Long‑term survival in a patient with extensive‑stage small cell lung cancer treated with multiple courses of salvage stereotactic radiation after whole brain radiotherapy: A case report
- Andrea Vucetic
- Belal Ahmad
- Terence Tang
Affiliations: Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada, Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada
- Published online on: August 9, 2022 https://doi.org/10.3892/ol.2022.13454
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Intracranial recurrence following initial cranial irradiation for extensive‑stage small cell lung cancer (ES‑SCLC) can often be a treatment dilemma given the aggressive nature of the disease, the overall poor prognosis and concerns regarding re‑treatment toxicity. The present report describes the case of a 62‑year‑old man diagnosed with ES‑SCLC and synchronous brain metastases who initially underwent whole brain radiotherapy, chemotherapy and consolidative thoracic radiotherapy. The patient was found to have a solitary intracranial recurrence at both 3.5 and 6 years after his diagnosis. On both occasions, the patient received salvage stereotactic radiation, 30 Gy in 5 fractions, and continues to remain functionally independent. Overall, the present case demonstrates that with the appropriate patient selection, aggressive local salvage of recurrent intracranial ES‑SCLC with stereotactic radiation can yield excellent and durable clinical outcomes.