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An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy

  • Authors:
    • Koji Harada
    • Tarannum Ferdous
    • Rieko Fujiwara
    • Kenji Watanabe
    • Yoichi Mizukami
    • Katsuaki Mishima
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755‑8505, Japan, Center for Gene Research, Yamaguchi University, Ube, Yamaguchi 755‑8505, Japan
    Copyright: © Harada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 178
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    Published online on: April 14, 2022
       https://doi.org/10.3892/ol.2022.13298
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Abstract

An elemental diet (ED) reduces adverse effects of chemotherapy, including oral mucositis, in patients with cancer. However, the detailed mechanism(s) of the healing effects of an ED remains unclear. In the present study, the protective effects of the ED, Elental®, were examined against 5‑fluorouracil (5‑FU)‑induced oral mucositis and salivary gland atrophy in mice. Mucositis was induced in female ICR mice by injection of 5‑FU. The mice were orally administered Elental® (ED group) or saline (control group). After treatment, the mice body weight, salivary gland weight and the histological changes in the salivary gland granular duct area were monitored. The mice body weight remained stable in the ED group, but was significantly decreased in the control group. Moreover, the salivary gland weight was higher in the ED group compared with the control group. In addition, the salivary gland granular duct area cells were larger in the ED group compared with the control group. Whole transcriptome analysis and network analysis were conducted to understand the mechanisms of action of Elental® against oral mucositis. Whole transcriptome analysis and Ingenuity Pathways Analysis data suggested that Elental® contributed to the recovery of mitochondrial function in 5‑FU‑damaged salivary glands. Immunohistochemical analysis of salivary gland tissue demonstrated that the expression of cytochrome c oxidase subunit 4 and epidermal growth factor were higher in the ED group compared with the control group. Next, the rate of apoptosis in the salivary glands was examined using terminal deoxynucleotidyl transferase‑mediated nick end labeling (TUNEL) assays. The number of TUNEL‑positive cells in the salivary glands was lower in the ED group compared with the control group. These findings suggested that Elental® may protect mouse salivary glands from 5‑FU‑induced atrophic changes, which suggests that ED treatment may improve xerostomia and alleviate oral mucositis in patients with cancer receiving 5‑FU‑based chemotherapy.
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View References

1 

Epstein JB, Thariat J, Bensadoun RJ, Barasch A, Murphy BA, Kolnick L, Popplewell L and Maghami E: Oral complications of cancer and cancer therapy: From cancer treatment to survivorship. CA Cancer J Clin. 62:400–422. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Pulito C, Cristaudo A, Porta C, Zapperi S, Blandino G, Morrone A and Stranoet S: Oral mucositis: The hidden side of cancer therapy. J Exp Clin Cancer Res. 39:2102020. View Article : Google Scholar : PubMed/NCBI

3 

Tanaka Y, Takeuchi H, Nakashima Y, Nagano H, Ueno T, Tomizuka K, Morita S, Emi Y, Hamai Y, Hihara J, et al: Effects of an elemental diet to reduce adverse events in patients with esophageal cancer receiving docetaxel/cisplatin/5-fluorouracil: A phase III randomized controlled trial-EPOC 2 (JFMC49-1601-C5). ESMO Open. 6:1002772021. View Article : Google Scholar : PubMed/NCBI

4 

Reyes-Gibby CC, Melkonian SC, Wang J, Yu RK, Shelburne SA, Lu C, Gunn GB, Chambers MS, Hanna EY, Yeung SJ and Shete S: Identifying novel genes and biological processes relevant to the development of cancer therapy-induced mucositis: An informative gene network analysis. PLoS One. 12:e01803962017. View Article : Google Scholar : PubMed/NCBI

5 

Sayles C, Hickerson SC, Bhat RR, Hall J, Garey KW and Trivedi MV: Oral glutamine in preventing treatment-related mucositis in adult patients with cancer: A systematic review. Nutr Clin Pract. 31:171–179. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, et al: MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 120:1453–1461. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Abdel Moneim AE, Guerra-Librero A, Florido J, Shen YQ, Fernández-Gil B, Acuña-Castroviejo D and Escames G: Oral mucositis: Melatonin gel an effective new treatment. Int J Mol Sci. 18:10032017. View Article : Google Scholar : PubMed/NCBI

8 

Kyllo RL and Anadkat MJ: Dermatologic adverse events to chemotherapeutic agents, part 1: Cytotoxics, epidermal growth factor receptors, multikinase inhibitors, and proteasome inhibitors. Semin Cutan Med Surg. 33:28–39. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE, Migliorati CA, McGuire DB, Hutchins RD and Peterson DE; Mucositis Study Section of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology, . Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer. 109:820–831. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Peterson DE, Bensadoun RJ and Roila F; ESMO Guidelines Working Group, : Management of oral and gastrointestinal mucositis: ESMO clinical recommendations. Ann Oncol. 20 (Suppl 4):S174–S177. 2009. View Article : Google Scholar

11 

Henke M, Alfonsi M, Foa P, Giralt J, Bardet E, Cerezo L, Salzwimmer M, Lizambri R, Emmerson L, Chen MG and Berger D: Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: A randomized, placebo-controlled trial. J Clin Oncol. 29:2815–2820. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Bensinger W, Schubert M, Ang KK, Brizel D, Brown E, Eilers JG, Elting L, Mittal BB, Schattner MA, Spielberger R, et al: NCCN task force report. Prevention and management of mucositis in cancer care. J Natl Compr Canc Netw. 6 (Suppl 1):S1–S24. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Svanberg A, Ohrn K and Birgegård G: Oral cryotherapy reduces mucositis and improves nutrition-a randomised controlled trial. J Clin Nurs. 19:2146–2151. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Scully C, Epstein J and Sonis S: Oral mucositis: A challenging complication of radiotherapy, chemotherapy, and radiochemotherapy. Part 2: Diagnosis and management of mucositis. Head Neck. 26:77–84. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Yamamoto T, Nakahigashi M, Umegae S, Kitagawa T and Matsumoto K: Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: Cytokine production and endoscopic and histological findings. Inflamm Bowel Dis. 11:580–588. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Ishikawa T, Yasuda T, Doi T, Okayama T, Sakamoto N, Gen Y, Dohi O, Yoshida N, Kamada K, Uchiyama K, et al: The amino acid-rich elemental diet Elental® preserves lean body mass during chemo- or chemoradiotherapy for esophageal cancer. Oncol Rep. 36:1093–1100. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Yamamoto T, Nakahigashi M, Saniabadi AR, Iwata T, Maruyama Y, Umegae S and Matsumoto K: Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn's disease: A prospective study. Inflamm Bowel Dis. 13:1493–1501. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Yamamoto T, Nakahigashi M, Umegae S, Kitagawa T and Matsumoto K: Impact of long-term enteral nutrition on clinical and endoscopic recurrence after resection for Crohn's disease: A prospective, non-randomized, parallel, controlled study. Aliment Pharmacol Ther. 25:67–72. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Fukui T, Itoh Y, Orihara M, Yoshizawa K, Takeda H, Kawada S and Yoshioka T: Elental prevented and reduced oral mucositis during chemotherapy in patients esophageal cancer. Gan To Kagaku Ryoho. 38:2597–2601. 2011.(In Japanese). PubMed/NCBI

20 

Ogata Y, Takeuchi M, Ishibashi N, Kibe S, Takahashi K, Uchida S, Murakami N, Yahara T and Shirouzu K: Efficacy of Elental on prevention for chemotherapy-induced oral mucositis in colorectal cancer patients. Gan To Kagaku Ryoho. 39:583–587. 2012.(In Japanese). PubMed/NCBI

21 

Harada K, Ferdous T, Horinaga D, Uchida K, Mano T, Mishima K, Park S, Hanazawa H, Takahashi S, Okita A, et al: Efficacy of elemental diet on prevention for chemoradiotherapy-induced oral mucositis in patients with oral squamous cell carcinoma. Support Care Cancer. 24:953–959. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Harada K, Minami H, Ferdous T, Kato Y, Umeda H, Horinaga D, Uchida K, Park SC, Hanazawa H, Takahashi S, et al: The Elental® elemental diet for chemoradiotherapy-induced oral mucositis: A prospective study in patients with oral squamous cell carcinoma. Mol Clin Oncol. 10:159–167. 2019.PubMed/NCBI

23 

Hüttemann M, Helling S, Sanderson TH, Sinkler C, Samavati L, Mahapatra G, Varughese A, Lu G, Liu J, Ramzan R, et al: Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation. Biochim Biophys Acta. 1817:598–609. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Bikas A, Jensen K, Patel A, Costello J, Reynolds SM, Mendonca-Torres MC, Thakur S, Klubo-Gwiezdzinska J, Ylli D, Wartofsky L, et al: Cytochrome C oxidase subunit 4 (COX4): A potential therapeutic target for the treatment of medullary thyroid cancer. Cancers (Basel). 12:25482020. View Article : Google Scholar : PubMed/NCBI

25 

Vogt S, Ruppert V, Pankuweit S, Paletta JPJ, Rhiel A, Weber P, Irqsusi M, Cybulski P and Ramzan R: Myocardial insufficiency is related to reduced subunit 4 content of cytochrome c oxidase. J Cardiothorac Surg. 13:952018. View Article : Google Scholar : PubMed/NCBI

26 

Li Y, Park JS, Deng JH and Bai Y: Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. J Bioenerg Biomembr. 38:283–291. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Cano Sanchez M, Lancel S, Boulanger E and Neviere R: Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: A systematic review. Antioxidants (Basel). 7:982018. View Article : Google Scholar : PubMed/NCBI

28 

Hoffmann RF, Jonker MR, Brandenburg SM, de Bruin HG, Ten Hacken NHT, van Oosterhout AJM and Heijink IH: Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium. Sci Rep. 9:150472019. View Article : Google Scholar : PubMed/NCBI

29 

Saegusa Y, Ichikawa T, Iwai T, Goso Y, Ikezawa T, Nakano M, Shikama N, Saigenji K and Ishihara K: Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis. Scand J Gastroenterol. 43:531–537. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Stempniewicz A, Ceranowicz P and Warzecha Z: Potential therapeutic effects of gut hormones, ghrelin and obestatin in oral mucositis. Int J Mol Sci. 20:15342019. View Article : Google Scholar : PubMed/NCBI

31 

Van Leeuwen SJM, Proctor GB, Laheij AMGA, Potting CMJ, Smits O, Bronkhorst EM, Hazenberg MD, Haverman TM, Brennan MT, Von Bültzingslöwen I, et al: Significant salivary changes in relation to oral mucositis following autologous hematopoietic stem cell transplantation. Bone Marrow Transplant. 56:1381–1390. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Dumbrigue HB, Sandow PL, Nguyen KH and Humphreys-Beher MG: Salivary epidermal growth factor levels decrease in patients receiving radiation therapy to the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 89:710–716. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Harrison T, Bigler L, Tucci M, Pratt L, Malamud F, Thigpen JT, Streckfus C and Younger H: Salivary sIgA concentrations and stimulated whole saliva flow rates among women undergoing chemotherapy for breast cancer: An exploratory study. Spec Care Dentist. 18:109–112. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Brand HS, Ligtenberg AJ and Veerman EC: Saliva and wound healing. Monogr Oral Sci. 24:52–60. 2014. View Article : Google Scholar : PubMed/NCBI

35 

McCarthy GM, Awde JD, Ghandi H, Vincent M and Kocha WI: Risk factors associated with mucositis in cancer patients receiving 5-fluorouracil. Oral Oncol. 34:484–490. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Epstein JB, Tsang AH, Warkentin D and Ship JA: The role of salivary function in modulating chemotherapy-induced oropharyngeal mucositis: A review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 94:39–44. 2002. View Article : Google Scholar : PubMed/NCBI

37 

QIAGEN, . Online Ingenuity Knowledge Base-Articles. https://qiagen.secure.force.com/KnowledgeBase/KnowledgeIPAPage?id=kA41i000000L5sBFebruary 27–2022

38 

Wie SM, Wellberg E, Karam SD and Reyland ME: Tyrosine kinase inhibitors protect the salivary gland from radiation damage by inhibiting activation of protein kinase C-δ. Mol Cancer Ther. 16:1989–1998. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Kawashima R, Fujimaki M, Ikenoue Y, Danjo K, Koizumi W and Ichikawa T: Influence of an elemental diet on 5-fluorouracil-induced morphological changes in the mouse salivary gland and colon. Support Care Cancer. 24:1609–1616. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Fujiwara R, Harada K, Ferdous T and Mishima K: Amino acids may have protective effects on salivary glands of 5-FU-administered mice. In Vivo. 36:198–205. 2022. View Article : Google Scholar : PubMed/NCBI

41 

Jensen SB, Pedersen AM, Reibel J and Nauntofte B: Xerostomia and hypofunction of the salivary glands in cancer therapy. Support Care Cancer. 11:207–225. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Harada K, Ferdous T, Kobayashi H and Ueyama Y: Elemental diet accelerates the recovery from oral mucositis and dermatitis induced by 5-fluorouracil through the induction of fibroblast growth factor 2. Integr Cancer Ther. 17:423–430. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Harada K, Takenawa T, Ferdous T, Mizukami Y and Mishima K: Elemental diet directly affects chemotherapy-induced dermatitis and raw wound areas. Mol Clin Oncol. 13:209–215. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Hao YH, Zhang J, Wang H, Wang HY, Dong J, Xu XP, Yao BW, Wang LF, Zhou HM, Zhao L and Peng RY: HIF-1α regulates COXIV subunits, a potential mechanism of self-protective response to microwave induced mitochondrial damages in neurons. Sci Rep. 8:104032018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Harada K, Ferdous T, Fujiwara R, Watanabe K, Mizukami Y and Mishima K: An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy. Oncol Lett 23: 178, 2022.
APA
Harada, K., Ferdous, T., Fujiwara, R., Watanabe, K., Mizukami, Y., & Mishima, K. (2022). An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy. Oncology Letters, 23, 178. https://doi.org/10.3892/ol.2022.13298
MLA
Harada, K., Ferdous, T., Fujiwara, R., Watanabe, K., Mizukami, Y., Mishima, K."An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy". Oncology Letters 23.6 (2022): 178.
Chicago
Harada, K., Ferdous, T., Fujiwara, R., Watanabe, K., Mizukami, Y., Mishima, K."An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy". Oncology Letters 23, no. 6 (2022): 178. https://doi.org/10.3892/ol.2022.13298
Copy and paste a formatted citation
x
Spandidos Publications style
Harada K, Ferdous T, Fujiwara R, Watanabe K, Mizukami Y and Mishima K: An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy. Oncol Lett 23: 178, 2022.
APA
Harada, K., Ferdous, T., Fujiwara, R., Watanabe, K., Mizukami, Y., & Mishima, K. (2022). An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy. Oncology Letters, 23, 178. https://doi.org/10.3892/ol.2022.13298
MLA
Harada, K., Ferdous, T., Fujiwara, R., Watanabe, K., Mizukami, Y., Mishima, K."An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy". Oncology Letters 23.6 (2022): 178.
Chicago
Harada, K., Ferdous, T., Fujiwara, R., Watanabe, K., Mizukami, Y., Mishima, K."An elemental diet protects mouse salivary glands from 5‑fluorouracil‑induced atrophy". Oncology Letters 23, no. 6 (2022): 178. https://doi.org/10.3892/ol.2022.13298
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