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Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study

  • Authors:
    • Chiaki Imai
    • Hiromi Saeki
    • Kohei Yamamoto
    • Ayano Ichikawa
    • Makoto Arai
    • Akinobu Tawada
    • Takaaki Suzuki
    • Yuichi Takiguchi
    • Toyoyuki Hanazawa
    • Itsuko Ishii
  • View Affiliations / Copyright

    Affiliations: Division of Pharmacy, Chiba University Hospital, Chiba, Chiba 260‑8677, Japan, Department of Gastroenterology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo, Chiba 276‑8524, Japan, Department of Nursing, Faculty of Health Care Sciences, Chiba Prefectural University of Health Sciences, Chiba, Chiba 261‑0014, Japan, Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba, Chiba 260‑8670, Japan, Department of Otorhinolaryngology/Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba 260‑8670, Japan
    Copyright: © Imai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 152
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    Published online on: March 15, 2022
       https://doi.org/10.3892/ol.2022.13271
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Abstract

Clinical trials have not fully demonstrated the efficacy and safety of radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer (LA‑SCCHN) in patients with cisplatin‑ineligible renal dysfunction. Patients who received radiotherapy plus cetuximab for LA‑SCCHN at Chiba University Hospital (Chiba, Japan) between July 2013 and October 2018 were retrospectively reviewed. Background characteristics and locoregional control and overall survival rates were compared between patients with and without renal dysfunction. Survival was examined using Kaplan‑Meier analysis and an adjusted Cox proportional hazards model. Kaplan‑Meier analysis demonstrated that overall survival was shorter in patients with creatinine clearance of <45 ml/min (P=0.041; log‑rank test). However, there was no difference in the locoregional control rate (P=0.477; log‑rank test). Adjusted Cox analysis revealed that the risk of death was increased by 2.52‑fold (hazard ratio, 2.52; 95% confidence interval, 1.01‑6.30; P=0.048) if creatinine clearance was <45 ml/min. Moderate to severe renal dysfunction did not affect the locoregional control rate in patients with LA‑SCCHN treated with radiotherapy plus cetuximab but was an adverse prognostic factor.
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1 

Brizel DM, Albers ME, Fisher SR, Scher RL, Richtsmeier WJ, Hars V, George SL, Huang AT and Prosnitz LR: Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med. 338:1798–1804. 1998. View Article : Google Scholar : PubMed/NCBI

2 

Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, et al: Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 349:2091–2098. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Adelstein DJ, Li Y, Adams GL, Wagner H Jr, Kish JA, Ensley JF, Schuller DE and Forastiere AA: An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol. 21:92–98. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J and Calais G: Final results of the 94–01 French head and neck oncology and radiotherapy group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol. 22:69–76. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Corvo R: Evidence-based radiation oncology in head and neck squamous cell carcinoma. Radiother Oncol. 85:156–170. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Bernier J and Schneider D: Cetuximab combined with radiotherapy: An alternative to chemoradiotherapy for patients with locally advanced squamous cell carcinomas of the head and neck? Eur J Cancer. 43:35–45. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Spreafico A, Huang SH, Xu W, Granata R, Liu CS, Waldron JN, Chen E, Ringash J, Bayley A, Chan KK, et al: Impact of cisplatin dose intensity on human papillomavirus-related and -unrelated locally advanced head and neck squamous cell carcinoma. Eur J Cancer. 67:174–182. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Szturz P, Wouters K, Kiyota N, Tahara M, Prabhash K, Noronha V, Adelstein D, Van Gestel D and Vermorken JB: Low-Dose vs. High-dose cisplatin: Lessons learned from 59 chemoradiotherapy trials in head and neck cancer. Front Oncol. 9:862019. View Article : Google Scholar : PubMed/NCBI

9 

Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, et al: Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 354:567–578. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Curran D, Giralt J, Harari PM, Ang KK, Cohen RB, Kies MS, Jassem J, Baselga J, Rowinsky EK, Amellal N, et al: Quality of life in head and neck cancer patients after treatment with high-dose radiotherapy alone or in combination with cetuximab. J Clin Oncol. 25:2191–2197. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, et al: Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 11:21–28. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Liu L: Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins. Protein Cell. 9:15–32. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Dirks NL, Nolting A, Kovar A and Meibohm B: Population pharmacokinetics of cetuximab in patients with squamous cell carcinoma of the head and neck. J Clin Pharmacol. 48:267–278. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Aldoss IT, Plumb T, Zhen WK, Lydiatt DD and Ganti AK: Cetuximab in hemodialysis: A case report. Head Neck. 31:1647–1650. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Krens LL, Baas JM, Verboom MC, Paintaud G, Desvignes C, Guchelaar HJ and Gelderblom H: Pharmacokinetics and safety of cetuximab in a patient with renal dysfunction. Cancer Chemother Pharmacol. 73:1303–1306. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, et al: Long-term results of RTOG 91–11: A comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. 31:845–852. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Bourhis J, Sire C, Graff P, Grégoire V, Maingon P, Calais G, Gery B, Martin L, Alfonsi M, Desprez P, et al: Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99–02): An open-label phase 3 randomised trial. Lancet Oncol. 13:145–153. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Huang SM and Harari PM: Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res. 6:2166–2174. 2000.PubMed/NCBI

19 

Milas L, Mason K, Hunter N, Petersen S, Yamakawa M, Ang K, Mendelsohn J and Fan Z: In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res. 6:701–708. 2000.PubMed/NCBI

20 

Harari PM and Huang SM: Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation. Int J Radiat Oncol Biol Phys. 49:427–433. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Koutcher L, Sherman E, Fury M, Wolden S, Zhang Z, Mo Q, Stewart L, Schupak K, Gelblum D, Wong R, et al: Concurrent cisplatin and radiation versus cetuximab and radiation for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 81:915–922. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Magrini SM, Buglione M, Corvo R, Pirtoli L, Paiar F, Ponticelli P, Petrucci A, Bacigalupo A, Crociani M, Lastrucci L, et al: Cetuximab and radiotherapy versus cisplatin and radiotherapy for locally advanced head and neck cancer: A randomized phase II trial. J Clin Oncol. 34:427–435. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Bauml JM, Vinnakota R, Anna Park YH, Bates SE, Fojo T, Aggarwal C, Di Stefano J, Knepley C, Limaye S, Mamtani R, et al: Cisplatin versus cetuximab with definitive concurrent radiotherapy for head and neck squamous cell carcinoma: An analysis of Veterans Health Affairs data. Cancer. 125:406–415. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Gillison ML, Trotti AM, Harris J, Eisbruch A, Harari PM, Adelstein DJ, Jordan RCK, Zhao W, Sturgis EM, Burtness B, et al: Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): A randomised, multicentre, non-inferiority trial. Lancet. 393:40–50. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O'Toole L, et al: Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): An open-label randomised controlled phase 3 trial. Lancet. 393:51–60. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Petrelli F, Coinu A, Riboldi V, Borgonovo K, Ghilardi M, Cabiddu M, Lonati V, Sarti E and Barni S: Concomitant platinum-based chemotherapy or cetuximab with radiotherapy for locally advanced head and neck cancer: A systematic review and meta-analysis of published studies. Oral Oncol. 50:1041–1048. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Tang C, Chan C, Jiang W, Murphy JD, von Eyben R, Colevas AD, Pinto H, Lee-Enriquez N, Kong C and Le QT: Concurrent cetuximab versus platinum-based chemoradiation for the definitive treatment of locoregionally advanced head and neck cancer. Head Neck. 37:386–392. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Riaz N, Sherman E, Koutcher L, Shapiro L, Katabi N, Zhang Z, Shi W, Fury M, Wong R, Wolden S, et al: Concurrent chemoradiotherapy with cisplatin versus cetuximab for squamous cell carcinoma of the head and neck. Am J Clin Oncol. 39:27–31. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Xiang M, Holsinger FC, Colevas AD, Chen MM, Le QT and Beadle BM: Survival of patients with head and neck cancer treated with definitive radiotherapy and concurrent cisplatin or concurrent cetuximab: A Surveillance, Epidemiology, and End Results-Medicare analysis. Cancer. 124:4486–4494. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Frampton JE: Spotlight on cetuximab in squamous cell carcinoma of the head and necky. BioDrugs. 25:129–133. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Villavicencio M, Granados-García M, Vilajosana E and Domínguez-Cherit J: Management of radiodermatitis associated with cetuximab in squamous cell carcinomas of the head and neck. Int J Dermatol. 56:602–609. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Lugtenberg RT, Boers-Doets CB, Witteveen PO, van Herpen CML, Wymenga ANM, de Groot JWB, Hoeben A, Del Grande C, van Doorn B, Koldenhof JJ, et al: Prospective practice survey of management of cetuximab-related skin reactions. Support Care Cancer. 29:3497–3506. 2021. View Article : Google Scholar : PubMed/NCBI

33 

Bonomo P, Loi M, Desideri I, Olmetto E, Delli Paoli C, Terziani F, Greto D, Mangoni M, Scoccianti S, Simontacchi G, et al: Incidence of skin toxicity in squamous cell carcinoma of the head and neck treated with radiotherapy and cetuximab: A systematic review. Crit Rev Oncol Hematol. 120:98–110. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Mayfield JD, Mercado CE, Kaye FJ and Mendenhall WM: Cetuximab-associated pulmonary toxicity in concurrent chemoradiation for the treatment of a squamous cell carcinoma of the head and neck. Head Neck. 41:E55–E58. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Machiels JP, Rene Leemans C, Golusinski W, Grau C, Licitra L and Gregoire V; EHNS Executive Board. Electronic address, : simplesecretariat@ehns.org; ESMO Guidelines Committee. Electronic address: simpleclinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: simpleinfo@estro.org: Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 31:1462–1475. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Charlson ME, Pompei P, Ales KL and MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis. 40:373–383. 1987. View Article : Google Scholar : PubMed/NCBI

37 

Kintzel PE and Dorr RT: Anticancer drug renal toxicity and elimination: Dosing guidelines for altered renal function. Cancer Treat Rev. 21:33–64. 1995. View Article : Google Scholar : PubMed/NCBI

38 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Torres da Costa E Silva V, Costalonga EC, Coelho FO, Caires RA and Burdmann EA: Assessment of kidney function in patients with cancer. Adv Chronic Kidney Dis. 25:49–56. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Ragin CC and Taioli E: Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta-analysis. Int J Cancer. 121:1813–1820. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, Westra WH, Chung CH, Jordan RC, Lu C, et al: Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 363:24–35. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Pignon JP, le Maitre A, Maillard E and Bourhis J; MACH-NC Collaborative Group, : Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiother Oncol. 92:4–14. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Sanabria A, Carvalho AL, Vartanian JG, Magrin J, Ikeda MK and Kowalski LP: Comorbidity is a prognostic factor in elderly patients with head and neck cancer. Ann Surg Oncol. 14:1449–1457. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Homma A, Hayashi R, Kawabata K, Fujii T, Iwae S, Hasegawa Y, Nibu K, Kato T, Shiga K, Matsuura K, et al: Association of impaired renal function and poor prognosis in oropharyngeal squamous cell carcinoma. Head Neck. 38:1495–1500. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Kiyota N, Tahara M, Fujii H, Yamazaki T, Mitani H, Iwae S, Fujimoto Y, Onozawa Y, Hanai N, Ogawa T, et al: Phase II/III trial of post-operative chemoradiotherapy comparing 3-weekly cisplatin with weekly cisplatin in high-risk patients with squamous cell carcinoma of head and neck (JCOG1008). J Clin Oncol. 38 (15_suppl):S65022020. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Imai C, Saeki H, Yamamoto K, Ichikawa A, Arai M, Tawada A, Suzuki T, Takiguchi Y, Hanazawa T, Ishii I, Ishii I, et al: Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study. Oncol Lett 23: 152, 2022.
APA
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A. ... Ishii, I. (2022). Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study. Oncology Letters, 23, 152. https://doi.org/10.3892/ol.2022.13271
MLA
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A., Suzuki, T., Takiguchi, Y., Hanazawa, T., Ishii, I."Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study". Oncology Letters 23.5 (2022): 152.
Chicago
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A., Suzuki, T., Takiguchi, Y., Hanazawa, T., Ishii, I."Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study". Oncology Letters 23, no. 5 (2022): 152. https://doi.org/10.3892/ol.2022.13271
Copy and paste a formatted citation
x
Spandidos Publications style
Imai C, Saeki H, Yamamoto K, Ichikawa A, Arai M, Tawada A, Suzuki T, Takiguchi Y, Hanazawa T, Ishii I, Ishii I, et al: Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study. Oncol Lett 23: 152, 2022.
APA
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A. ... Ishii, I. (2022). Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study. Oncology Letters, 23, 152. https://doi.org/10.3892/ol.2022.13271
MLA
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A., Suzuki, T., Takiguchi, Y., Hanazawa, T., Ishii, I."Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study". Oncology Letters 23.5 (2022): 152.
Chicago
Imai, C., Saeki, H., Yamamoto, K., Ichikawa, A., Arai, M., Tawada, A., Suzuki, T., Takiguchi, Y., Hanazawa, T., Ishii, I."Radiotherapy plus cetuximab for locally advanced squamous cell head and neck cancer in patients with cisplatin‑ineligible renal dysfunction: A retrospective study". Oncology Letters 23, no. 5 (2022): 152. https://doi.org/10.3892/ol.2022.13271
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