Open Access

Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study

  • Authors:
    • Chiaki Imai
    • Hiromi Saeki
    • Kohei Yamamoto
    • Ayano Ichikawa
    • Makoto Arai
    • Akinobu Tawada
    • Takaaki Suzuki
    • Yuichi Takiguchi
    • Toyoyuki Hanazawa
    • Itsuko Ishii
  • View Affiliations

  • Published online on: March 15, 2022     https://doi.org/10.3892/ol.2022.13271
  • Article Number: 152
  • Copyright: © Imai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Clinical trials have not fully demonstrated the efficacy and safety of radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer (LA‑SCCHN) in patients with cisplatin‑ineligible renal dysfunction. Patients who received radiotherapy plus cetuximab for LA‑SCCHN at Chiba University Hospital (Chiba, Japan) between July 2013 and October 2018 were retrospectively reviewed. Background characteristics and locoregional control and overall survival rates were compared between patients with and without renal dysfunction. Survival was examined using Kaplan‑Meier analysis and an adjusted Cox proportional hazards model. Kaplan‑Meier analysis demonstrated that overall survival was shorter in patients with creatinine clearance of <45 ml/min (P=0.041; log‑rank test). However, there was no difference in the locoregional control rate (P=0.477; log‑rank test). Adjusted Cox analysis revealed that the risk of death was increased by 2.52‑fold (hazard ratio, 2.52; 95% confidence interval, 1.01‑6.30; P=0.048) if creatinine clearance was <45 ml/min. Moderate to severe renal dysfunction did not affect the locoregional control rate in patients with LA‑SCCHN treated with radiotherapy plus cetuximab but was an adverse prognostic factor.
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May-2022
Volume 23 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Imai C, Saeki H, Yamamoto K, Ichikawa A, Arai M, Tawada A, Suzuki T, Takiguchi Y, Hanazawa T, Ishii I, Ishii I, et al: Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study. Oncol Lett 23: 152, 2022
APA
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A. ... Ishii, I. (2022). Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study. Oncology Letters, 23, 152. https://doi.org/10.3892/ol.2022.13271
MLA
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A., Suzuki, T., Takiguchi, Y., Hanazawa, T., Ishii, I."Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study". Oncology Letters 23.5 (2022): 152.
Chicago
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A., Suzuki, T., Takiguchi, Y., Hanazawa, T., Ishii, I."Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study". Oncology Letters 23, no. 5 (2022): 152. https://doi.org/10.3892/ol.2022.13271