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Article Open Access

Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer

  • Authors:
    • Nannan Liu
    • Dongxue Qi
    • Jing Jiang
    • Jihong Zhang
    • Chunyan Yu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, College of Basic Medicine, Beihua University, Jilin 132013, P.R. China, Department of Pathology, Lianyungang First People's Hospital, Lianyungang, Jiangsu 222000, P.R. China, Department of Pathology, Affiliated Hospital of Beihua University, Jilin 132011, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 193
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    Published online on: April 29, 2022
       https://doi.org/10.3892/ol.2022.13313
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Abstract

Compared with other types of breast cancer, triple‑negative breast cancer (TNBC) has the characteristics of rapid progression, a lack of specific molecular targets for treatment and a poor prognosis. However, based on previously published studies, TGF‑β1 and survivin are potentially meaningful for the prognosis of patients with TNBC. The present study was therefore designed to measure and compare the expression of transforming growth factor‑β1 (TGF‑β1) and survivin in tissue samples of TNBC and non‑TNBC patients in order to evaluate their ability as prognostic indicators. In total, 90 TNBC and 52 non‑TNBC tissue specimens were selected, following which immunohistochemistry was used to detect the expression of TGF‑β1 and survivin in the cancer tissues. Subsequently, the potential association between the expression levels of these two proteins and the clinicopathological variables was analyzed. The expression levels of TGF‑β1 and survivin in TNBC tissues were found to be significantly higher compared with those in the non‑TNBC tissues. In addition, the results of the present study demonstrated that TGF‑β1 expression was positively associated with survivin expression in the TNBC samples, but no significant correlation was found between TGF‑β1 and survivin expression in the non‑TNBC samples. Kaplan‑Meier (K‑M) analysis was performed to assess the levels of TGF‑β1 and survivin in regard to patient survival, and univariate and multivariate Cox analyses of TGF‑β1 and survivin protein expression were performed to analyze the overall survival (OS) and progression‑free survival (PFS) rates of patients with TNBC and non‑TNBC. Although multivariate Cox analysis demonstrated that neither TGF‑β1 or survivin were independent prognostic predictors of TNBC or non‑TNBC, results of the K‑M curve revealed that patients with TNBC with TGF‑β1‑ and survivin‑positive breast cancer exhibited shorter OS and PFS times. Multivariate Cox analysis demonstrated that in patients with TNBC, the combined expression of TGF‑β1 and survivin may yield additional prognostic information, compared with patients with non‑TNBC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu N, Qi D, Jiang J, Zhang J and Yu C: Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer. Oncol Lett 23: 193, 2022.
APA
Liu, N., Qi, D., Jiang, J., Zhang, J., & Yu, C. (2022). Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer. Oncology Letters, 23, 193. https://doi.org/10.3892/ol.2022.13313
MLA
Liu, N., Qi, D., Jiang, J., Zhang, J., Yu, C."Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer". Oncology Letters 23.6 (2022): 193.
Chicago
Liu, N., Qi, D., Jiang, J., Zhang, J., Yu, C."Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer". Oncology Letters 23, no. 6 (2022): 193. https://doi.org/10.3892/ol.2022.13313
Copy and paste a formatted citation
x
Spandidos Publications style
Liu N, Qi D, Jiang J, Zhang J and Yu C: Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer. Oncol Lett 23: 193, 2022.
APA
Liu, N., Qi, D., Jiang, J., Zhang, J., & Yu, C. (2022). Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer. Oncology Letters, 23, 193. https://doi.org/10.3892/ol.2022.13313
MLA
Liu, N., Qi, D., Jiang, J., Zhang, J., Yu, C."Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer". Oncology Letters 23.6 (2022): 193.
Chicago
Liu, N., Qi, D., Jiang, J., Zhang, J., Yu, C."Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer". Oncology Letters 23, no. 6 (2022): 193. https://doi.org/10.3892/ol.2022.13313
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