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Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy

  • Authors:
    • Chia-Lin Chang
    • Kevin Chih-Yang Huang
    • Tsung-Wei Chen
    • William Tzu-Liang Chen
    • Hsuan-Hua Huang
    • Ya-Ling Liu
    • Chia-Hui Kuo
    • K.S. Clifford Chao
    • Tao-Wei Ke
    • Shu-Fen Chiang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C., Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 40402, Taiwan, R.O.C., Graduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan, R.O.C., Department of Colorectal Surgery, Hsinchu China Medical University Hospital, Hsinchu 30272, Taiwan, R.O.C., Department of Pathology, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C., Laboratory of Precision Medicine, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C., Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, R.O.C.
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 238
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    Published online on: May 31, 2022
       https://doi.org/10.3892/ol.2022.13358
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Abstract

Rectal adenocarcinoma (READ) constitutes one‑third of newly diagnosed colorectal cancer cases. Surgery, chemotherapy and concurrent chemoradiotherapy are the main treatments to improve patient outcomes for READ. However, patients with READ receiving these treatments eventually relapse, leading to a poor survival outcome. The present study collected surgical specimens from patients with READ and determined that cytoplasmic cell division cycle 27 (CDC27) expression was associated with the risk of lymph node metastasis and distant metastasis. Nuclear CDC27 expression was negatively associated with 5‑year disease‑free survival (DFS) and 5‑year overall survival (OS) rates. Multivariate Cox proportional regression analysis showed that nuclear CDC27 was an independent prognostic factor in the patients with READ, especially in those treated with adjuvant chemotherapy. High nuclear CDC27 expression was significantly associated with poorer 5‑year DFS (HR, 2.106; 95% CI, 1.275‑3.570; P=0.003) and 5‑year OS (HR, 2.369; 95% CI, 1.270‑4.6810; P=0.005) rates. The data indicated that cytoplasmic CDC27 expression could affect tumor progression and that it plays an important role in metastasis. Nuclear CDC27 expression was markedly associated with poorer survival outcomes and was an independent prognostic factor in patients with postoperative adjuvant chemotherapy‑treated READ. Thus, CDC27 expression serves as a potential prognostic marker for rectal tumor progression and chemotherapy treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Chang C, Huang KC, Chen T, Chen WT, Huang H, Liu Y, Kuo C, Chao KC, Ke T, Chiang S, Chiang S, et al: Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy. Oncol Lett 24: 238, 2022.
APA
Chang, C., Huang, K.C., Chen, T., Chen, W.T., Huang, H., Liu, Y. ... Chiang, S. (2022). Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy. Oncology Letters, 24, 238. https://doi.org/10.3892/ol.2022.13358
MLA
Chang, C., Huang, K. C., Chen, T., Chen, W. T., Huang, H., Liu, Y., Kuo, C., Chao, K. C., Ke, T., Chiang, S."Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy". Oncology Letters 24.1 (2022): 238.
Chicago
Chang, C., Huang, K. C., Chen, T., Chen, W. T., Huang, H., Liu, Y., Kuo, C., Chao, K. C., Ke, T., Chiang, S."Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy". Oncology Letters 24, no. 1 (2022): 238. https://doi.org/10.3892/ol.2022.13358
Copy and paste a formatted citation
x
Spandidos Publications style
Chang C, Huang KC, Chen T, Chen WT, Huang H, Liu Y, Kuo C, Chao KC, Ke T, Chiang S, Chiang S, et al: Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy. Oncol Lett 24: 238, 2022.
APA
Chang, C., Huang, K.C., Chen, T., Chen, W.T., Huang, H., Liu, Y. ... Chiang, S. (2022). Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy. Oncology Letters, 24, 238. https://doi.org/10.3892/ol.2022.13358
MLA
Chang, C., Huang, K. C., Chen, T., Chen, W. T., Huang, H., Liu, Y., Kuo, C., Chao, K. C., Ke, T., Chiang, S."Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy". Oncology Letters 24.1 (2022): 238.
Chicago
Chang, C., Huang, K. C., Chen, T., Chen, W. T., Huang, H., Liu, Y., Kuo, C., Chao, K. C., Ke, T., Chiang, S."Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy". Oncology Letters 24, no. 1 (2022): 238. https://doi.org/10.3892/ol.2022.13358
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