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ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma

  • Authors:
    • Niu Niu
    • Jialong Zeng
    • Xianni Ke
    • Wenyu Zheng
    • Chunmei Fu
    • Shiqi Lv
    • Jianghong Fu
    • Yang Yu
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, P.R. China, Department of Internal Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, P.R. China
    Copyright: © Niu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 131
    |
    Published online on: February 23, 2022
       https://doi.org/10.3892/ol.2022.13251
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Abstract

5‑Aminoimidazole‑4‑carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), a catalysing enzyme in the de novo purine biosynthetic pathway, has been previously reported to be upregulated and to participate in myeloma and hepatocellular carcinoma progression. In the present study, by using bioinformatics technology, a higher ATIC expression was identified in lung adenocarcinoma (LUAD) tissues than in normal tissues, and ATIC expression was found to be positively associated with Myc expression in LUAD tissues. In addition, the role of ATIC in modulating the growth and migration of LUAD cells was explored and the involvement of Myc was revealed. ATIC expression in 56 paired LUAD and tumour adjacent non‑cancerous tissues was assessed using reverse transcription‑quantitative PCR and western blot analysis. Pearson's correlation analysis was applied to evaluate the correlation between ATIC and Myc expression levels in LUAD tissues. A rescue experiment was performed to explore the role of ATIC/Myc in regulating the growth, migration and invasion of HCC827 and NCI‑H1435 cells. It was demonstrated that ATIC was overexpressed in LUAD tissues, particularly in advanced‑stage LUAD, and was predicted to be associated with an advanced TNM stage, a higher lymph node metastasis rate, poor tissue differentiation and a lower overall survival rate. ATIC overexpression promoted cell growth, migratory and invasive capacities, whereas this effect was abrogated by Myc knockdown in the HCC827 and NCI‑H1435 cells. On the whole, the present study demonstrates that ATIC promotes LUAD cell growth and migration by increasing Myc expression.
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Copy and paste a formatted citation
Spandidos Publications style
Niu N, Zeng J, Ke X, Zheng W, Fu C, Lv S, Fu J and Yu Y: ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma. Oncol Lett 23: 131, 2022.
APA
Niu, N., Zeng, J., Ke, X., Zheng, W., Fu, C., Lv, S. ... Yu, Y. (2022). ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma. Oncology Letters, 23, 131. https://doi.org/10.3892/ol.2022.13251
MLA
Niu, N., Zeng, J., Ke, X., Zheng, W., Fu, C., Lv, S., Fu, J., Yu, Y."ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma". Oncology Letters 23.4 (2022): 131.
Chicago
Niu, N., Zeng, J., Ke, X., Zheng, W., Fu, C., Lv, S., Fu, J., Yu, Y."ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma". Oncology Letters 23, no. 4 (2022): 131. https://doi.org/10.3892/ol.2022.13251
Copy and paste a formatted citation
x
Spandidos Publications style
Niu N, Zeng J, Ke X, Zheng W, Fu C, Lv S, Fu J and Yu Y: ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma. Oncol Lett 23: 131, 2022.
APA
Niu, N., Zeng, J., Ke, X., Zheng, W., Fu, C., Lv, S. ... Yu, Y. (2022). ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma. Oncology Letters, 23, 131. https://doi.org/10.3892/ol.2022.13251
MLA
Niu, N., Zeng, J., Ke, X., Zheng, W., Fu, C., Lv, S., Fu, J., Yu, Y."ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma". Oncology Letters 23.4 (2022): 131.
Chicago
Niu, N., Zeng, J., Ke, X., Zheng, W., Fu, C., Lv, S., Fu, J., Yu, Y."ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma". Oncology Letters 23, no. 4 (2022): 131. https://doi.org/10.3892/ol.2022.13251
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