Open Access

IDH2: A novel biomarker for environmental exposure in blood circulatory system disorders (Review)

  • Authors:
    • Ya Qi Gong
    • Shuang Wei
    • Yuan Yun Wei
    • Yong Lin Chen
    • Jian Cui
    • Yue Qiu Yu
    • Xiang Lin
    • Hong Xia Yan
    • Hui Qin
    • Lan Yi
  • View Affiliations

  • Published online on: June 24, 2022     https://doi.org/10.3892/ol.2022.13398
  • Article Number: 278
  • Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As the risk of harmful environmental exposure is increasing, it is important to find suitable targets for the diagnosis and treatment of the diseases caused. Isocitrate dehydrogenase 2 (IDH2) is an enzyme located in the mitochondria; it plays an important role in numerous cell processes, including maintaining redox homeostasis, participating in the tricarboxylic acid cycle and indirectly taking part in the transmission of the oxidative respiratory chain. IDH2 mutations promote progression in acute myeloid leukemia, glioma and other diseases. The present review mainly summarizes the role and mechanism of IDH2 with regard to the biological effects, such as the mitophagy and apoptosis of animal or human cells, caused by environmental pollution such as radiation, heavy metals and other environmental exposure factors. The possible mechanisms of these biological effects are described in terms of IDH2 expression, reduced nicotine adenine dinucleotide phosphate content and reactive oxygen species level, among other variables. The impact of environmental pollution on human health is increasingly attracting attention. IDH2 may therefore become useful as a potential diagnostic and therapeutic target for environmental exposure‑induced diseases.
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August-2022
Volume 24 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Gong YQ, Wei S, Wei YY, Chen YL, Cui J, Yu YQ, Lin X, Yan HX, Qin H, Yi L, Yi L, et al: IDH2: A novel biomarker for environmental exposure in blood circulatory system disorders (Review). Oncol Lett 24: 278, 2022
APA
Gong, Y.Q., Wei, S., Wei, Y.Y., Chen, Y.L., Cui, J., Yu, Y.Q. ... Yi, L. (2022). IDH2: A novel biomarker for environmental exposure in blood circulatory system disorders (Review). Oncology Letters, 24, 278. https://doi.org/10.3892/ol.2022.13398
MLA
Gong, Y. Q., Wei, S., Wei, Y. Y., Chen, Y. L., Cui, J., Yu, Y. Q., Lin, X., Yan, H. X., Qin, H., Yi, L."IDH2: A novel biomarker for environmental exposure in blood circulatory system disorders (Review)". Oncology Letters 24.2 (2022): 278.
Chicago
Gong, Y. Q., Wei, S., Wei, Y. Y., Chen, Y. L., Cui, J., Yu, Y. Q., Lin, X., Yan, H. X., Qin, H., Yi, L."IDH2: A novel biomarker for environmental exposure in blood circulatory system disorders (Review)". Oncology Letters 24, no. 2 (2022): 278. https://doi.org/10.3892/ol.2022.13398