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MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients

  • Authors:
    • Huina Lu
    • Yi Ding
    • Yan Dong
    • Xiu Luo
    • Xiuqin Wang
    • Bing Xiu
    • Aibin Liang
    • Wenjun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 330
    |
    Published online on: August 5, 2022
       https://doi.org/10.3892/ol.2022.13450
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Abstract

The present study aimed to explore the correlation of microRNA (miR)‑181b‑5p expression with treatment response and long‑term prognosis in acute myeloid leukemia (AML) patients. miR‑181b‑5p was detected in the bone marrow of 84 AML patients before therapy. After induction therapy, the patients exhibiting complete remission (CR) were recorded. Next, event‑free survival (EFS) and overall survival (OS) were calculated. miR‑181b‑5p had excellent potential to discriminate AML patients from healthy donors [area under the curve (AUC): 0.922, 95% confidence interval (CI): 0.873‑0.971)]. In addition, miR‑181b‑5p expression was decreased in AML patients with the FLT3‑ITD mutation (P=0.032) or WT1 mutation (P=0.017) when compared to AML patients without these genetic mutations. Meanwhile, miR‑181b‑5p expression was negatively correlated with the National Comprehensive Cancer Network (NCCN) risk classification of AML (P=0.036). Furthermore, miR‑181b‑5p expression was elevated in CR AML patients compared to non‑CR AML patients (P=0.030). Moreover, higher miR‑181b‑5p expression was associated with favorable accumulating EFS (P=0.001) and OS (P=0.024). In addition, higher miR‑181b‑5p expression was independently associated with better EFS (hazard ratio: 0.698, P=0.012). In conclusion, miR‑181b‑5p insufficiency is associated with induction therapy response failure, unfavorable accumulating EFS and OS in AML patients.
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Copy and paste a formatted citation
Spandidos Publications style
Lu H, Ding Y, Dong Y, Luo X, Wang X, Xiu B, Liang A and Zhang W: MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients. Oncol Lett 24: 330, 2022.
APA
Lu, H., Ding, Y., Dong, Y., Luo, X., Wang, X., Xiu, B. ... Zhang, W. (2022). MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients. Oncology Letters, 24, 330. https://doi.org/10.3892/ol.2022.13450
MLA
Lu, H., Ding, Y., Dong, Y., Luo, X., Wang, X., Xiu, B., Liang, A., Zhang, W."MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients". Oncology Letters 24.4 (2022): 330.
Chicago
Lu, H., Ding, Y., Dong, Y., Luo, X., Wang, X., Xiu, B., Liang, A., Zhang, W."MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients". Oncology Letters 24, no. 4 (2022): 330. https://doi.org/10.3892/ol.2022.13450
Copy and paste a formatted citation
x
Spandidos Publications style
Lu H, Ding Y, Dong Y, Luo X, Wang X, Xiu B, Liang A and Zhang W: MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients. Oncol Lett 24: 330, 2022.
APA
Lu, H., Ding, Y., Dong, Y., Luo, X., Wang, X., Xiu, B. ... Zhang, W. (2022). MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients. Oncology Letters, 24, 330. https://doi.org/10.3892/ol.2022.13450
MLA
Lu, H., Ding, Y., Dong, Y., Luo, X., Wang, X., Xiu, B., Liang, A., Zhang, W."MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients". Oncology Letters 24.4 (2022): 330.
Chicago
Lu, H., Ding, Y., Dong, Y., Luo, X., Wang, X., Xiu, B., Liang, A., Zhang, W."MicroRNA‑181b‑5p insufficiency predicts treatment response failure risk and unfavorable event‑free survival as well as overall survival in acute myeloid leukemia patients". Oncology Letters 24, no. 4 (2022): 330. https://doi.org/10.3892/ol.2022.13450
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