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Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma

  • Authors:
    • Stephen Ahn
    • Young Il Kim
    • Ja Young Shin
    • Jae-Sung Park
    • Changyoung Yoo
    • Youn Soo Lee
    • Yong-Kil Hong
    • Sin-Soo Jeun
    • Seung Ho Yang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea, Department of Neurosurgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea, Department of Hospital Pathology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea, Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
    Copyright: © Ahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 114
    |
    Published online on: February 9, 2022
       https://doi.org/10.3892/ol.2022.13234
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Abstract

Procarbazine, lomustine and vincristine (PCV) chemotherapy is considered a salvage option for adult glioma; however, its significant toxicities frequently lead to dose reduction or discontinuation in patients with recurrent glioma. The current study evaluated the safety and efficacy of modified procarbazine and lomustine (PC) chemotherapy that omits vincristine and reduces the lomustine dose compared with those of conventional PCV chemotherapy. Using electronic medical records, all patients with adult recurrent glioma who received PC or PCV chemotherapy between 2009 and 2020 at Seoul St. Mary's Hospital or St. Vincent's Hospital were examined retrospectively. A total of 59 patients met the eligibility criteria. Among them, 15 patients received modified PC chemotherapy (PC group) and 44 patients received PCV chemotherapy (PCV group). The PC group presented a significantly lower hematology toxicity (anemia, 6.7 vs. 45.5%, P=0.02; thrombocytopenia 20.0 vs. 70.4%, P<0.001). Additionally, the clinical impacts of PC chemotherapy, including delay of a cycle, dose reduction, discontinuation of drug(s) or total cessation of chemotherapy, were significantly less frequent compared with the PCV group (26.7 vs. 68.2%, P=0.012). The overall survival of the PC group was also significantly longer than that of PCV group (396 vs. 232 days, P=0.042), while there was no significant difference in progression‑free survival between the two groups (284.5 vs. 131 days, P=0.077). The results suggested that modified PC chemotherapy may be an alternative chemotherapeutic regimen with tolerable toxicity and without loss of clinical efficacy in patients with recurrent adult glioma. Further prospective and larger studies are required to validate our findings.
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Copy and paste a formatted citation
Spandidos Publications style
Ahn S, Kim YI, Shin JY, Park J, Yoo C, Lee YS, Hong Y, Jeun S and Yang SH: Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma. Oncol Lett 23: 114, 2022.
APA
Ahn, S., Kim, Y.I., Shin, J.Y., Park, J., Yoo, C., Lee, Y.S. ... Yang, S.H. (2022). Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma. Oncology Letters, 23, 114. https://doi.org/10.3892/ol.2022.13234
MLA
Ahn, S., Kim, Y. I., Shin, J. Y., Park, J., Yoo, C., Lee, Y. S., Hong, Y., Jeun, S., Yang, S. H."Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma". Oncology Letters 23.4 (2022): 114.
Chicago
Ahn, S., Kim, Y. I., Shin, J. Y., Park, J., Yoo, C., Lee, Y. S., Hong, Y., Jeun, S., Yang, S. H."Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma". Oncology Letters 23, no. 4 (2022): 114. https://doi.org/10.3892/ol.2022.13234
Copy and paste a formatted citation
x
Spandidos Publications style
Ahn S, Kim YI, Shin JY, Park J, Yoo C, Lee YS, Hong Y, Jeun S and Yang SH: Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma. Oncol Lett 23: 114, 2022.
APA
Ahn, S., Kim, Y.I., Shin, J.Y., Park, J., Yoo, C., Lee, Y.S. ... Yang, S.H. (2022). Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma. Oncology Letters, 23, 114. https://doi.org/10.3892/ol.2022.13234
MLA
Ahn, S., Kim, Y. I., Shin, J. Y., Park, J., Yoo, C., Lee, Y. S., Hong, Y., Jeun, S., Yang, S. H."Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma". Oncology Letters 23.4 (2022): 114.
Chicago
Ahn, S., Kim, Y. I., Shin, J. Y., Park, J., Yoo, C., Lee, Y. S., Hong, Y., Jeun, S., Yang, S. H."Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma". Oncology Letters 23, no. 4 (2022): 114. https://doi.org/10.3892/ol.2022.13234
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