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Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma

  • Authors:
    • Yasuhiro Adachi
    • Norihiro Sato
    • Takuya Oba
    • Takao Amaike
    • Yuzan Kudo
    • Shiro Kohi
    • Toshiyuki Nakayama
    • Keiji Hirata
  • View Affiliations / Copyright

    Affiliations: Department of Surgery I, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan, Department of Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan
    Copyright: © Adachi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 222
    |
    Published online on: May 23, 2022
       https://doi.org/10.3892/ol.2022.13343
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Abstract

Hyaluronan‑binding protein 1 (HABP1) is among the molecules known to bind to hyaluronan and is involved in a variety of cellular processes, including cell proliferation and migration. HABP1 has been implicated in the progression of various cancers; however, there have been (to the best of our knowledge) few studies on the expression and function of HABP1 in pancreatic ductal adenocarcinoma (PDAC), a topic that is examined in the present study. Immunohistochemical analysis of HABP1 protein was conducted in archival tissues from 105 patients with PDAC. Furthermore, the functional effect of HABP1 on proliferation, colony formation, and migration in PDAC cells was examined by knockdown of HABP1. It was revealed that HABP1 was overexpressed in 49 (46.2%) out of 105 patients with PDAC. Overall survival was significantly shorter in patients with high HABP1 expression than in those with low HABP1 expression (median survival time of 12.8 months vs. 28.5 months; log‑rank test, P=0.004). Knockdown of HABP1 expression in PDAC cells resulted in decreased cell proliferation, colony formation, and cell migration activity. Thus, HABP1 may serve as a prognostic factor in PDAC and may be of use as a novel therapeutic target.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

National Cancer Center Japan, . Cancer Registry and Statistics. Cancer Information Service. https://ganjoho.jp/en/index.html1–March. 2022

3 

Michl P and Gress TM: Improving drug delivery to pancreatic cancer: Breaching the stromal fortress by targeting hyaluronic acid. Gut. 61:1377–1379. 2012. View Article : Google Scholar

4 

Cheng XB, Kohi S, Koga A, Hirata K and Sato N: Hyaluronan stimulates pancreatic cancer cell motility. Oncotarget. 7:4829–4840. 2016. View Article : Google Scholar

5 

Itano N, Zhuo L and Kimata K: Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression. Cancer Sci. 99:1720–1725. 2008. View Article : Google Scholar

6 

Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, Feig C, Nakagawa T, Caldwell ME, Zecchini HI, et al: Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut. 62:112–120. 2013. View Article : Google Scholar

7 

Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD and Hingorani SR: Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 21:418–429. 2012. View Article : Google Scholar

8 

Sato N, Kohi S, Hirata K and Goggins M: Role of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlight. Cancer Sci. 107:569–575. 2016. View Article : Google Scholar

9 

Sironen RK, Tammi M, Tammi R, Auvinen PK, Anttila M and Kosma VM: Hyaluronan in human malignancies. Exp Cell Res. 317:383–391. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Toole BP, Wight TN and Tammi MI: Hyaluronan-cell interactions in cancer and vascular disease. J Biol Chem. 277:4593–4596. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Du Y, Cao M, Liu Y, He Y, Yang C, Wu M, Zhang G and Gao F: Low-molecular-weight hyaluronan (LMW-HA) accelerates lymph node metastasis of melanoma cells by inducing disruption of lymphatic intercellular adhesion. Oncoimmunology. 5:e12322352016. View Article : Google Scholar : PubMed/NCBI

12 

Liu M, Tolg C and Turley E: Dissecting the dual nature of hyaluronan in the tumor microenvironment. Front Immunol. 10:9472019. View Article : Google Scholar

13 

Sugahara KN, Hirata T, Hayasaka H, Stern R, Murai T and Miyasaka M: Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments. J Biol Chem. 281:5861–5868. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Wu M, Cao M, He Y, Liu Y, Yang C, Du Y, Wang W and Gao F: A novel role of low molecular weight hyaluronan in breast cancer metastasis. FASEB J. 29:1290–1298. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Cheng XB, Sato N, Kohi S and Yamaguchi K: Prognostic impact of hyaluronan and its regulators in pancreatic ductal adenocarcinoma. PLoS One. 8:e807652013. View Article : Google Scholar : PubMed/NCBI

16 

Kohi S, Sato N, Cheng XB, Koga A and Hirata K: Increased expression of HYAL1 in pancreatic ductal adenocarcinoma. Pancreas. 45:1467–1473. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Chowdhury AR, Ghosh I and Datta K: Excessive reactive oxygen species induces apoptosis in fibroblasts: Role of mitochondrially accumulated hyaluronic acid binding protein 1 (HABP1/p32/gC1qR). Exp Cell Res. 314:651–667. 2008. View Article : Google Scholar : PubMed/NCBI

18 

D'Souza M and Datta K: A novel glycoprotein that binds to hyaluronic acid. Biochem Int. 13:79–88. 1986.

19 

Li K, Gao B, Li J, Chen H, Li Y, Wei Y, Gong D, Gao J, Zhang J, Tan W, et al: ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription. Oncotarget. 6:38107–38126. 2015. View Article : Google Scholar

20 

Li Y, Wan OW, Xie W and Chung KK: p32 regulates mitochondrial morphology and dynamics through Parkin. Neuroscience. 199:346–358. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Liu Y, Leslie PL, Jin A, Itahana K, Graves LM and Zhang Y: p32 heterozygosity protects against age- and diet-induced obesity by increasing energy expenditure. Sci Rep. 7:57542017. View Article : Google Scholar : PubMed/NCBI

22 

Liu Y, Leslie PL, Jin A, Itahana K, Graves LM and Zhang Y: p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression. FASEB J. 32:3892–3902. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Muta T, Kang D, Kitajima S, Fujiwara T and Hamasaki N: p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation. J Biol Chem. 272:24363–24370. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Saha P and Datta K: Multi-functional, multicompartmental hyaluronan-binding protein 1 (HABP1/p32/gC1qR): Implication in cancer progression and metastasis. Oncotarget. 9:10784–10807. 2018. View Article : Google Scholar

25 

Xie ZB, Yao L, Jin C, Zhang YF and Fu DL: High cytoplasm HABP1 expression as a predictor of poor survival and late tumor stage in pancreatic ductal adenocarcinoma patients. Eur J Surg Oncol. 45:207–212. 2019. View Article : Google Scholar

26 

Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida S, Kanki T and Kang D: p32/gC1qR is indispensable for fetal development and mitochondrial translation: Importance of its RNA-binding ability. Nucleic Acids Res. 40:9717–9737. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Kaul R, Saha P, Saradhi M, Prasad RL, Chatterjee S, Ghosh I, Tyagi RK and Datta K: Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway. J Biol Chem. 287:19750–19764. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Saha P, Ghosh I and Datta K: Increased hyaluronan levels in HABP1/p32/gC1qR overexpressing HepG2 cells inhibit autophagic vacuolation regulating tumor potency. PLoS One. 9:e1032082014. View Article : Google Scholar : PubMed/NCBI

29 

Brierley JD, Gospodarowicz MK and Wittekind C: TNM classification of malignant tumours. 8th edition. John Wiley & Sons; 2017

30 

Wang J, Song Y, Liu T, Shi Q, Zhong Z, Wei W, Huang S and Pang D: Elevated expression of HABP1 is a novel prognostic indicator in triple-negative breast cancers. Tumour Biol. 36:4793–4799. 2015. View Article : Google Scholar

31 

Sato N, Mizumoto K, Beppu K, Maehara N, Kusumoto M, Nabae T, Morisaki T, Katano M and Tanaka M: Establishment of a new human pancreatic cancer cell line, NOR-P1, with high angiogenic activity and metastatic potential. Cancer Lett. 155:153–161. 2000. View Article : Google Scholar

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Vikramdeo KS, Saha P, Dutta S, Kumar N, Roy Chowdhury A, Kumar S, Tyagi RK, Ghosh I and Datta K: Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells. Cell Biol Int. 44:1312–1330. 2020. View Article : Google Scholar

34 

Prakash M, Kale S, Ghosh I, Kundu GC and Datta K: Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappaB dependent MMP-2 activation through integrin α(v)β(3) interaction. Cell Signal. 23:1563–1577. 2011. View Article : Google Scholar

35 

Niu M, Sun S, Zhang G, Zhao Y, Pang D and Chen Y: Elevated expression of HABP1 is correlated with metastasis and poor survival in breast cancer patients. Am J Cancer Res. 5:1190–1198. 2015.PubMed/NCBI

36 

Yu H, Liu Q, Xin T, Xing L, Dong G, Jiang Q, Lv Y, Song X, Teng C, Huang D, et al: Elevated expression of hyaluronic acid binding protein 1 (HABP1)/P32/C1QBP is a novel indicator for lymph node and peritoneal metastasis of epithelial ovarian cancer patients. Tumour Biol. 34:3981–3987. 2013. View Article : Google Scholar

37 

Gao H, Yao Q, Lan X, Li S, Wu J, Zeng G and Xue Y: Elevated HABP1 protein expression correlates with progression and poor survival in patients with gastric cancer. Onco Targets Ther. 9:6711–6718. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Zhang M, Li N, Liang Y, Liu J, Zhou Y and Liu C: Hyaluronic acid binding protein 1 overexpression is an indicator for disease-free survival in cervical cancer. Int J Clin Oncol. 22:347–352. 2017. View Article : Google Scholar

39 

Jiang Y, Wu H, Liu J, Chen Y, Xie J, Zhao Y and Pang D: Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women. Oncotarget. 8:13932–13941. 2017. View Article : Google Scholar

40 

Zhao J, Liu T, Yu G and Wang J: Overexpression of HABP1 correlated with clinicopathological characteristics and unfavorable prognosis in endometrial cancer. Tumour Biol. 36:1299–1306. 2015. View Article : Google Scholar

41 

Li X, Eguchi T, Aly RG, Chintala NK, Tan KS, Zauderer MG, Dembitzer FR, Beasley MB, Ghebrehiwet B, Adusumilli PS and Peerschke EIB: Globular C1q receptor (gC1qR/p32/HABP1) is overexpressed in malignant pleural mesothelioma and is associated with increased survival in surgical patients treated with chemotherapy. Front Oncol. 9:10422019. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Adachi Y, Sato N, Oba T, Amaike T, Kudo Y, Kohi S, Nakayama T and Hirata K: Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma. Oncol Lett 24: 222, 2022.
APA
Adachi, Y., Sato, N., Oba, T., Amaike, T., Kudo, Y., Kohi, S. ... Hirata, K. (2022). Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma. Oncology Letters, 24, 222. https://doi.org/10.3892/ol.2022.13343
MLA
Adachi, Y., Sato, N., Oba, T., Amaike, T., Kudo, Y., Kohi, S., Nakayama, T., Hirata, K."Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma". Oncology Letters 24.1 (2022): 222.
Chicago
Adachi, Y., Sato, N., Oba, T., Amaike, T., Kudo, Y., Kohi, S., Nakayama, T., Hirata, K."Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma". Oncology Letters 24, no. 1 (2022): 222. https://doi.org/10.3892/ol.2022.13343
Copy and paste a formatted citation
x
Spandidos Publications style
Adachi Y, Sato N, Oba T, Amaike T, Kudo Y, Kohi S, Nakayama T and Hirata K: Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma. Oncol Lett 24: 222, 2022.
APA
Adachi, Y., Sato, N., Oba, T., Amaike, T., Kudo, Y., Kohi, S. ... Hirata, K. (2022). Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma. Oncology Letters, 24, 222. https://doi.org/10.3892/ol.2022.13343
MLA
Adachi, Y., Sato, N., Oba, T., Amaike, T., Kudo, Y., Kohi, S., Nakayama, T., Hirata, K."Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma". Oncology Letters 24.1 (2022): 222.
Chicago
Adachi, Y., Sato, N., Oba, T., Amaike, T., Kudo, Y., Kohi, S., Nakayama, T., Hirata, K."Prognostic and functional role of hyaluronan‑binding protein 1 in pancreatic ductal adenocarcinoma". Oncology Letters 24, no. 1 (2022): 222. https://doi.org/10.3892/ol.2022.13343
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