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Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer

  • Authors:
    • Akinori Wada
    • Mitsuhiro Narita
    • Masayuki Nagasawa
    • Takuto Kusaba
    • Shigehisa Kubota
    • Tetsuya Yoshida
    • Kazuyoshi Johnin
    • Akihiro Kawauchi
    • Susumu Kageyama
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
    Copyright: © Wada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 333
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    Published online on: August 9, 2022
       https://doi.org/10.3892/ol.2022.13453
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Abstract

The present study aimed to use real‑world Japanese data to compare the treatment outcome of conventional hormonal therapy to that of using androgen receptor axis‑targeted (ARAT) agents for patients with metastatic castration‑resistant prostate cancer. The overall survival between the conventional hormonal therapy group and the ARAT agent therapy group was compared using a group of 75 Japanese patients who were treated for metastatic castration‑resistant prostate cancer. A subgroup analysis was carried out and the risk factors that affected overall survival (OS) were determined. The median OS from the time of prostate‑specific antigen recurrence was 73.1 months in the ARAT group and 45.2 months in the conventional treatment group (P=0.414). Although OS tended to be slightly longer in the ARAT group, the difference between the groups was not significant. Subgroup analysis suggested that the therapeutic outcome of using ARAT agents tended to be less beneficial in patients who were older, and in those with a higher tumor volume or low Gleason grade. In conclusion, use of ARAT agents did not impart a significant survival benefit to patients with metastatic castration‑resistant prostate cancer when compared with survival rates in response to conventional therapy. However, there was some clinical benefit when ARAT agents were used after patients developed castration‑resistant prostate cancer. These findings suggest that up‑front therapy using ARAT agents at the time of the initial hormone therapy can impart clinical benefit in Japanese patients with metastatic prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wada A, Narita M, Nagasawa M, Kusaba T, Kubota S, Yoshida T, Johnin K, Kawauchi A and Kageyama S: Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer. Oncol Lett 24: 333, 2022.
APA
Wada, A., Narita, M., Nagasawa, M., Kusaba, T., Kubota, S., Yoshida, T. ... Kageyama, S. (2022). Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer. Oncology Letters, 24, 333. https://doi.org/10.3892/ol.2022.13453
MLA
Wada, A., Narita, M., Nagasawa, M., Kusaba, T., Kubota, S., Yoshida, T., Johnin, K., Kawauchi, A., Kageyama, S."Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer". Oncology Letters 24.4 (2022): 333.
Chicago
Wada, A., Narita, M., Nagasawa, M., Kusaba, T., Kubota, S., Yoshida, T., Johnin, K., Kawauchi, A., Kageyama, S."Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer". Oncology Letters 24, no. 4 (2022): 333. https://doi.org/10.3892/ol.2022.13453
Copy and paste a formatted citation
x
Spandidos Publications style
Wada A, Narita M, Nagasawa M, Kusaba T, Kubota S, Yoshida T, Johnin K, Kawauchi A and Kageyama S: Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer. Oncol Lett 24: 333, 2022.
APA
Wada, A., Narita, M., Nagasawa, M., Kusaba, T., Kubota, S., Yoshida, T. ... Kageyama, S. (2022). Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer. Oncology Letters, 24, 333. https://doi.org/10.3892/ol.2022.13453
MLA
Wada, A., Narita, M., Nagasawa, M., Kusaba, T., Kubota, S., Yoshida, T., Johnin, K., Kawauchi, A., Kageyama, S."Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer". Oncology Letters 24.4 (2022): 333.
Chicago
Wada, A., Narita, M., Nagasawa, M., Kusaba, T., Kubota, S., Yoshida, T., Johnin, K., Kawauchi, A., Kageyama, S."Androgen receptor axis‑targeted agents are not superior to conventional hormonal therapy for treatment of metastatic prostate cancer". Oncology Letters 24, no. 4 (2022): 333. https://doi.org/10.3892/ol.2022.13453
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