PR, Bhatnagar A, Ziessman H, Atkins F and Hawkins MJ: Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin. J Clin Oncol. 19:3130–3141. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Cuadrado A and Nebreda AR: Mechanisms and functions of p38 MAPK signalling. Biochem J. 429:403–417. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Katayama K, Yoshioka S, Tsukahara S, Mitsuhashi J and Sugimoto Y: Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein. Mol Cancer Ther. 6:2092–2102. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Zhou XW, Xia YZ, Zhang YL, Luo JG, Han C, Zhang H, Zhang C, Yang L and Kong LY: Tomentodione M sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of p38 MAPK signaling. Oncotarget. 8:101965–101983. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han Z, Meng L, Huang X, Tan J, Liu W, Chen W, Zou Y, Cai Y, Huang S, Chen A, Chen A, et al: Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine. Oncol Lett 23: 52, 2022.
APA
Han, Z., Meng, L., Huang, X., Tan, J., Liu, W., Chen, W. ... Zhu, Q. (2022). Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine. Oncology Letters, 23, 52. https://doi.org/10.3892/ol.2021.13170
MLA
Han, Z., Meng, L., Huang, X., Tan, J., Liu, W., Chen, W., Zou, Y., Cai, Y., Huang, S., Chen, A., Zhan, T., Huang, M., Chen, X., Tian, X., Zhu, Q."Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine". Oncology Letters 23.2 (2022): 52.
Chicago
Han, Z., Meng, L., Huang, X., Tan, J., Liu, W., Chen, W., Zou, Y., Cai, Y., Huang, S., Chen, A., Zhan, T., Huang, M., Chen, X., Tian, X., Zhu, Q."Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine". Oncology Letters 23, no. 2 (2022): 52. https://doi.org/10.3892/ol.2021.13170
Copy and paste a formatted citation
x
Spandidos Publications style
Han Z, Meng L, Huang X, Tan J, Liu W, Chen W, Zou Y, Cai Y, Huang S, Chen A, Chen A, et al: Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine. Oncol Lett 23: 52, 2022.
APA
Han, Z., Meng, L., Huang, X., Tan, J., Liu, W., Chen, W. ... Zhu, Q. (2022). Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine. Oncology Letters, 23, 52. https://doi.org/10.3892/ol.2021.13170
MLA
Han, Z., Meng, L., Huang, X., Tan, J., Liu, W., Chen, W., Zou, Y., Cai, Y., Huang, S., Chen, A., Zhan, T., Huang, M., Chen, X., Tian, X., Zhu, Q."Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine". Oncology Letters 23.2 (2022): 52.
Chicago
Han, Z., Meng, L., Huang, X., Tan, J., Liu, W., Chen, W., Zou, Y., Cai, Y., Huang, S., Chen, A., Zhan, T., Huang, M., Chen, X., Tian, X., Zhu, Q."Inhibition of p38 MAPK increases the sensitivity of 5‑fluorouracil‑resistant SW480 human colon cancer cells to noscapine". Oncology Letters 23, no. 2 (2022): 52. https://doi.org/10.3892/ol.2021.13170
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