Open Access

HS‑1793 inhibits cell proliferation in lung cancer by interfering with the interaction between p53 and MDM2

  • Authors:
    • Chungun Lim
    • Peter C.W. Lee
    • Sungbo Shim
    • Sung-Wuk Jang
  • View Affiliations

  • Published online on: July 1, 2022     https://doi.org/10.3892/ol.2022.13410
  • Article Number: 290
  • Copyright: © Lim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The transcription factor or tumor suppressor protein p53 regulates numerous cellular functions, including cell proliferation, invasion, migration, senescence and apoptosis, in various types of cancer. HS‑1793 is an analog of resveratrol, which exhibits anti‑cancer effects on various types of cancer, including breast, prostate, colon and renal cancer, and multiple myeloma. However, to the best of our knowledge, the role of HS‑1793 in lung cancer remains to be examined. The present study aimed to investigate the anti‑cancer effect of HS‑1793 on lung cancer and to determine its association with p53. The results revealed that HS‑1793 reduced cell proliferation in lung cancer and increased p53 stability, thereby elevating the expression levels of the target genes p21 and mouse double minute 2 homolog (MDM2). When the levels of MDM2, a negative regulator of p53, are increased under normal conditions, MDM2 binds and degrades p53; however, HS‑1793 inhibited this binding, confirming that p53 protein stability was increased. In conclusion, the findings of the present study provide new evidence that HS‑1793 may inhibit lung cancer proliferation by disrupting the p53‑MDM2 interaction.
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August-2022
Volume 24 Issue 2

Print ISSN: 1792-1074
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Spandidos Publications style
Lim C, Lee PC, Shim S and Jang S: HS‑1793 inhibits cell proliferation in lung cancer by interfering with the interaction between p53 and MDM2. Oncol Lett 24: 290, 2022
APA
Lim, C., Lee, P.C., Shim, S., & Jang, S. (2022). HS‑1793 inhibits cell proliferation in lung cancer by interfering with the interaction between p53 and MDM2. Oncology Letters, 24, 290. https://doi.org/10.3892/ol.2022.13410
MLA
Lim, C., Lee, P. C., Shim, S., Jang, S."HS‑1793 inhibits cell proliferation in lung cancer by interfering with the interaction between p53 and MDM2". Oncology Letters 24.2 (2022): 290.
Chicago
Lim, C., Lee, P. C., Shim, S., Jang, S."HS‑1793 inhibits cell proliferation in lung cancer by interfering with the interaction between p53 and MDM2". Oncology Letters 24, no. 2 (2022): 290. https://doi.org/10.3892/ol.2022.13410