Open Access

PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials

  • Authors:
    • Maria Saveria Rotundo
    • Vincenzo Bagnardi
    • Miryam Rotundo
    • Mario Comandè
    • Maria Giulia Zampino
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  • Published online on: February 23, 2022     https://doi.org/10.3892/ol.2022.13254
  • Article Number: 134
  • Copyright: © Rotundo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Currently, standard treatment of patients with metastatic colorectal cancer (mCRC) comprises chemotherapy (CT) and/or biological therapy (BT) and/or best supportive care (BSC). The present study performed a meta‑analysis on five phase II‑III randomized clinical trials, which compared CT/BT/BSC as the control arm with the immune checkpoint inhibitors (ICIs) anti‑programmed cell death protein 1 (PD‑1) or its ligand (PD‑L1) alone or in combination with cytotoxic T lymphocyte antigen 4 or mitogen activated protein kinase kinase inhibitors as the experimental arm, to evaluate whether a standard approach could be overcome using the novel target therapy strategy. Pooled hazard ratio (HR) for progression‑free survival was 0.95 in favor of the experimental arm [95% confidence interval (CI), 0.74‑1.22; P=0.68]. Heterogeneity was significant: Cochran's Q, 21.0; P=0.0082; I2 index, 76%. Pooled HR for overall survival was 0.88 in favor of the experimental arm (95% CI, 0.75‑1.02; P=0.08). Heterogeneity was not significant (Cochran's Q, 6.0; P=0.31; I2 index, 16%). The present meta‑analysis demonstrated a trend toward the improvement of survival by PD‑1/PD‑L1 blockade in mCRC. Further homogeneous studies are necessary to strengthen these results, beyond the known benefits of ICIs in deficient mismatch repair/high microsatellite instability tumors.
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April-2022
Volume 23 Issue 4

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Spandidos Publications style
Rotundo MS, Bagnardi V, Rotundo M, Comandè M and Zampino MG: PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials. Oncol Lett 23: 134, 2022
APA
Rotundo, M.S., Bagnardi, V., Rotundo, M., Comandè, M., & Zampino, M.G. (2022). PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials. Oncology Letters, 23, 134. https://doi.org/10.3892/ol.2022.13254
MLA
Rotundo, M. S., Bagnardi, V., Rotundo, M., Comandè, M., Zampino, M. G."PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials". Oncology Letters 23.4 (2022): 134.
Chicago
Rotundo, M. S., Bagnardi, V., Rotundo, M., Comandè, M., Zampino, M. G."PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials". Oncology Letters 23, no. 4 (2022): 134. https://doi.org/10.3892/ol.2022.13254