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PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials

  • Authors:
    • Maria Saveria Rotundo
    • Vincenzo Bagnardi
    • Miryam Rotundo
    • Mario Comandè
    • Maria Giulia Zampino
  • View Affiliations / Copyright

    Affiliations: Complex Operative Unit of Medical Oncology, Uboldo Hospital, Cernusco Sul Naviglio, I‑20063 Milan, Italy, Department of Statistics and Quantitative Methods, University of Milan‑Bicocca, I‑20126 Milan, Italy, Department of Experimental and Clinical Medicine‑Medical, Veterinary and Pharmaceutical Biotechnologies, Magna Graecia University of Catanzaro, I‑88100 Catanzaro, Italy, Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico, I‑20141 Milan, Italy
    Copyright: © Rotundo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 134
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    Published online on: February 23, 2022
       https://doi.org/10.3892/ol.2022.13254
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Abstract

Currently, standard treatment of patients with metastatic colorectal cancer (mCRC) comprises chemotherapy (CT) and/or biological therapy (BT) and/or best supportive care (BSC). The present study performed a meta‑analysis on five phase II‑III randomized clinical trials, which compared CT/BT/BSC as the control arm with the immune checkpoint inhibitors (ICIs) anti‑programmed cell death protein 1 (PD‑1) or its ligand (PD‑L1) alone or in combination with cytotoxic T lymphocyte antigen 4 or mitogen activated protein kinase kinase inhibitors as the experimental arm, to evaluate whether a standard approach could be overcome using the novel target therapy strategy. Pooled hazard ratio (HR) for progression‑free survival was 0.95 in favor of the experimental arm [95% confidence interval (CI), 0.74‑1.22; P=0.68]. Heterogeneity was significant: Cochran's Q, 21.0; P=0.0082; I2 index, 76%. Pooled HR for overall survival was 0.88 in favor of the experimental arm (95% CI, 0.75‑1.02; P=0.08). Heterogeneity was not significant (Cochran's Q, 6.0; P=0.31; I2 index, 16%). The present meta‑analysis demonstrated a trend toward the improvement of survival by PD‑1/PD‑L1 blockade in mCRC. Further homogeneous studies are necessary to strengthen these results, beyond the known benefits of ICIs in deficient mismatch repair/high microsatellite instability tumors.
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Copy and paste a formatted citation
Spandidos Publications style
Rotundo MS, Bagnardi V, Rotundo M, Comandè M and Zampino MG: PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials. Oncol Lett 23: 134, 2022.
APA
Rotundo, M.S., Bagnardi, V., Rotundo, M., Comandè, M., & Zampino, M.G. (2022). PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials. Oncology Letters, 23, 134. https://doi.org/10.3892/ol.2022.13254
MLA
Rotundo, M. S., Bagnardi, V., Rotundo, M., Comandè, M., Zampino, M. G."PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials". Oncology Letters 23.4 (2022): 134.
Chicago
Rotundo, M. S., Bagnardi, V., Rotundo, M., Comandè, M., Zampino, M. G."PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials". Oncology Letters 23, no. 4 (2022): 134. https://doi.org/10.3892/ol.2022.13254
Copy and paste a formatted citation
x
Spandidos Publications style
Rotundo MS, Bagnardi V, Rotundo M, Comandè M and Zampino MG: PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials. Oncol Lett 23: 134, 2022.
APA
Rotundo, M.S., Bagnardi, V., Rotundo, M., Comandè, M., & Zampino, M.G. (2022). PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials. Oncology Letters, 23, 134. https://doi.org/10.3892/ol.2022.13254
MLA
Rotundo, M. S., Bagnardi, V., Rotundo, M., Comandè, M., Zampino, M. G."PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials". Oncology Letters 23.4 (2022): 134.
Chicago
Rotundo, M. S., Bagnardi, V., Rotundo, M., Comandè, M., Zampino, M. G."PD‑1/PD‑L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta‑analysis of randomized trials". Oncology Letters 23, no. 4 (2022): 134. https://doi.org/10.3892/ol.2022.13254
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