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Case Report Open Access

Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report

  • Authors:
    • Andrea Vucetic
    • Belal Ahmad
    • Terence Tang
  • View Affiliations / Copyright

    Affiliations: Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada, Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada
    Copyright: © Vucetic et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 335
    |
    Published online on: August 9, 2022
       https://doi.org/10.3892/ol.2022.13454
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Abstract

Intracranial recurrence following initial cranial irradiation for extensive‑stage small cell lung cancer (ES‑SCLC) can often be a treatment dilemma given the aggressive nature of the disease, the overall poor prognosis and concerns regarding re‑treatment toxicity. The present report describes the case of a 62‑year‑old man diagnosed with ES‑SCLC and synchronous brain metastases who initially underwent whole brain radiotherapy, chemotherapy and consolidative thoracic radiotherapy. The patient was found to have a solitary intracranial recurrence at both 3.5 and 6 years after his diagnosis. On both occasions, the patient received salvage stereotactic radiation, 30 Gy in 5 fractions, and continues to remain functionally independent. Overall, the present case demonstrates that with the appropriate patient selection, aggressive local salvage of recurrent intracranial ES‑SCLC with stereotactic radiation can yield excellent and durable clinical outcomes.
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1 

Elias AD: Small cell lung cancer: State-of-the-art therapy in 1996. Chest. 112 (Suppl 4):251S–258S. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Jett JR, Schild SE, Kesler KA and Kalemkerian GP: Treatment of small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 143 (Suppl 5):e400S–e419S. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Demedts IK, Vermaelen KY and van Meerbeeck JP: Treatment of extensive-stage small cell lung carcinoma: Current status and future prospects. Eur Respir J. 35:202–215. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Howlader N NA, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ and Cronin KA: SEER cancer statistics review. 5-Year Survival Rates National Cancer Institute; Bethesda: MD1975. 2017

5 

Seute T, Leffers P, ten Velde GP and Twijnstra A: Neurologic disorders in 432 consecutive patients with small cell lung carcinoma. Cancer. 100:801–806. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Slotman B, Faivre-Finn C, Kramer G, Rankin E, Snee M, Hatton M, Postmus P, Collette L, Musat E and Senan S; EORTC Radiation Oncology Group and Lung Cancer Group, : Prophylactic cranial irradiation in extensive small-cell lung cancer. N Engl J Med. 357:664–672. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Tsao MN, Lloyd N, Wong RK, Chow E, Rakovitch E, Laperriere N, Xu W and Sahgal A: Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases. Cochrane Database Syst Rev. 2012:CD0038692012.PubMed/NCBI

8 

Bernhardt D, Adeberg S, Bozorgmehr F, Opfermann N, Hoerner-Rieber J, König L, Kappes J, Thomas M, Herth F, Heußel CP, et al: Outcome and prognostic factors in patients with brain metastases from small-cell lung cancer treated with whole brain radiotherapy. J Neurooncol. 134:205–212. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Suzuki R, Wei X, Allen PK, Welsh JW, Cox JD, Komaki R and Lin SH: Outcomes of re-irradiation for brain recurrence after prophylactic or therapeutic whole-brain irradiation for small cell lung Cancer: A retrospective analysis. Radiat Oncol. 13:2582018. View Article : Google Scholar : PubMed/NCBI

10 

Fairchild A, Guest N, Letcher A, Mazure B, Ghosh S, Gabos Z, Chu KP, Debenham B, Nijjar T, Severin D, et al: Should stereotactic radiosurgery be considered for salvage of intracranial recurrence after prophylactic cranial irradiation or whole brain radiotherapy in small cell lung cancer? A population-based analysis and literature review. J Med Imaging Radiat Sci. 51:75–87.e2. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Arriagada R, Le Chevalier T, Rivière A, Chomy P, Monnet I, Bardet E, Santos-Miranda JA, Péhoux CL, Tarayre M, Benhamou S and Laplanche A: Patterns of failure after prophylactic cranial irradiation in small-cell lung cancer: Analysis of 505 randomized patients. Ann Oncol. 13:748–754. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Ramlov A, Tietze A, Khalil AA and Knap MM: Prophylactic cranial irradiation in patients with small cell lung cancer. A retrospective study of recurrence, survival and morbidity. Lung Cancer. 77:561–566. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Aupérin A, Arriagada R, Pignon JP, Péchoux CL, Gregor A, Stephens RJ, Kristjansen PE, Johnson BE, Ueoka H, Wagner H and Aisner J: Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. New Engl J Med. 341:476–484. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Postmus PE, Haaxma-Reiche H, Gregor A, Groen HJ, Lewinski T, Scolard T, Kirkpatrick A, Curran D, Sahmoud T and Giaccone G: Brain-only metastases of small cell lung cancer; efficacy of whole brain radiotherapy. An EORTC phase II study. Radiother Oncol. 46:29–32. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Bernhardt D, Adeberg S, Bozorgmehr F, Opfermann N, Hörner-Rieber J, König L, Kappes J, Thomas M, Unterberg A, Herth F, et al: Outcome and prognostic factors in single brain metastases from small-cell lung cancer. Strahlenther Onkol. 194:98–106. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Bernhardt D, Bozorgmehr F, Adeberg S, Opfermann N, von Eiff D, Rieber J, Kappes J, Foerster R, König L, Thomas M, et al: Outcome in patients with small cell lung cancer re-irradiated for brain metastases after prior prophylactic cranial irradiation. Lung Cancer. 101:76–81. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Son CH, Jimenez R, Niemierko A, Loeffler JS, Oh KS and Shih HA: Outcomes after whole brain reirradiation in patients with brain metastases. Int J Radiat Oncol Biol Phys. 82:e167–e172. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Sheehan J, Kondziolka D, Flickinger J and Lunsford LD: Radiosurgery for patients with recurrent small cell lung carcinoma metastatic to the brain: Outcomes and prognostic factors. J Neurosurg. 102:247–254. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Wegner RE, Olson AC, Kondziolka D, Niranjan A, Lundsford LD and Flickinger JC: Stereotactic radiosurgery for patients with brain metastases from small cell lung cancer. Int J Radiat Oncol Biol Phys. 81:e21–e27. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Nakazaki K, Higuchi Y, Nagano O and Serizawa T: Efficacy and limitations of salvage gamma knife radiosurgery for brain metastases of small-cell lung cancer after whole-brain radiotherapy. Acta Neurochir (Wien). 155:107–114. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Harris S, Chan MD, Lovato JF, Ellis TL, Tatter SB, Bourland JD, Munley MT, deGuzman AF, Shaw EG, Urbanic JJ and McMullen KP: Gamma knife stereotactic radiosurgery as salvage therapy after failure of whole-brain radiotherapy in patients with small-cell lung cancer. Int J Radiat Oncol Biol Phys. 83:e53–59. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Nakazaki K, Yomo S, Kondoh T, Serizawa T, Kenai H, Kawagishi J, Sato S, Nagano O, Aiyama H, Kawai H, et al: Salvage gamma knife radiosurgery for active brain metastases from small-cell lung cancer after whole-brain radiation therapy: A retrospective multi-institutional study (JLGK1701). J Neurooncol. 147:67–76. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Rava P, Sioshansi S, DiPetrillo T, Cosgrove R, Melhus C, Wu J, Mignano J, Wazer DE and Hepel JT: Local recurrence and survival following stereotactic radiosurgery for brain metastases from small cell lung cancer. Pract Radiat Oncol. 5:e37–e44. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Li XP, Xiao JP, Chen XJ, Jiang XS, Zhang Y and Xu YJ: Fractionated stereotactic radiotherapy for small-cell lung cancer patients with brain metastases. J Cancer Res Ther. 10:597–602. 2014.PubMed/NCBI

25 

Olson AC, Wegner RE, Rwigema JC, Heron DE, Burton SA and Mintz AH: Clinical outcomes of reirradiation of brain metastases from small cell lung cancer with Cyberknife stereotactic radiosurgery. J Cancer Res Ther. 8:411–416. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Blonigen BJ, Steinmetz RD, Levin L, Lamba MA, Warnick RE and Breneman JC: Irradiated volume as a predictor of brain radionecrosis after linear accelerator stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 77:996–1001. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Faramand A, Niranjan A, Kano H, Flickinger J and Lunsford LD: Primary or salvage stereotactic radiosurgery for brain metastatic small cell lung cancer. J Neurooncol. 144:217–225. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Minniti G, D'Angelillo RM, Scaringi C, Trodella LE, Clarke E, Matteucci P, Osti MF, Ramella S, Enrici RM and Trodella L: Fractionated stereotactic radiosurgery for patients with brain metastases. J Neurooncol. 117:295–301. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Vucetic A, Ahmad B and Tang T: Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report. Oncol Lett 24: 335, 2022.
APA
Vucetic, A., Ahmad, B., & Tang, T. (2022). Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report. Oncology Letters, 24, 335. https://doi.org/10.3892/ol.2022.13454
MLA
Vucetic, A., Ahmad, B., Tang, T."Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report". Oncology Letters 24.4 (2022): 335.
Chicago
Vucetic, A., Ahmad, B., Tang, T."Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report". Oncology Letters 24, no. 4 (2022): 335. https://doi.org/10.3892/ol.2022.13454
Copy and paste a formatted citation
x
Spandidos Publications style
Vucetic A, Ahmad B and Tang T: Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report. Oncol Lett 24: 335, 2022.
APA
Vucetic, A., Ahmad, B., & Tang, T. (2022). Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report. Oncology Letters, 24, 335. https://doi.org/10.3892/ol.2022.13454
MLA
Vucetic, A., Ahmad, B., Tang, T."Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report". Oncology Letters 24.4 (2022): 335.
Chicago
Vucetic, A., Ahmad, B., Tang, T."Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report". Oncology Letters 24, no. 4 (2022): 335. https://doi.org/10.3892/ol.2022.13454
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