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Article

Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma

  • Authors:
    • Natsumi Takamaru
    • Naoyuki Fukuda
    • Kazuya Akita
    • Keiko Kudoh
    • Youji Miyamoto
  • View Affiliations / Copyright

    Affiliations: Department of Oral Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770‑8504, Japan
  • Article Number: 75
    |
    Published online on: January 10, 2022
       https://doi.org/10.3892/ol.2022.13195
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Abstract

Programmed cell death‑1 (PD‑1) and its ligand programmed cell death 1 ligand 1 (PD‑L1) are immune checkpoint inhibitors that play an important role in the host immune avoidance mechanism of tumors. The relationship between PD‑L1 expression and malignancy has been reported in various types of cancer, such as lung and gastric cancer. In addition, epithelial‑mesenchymal transition (EMT) of cancer cells is deeply involved in the invasion and metastasis of cancer. It has been reported that zinc finger E‑box binding homeobox 1 (ZEB‑1), an EMT inducer, contributes to metastasis in pancreatic and colon cancer. The present study aimed to investigate the relationship between the expression patterns of two markers, PD‑L1 and ZEB‑1, and clinicopathological characteristics and prognosis of oral squamous cell carcinoma (OSCC). Biopsy or surgical excision specimens from 169 patients with OSCC were used in the present study. Immunohistochemical staining with monoclonal anti‑PD‑L1 antibody and anti‑ZEB‑1 antibody was conducted. Cases with >1% tumor cells positive for PD‑L1 and those with >10% tumor cells positive for ZEB‑1 were considered positive, respectively. The findings revealed that individual expression of PD‑L1 and ZEB‑1 in OSCC was not associated with tumor size, degree of differentiation or Yamamoto‑Kohama invasion pattern classification. However, co‑expression of PD‑L1 and ZEB‑1 was associated with higher cervical lymph node metastasis and a lower survival rate. In conclusion, the results of the present study indicated that co‑expression of PD‑L1 and ZEB‑1 could serve as a potential marker for the prognosis of patients with OSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Takamaru N, Fukuda N, Akita K, Kudoh K and Miyamoto Y: Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma. Oncol Lett 23: 75, 2022.
APA
Takamaru, N., Fukuda, N., Akita, K., Kudoh, K., & Miyamoto, Y. (2022). Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma. Oncology Letters, 23, 75. https://doi.org/10.3892/ol.2022.13195
MLA
Takamaru, N., Fukuda, N., Akita, K., Kudoh, K., Miyamoto, Y."Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma". Oncology Letters 23.3 (2022): 75.
Chicago
Takamaru, N., Fukuda, N., Akita, K., Kudoh, K., Miyamoto, Y."Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma". Oncology Letters 23, no. 3 (2022): 75. https://doi.org/10.3892/ol.2022.13195
Copy and paste a formatted citation
x
Spandidos Publications style
Takamaru N, Fukuda N, Akita K, Kudoh K and Miyamoto Y: Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma. Oncol Lett 23: 75, 2022.
APA
Takamaru, N., Fukuda, N., Akita, K., Kudoh, K., & Miyamoto, Y. (2022). Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma. Oncology Letters, 23, 75. https://doi.org/10.3892/ol.2022.13195
MLA
Takamaru, N., Fukuda, N., Akita, K., Kudoh, K., Miyamoto, Y."Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma". Oncology Letters 23.3 (2022): 75.
Chicago
Takamaru, N., Fukuda, N., Akita, K., Kudoh, K., Miyamoto, Y."Association of PD‑L1 and ZEB‑1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma". Oncology Letters 23, no. 3 (2022): 75. https://doi.org/10.3892/ol.2022.13195
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