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Review Open Access

Management of chemotherapy dose intensity for metastatic colorectal cancer (Review)

  • Authors:
    • Xuelei Chu
    • Peng Xue
    • Shijie Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Wangjing Hospital Affiliated to China Academy of Chinese Medical Sciences, Beijing 100102, P.R. China
    Copyright: © Chu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 141
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    Published online on: March 11, 2022
       https://doi.org/10.3892/ol.2022.13261
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Abstract

Chemotherapy dose intensity is a momentous parameter of antitumor clinical medication. In certain clinical trials, the actual application dose of the chemotherapeutic drugs is frequently different from the prescribed dose. The chemotherapy dose intensity completed in different trials is also variable, which has an impact on the treatment efficacy, disease prognosis and patient safety. When these agents are tested in the population, chemotherapy reduction and delay or failure to complete the planned cycle constantly occur due to age, performance status, adverse reactions and other reasons, resulting in the modification of the chemotherapy dose intensity. The present review analyzed the correlation between the chemotherapy dose intensity and the incidence of adverse reactions, the treatment efficacy and disease prognosis in clinical trials of metastatic colorectal cancer. Moreover, the clinical applications of chemotherapy dose intensity were discussed. Based on individual differences, the present review analyzed the clinical trials that examined the efficacy of the chemotherapy dose intensity in different patient populations. The conclusions suggested that different populations require a specific dose intensity to reduce treatment toxicity without affecting the curative effect.
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Copy and paste a formatted citation
Spandidos Publications style
Chu X, Xue P and Zhu S: Management of chemotherapy dose intensity for metastatic colorectal cancer (Review). Oncol Lett 23: 141, 2022.
APA
Chu, X., Xue, P., & Zhu, S. (2022). Management of chemotherapy dose intensity for metastatic colorectal cancer (Review). Oncology Letters, 23, 141. https://doi.org/10.3892/ol.2022.13261
MLA
Chu, X., Xue, P., Zhu, S."Management of chemotherapy dose intensity for metastatic colorectal cancer (Review)". Oncology Letters 23.5 (2022): 141.
Chicago
Chu, X., Xue, P., Zhu, S."Management of chemotherapy dose intensity for metastatic colorectal cancer (Review)". Oncology Letters 23, no. 5 (2022): 141. https://doi.org/10.3892/ol.2022.13261
Copy and paste a formatted citation
x
Spandidos Publications style
Chu X, Xue P and Zhu S: Management of chemotherapy dose intensity for metastatic colorectal cancer (Review). Oncol Lett 23: 141, 2022.
APA
Chu, X., Xue, P., & Zhu, S. (2022). Management of chemotherapy dose intensity for metastatic colorectal cancer (Review). Oncology Letters, 23, 141. https://doi.org/10.3892/ol.2022.13261
MLA
Chu, X., Xue, P., Zhu, S."Management of chemotherapy dose intensity for metastatic colorectal cancer (Review)". Oncology Letters 23.5 (2022): 141.
Chicago
Chu, X., Xue, P., Zhu, S."Management of chemotherapy dose intensity for metastatic colorectal cancer (Review)". Oncology Letters 23, no. 5 (2022): 141. https://doi.org/10.3892/ol.2022.13261
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