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Article Open Access

LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression

Retraction in: /10.3892/ol.2024.14747
  • Authors:
    • Tao Jiang
    • Zhong-Bing Luo
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 100
    |
    Published online on: January 27, 2022
       https://doi.org/10.3892/ol.2022.13220
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Abstract

Breast cancer (BC) is a malignant disease and the most commonly diagnosed cancer in women. Numerous studies have previously verified the important role of long non‑coding RNAs in a number of biological processes in BC. In the present study, analysis of The Cancer Genome Atlas database and reverse transcription‑quantitative PCR demonstrated that LOC102724163 expression levels were significantly upregulated in BC tissues compared to matched adjacent normal tissues and were associated with an unfavorable prognosis in patients with BC. Gain or loss of function assays indicated that overexpression of LOC102724163 significantly increased tumorgenicity in vivo and cell migration, proliferation and invasion in vitro. In the mechanistical aspect, LOC102724163 sponged microRNA (miR)‑508‑5p to elevate MUC19 expression. Additionally, rescue assays ascertained the function of the LOC102724163/miR‑508‑5p/MUC19 axis in the proliferation and invasion of BC cells. To the best of our knowledge, this is the first study to have demonstrated that LOC102724163 may act as a competing endogenous RNA to control MUC19 expression levels by competitively sponging miR‑508‑5p to modulate BC progression. Therefore, the present study has provided new insights into BC diagnosis and treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang T and Luo Z: LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression Retraction in /10.3892/ol.2024.14747. Oncol Lett 23: 100, 2022.
APA
Jiang, T., & Luo, Z. (2022). LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression Retraction in /10.3892/ol.2024.14747. Oncology Letters, 23, 100. https://doi.org/10.3892/ol.2022.13220
MLA
Jiang, T., Luo, Z."LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression Retraction in /10.3892/ol.2024.14747". Oncology Letters 23.3 (2022): 100.
Chicago
Jiang, T., Luo, Z."LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression Retraction in /10.3892/ol.2024.14747". Oncology Letters 23, no. 3 (2022): 100. https://doi.org/10.3892/ol.2022.13220
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang T and Luo Z: LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression Retraction in /10.3892/ol.2024.14747. Oncol Lett 23: 100, 2022.
APA
Jiang, T., & Luo, Z. (2022). LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression Retraction in /10.3892/ol.2024.14747. Oncology Letters, 23, 100. https://doi.org/10.3892/ol.2022.13220
MLA
Jiang, T., Luo, Z."LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression Retraction in /10.3892/ol.2024.14747". Oncology Letters 23.3 (2022): 100.
Chicago
Jiang, T., Luo, Z."LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression Retraction in /10.3892/ol.2024.14747". Oncology Letters 23, no. 3 (2022): 100. https://doi.org/10.3892/ol.2022.13220
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