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Article Open Access

tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1

Retraction in: /10.3892/ol.2025.15150
  • Authors:
    • Yang Wang
    • Wenying Xia
    • Fangrong Shen
    • Jinhua Zhou
    • Yanzheng Gu
    • Youguo Chen
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Group Suqian Hospital and The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu 223800, P.R. China, Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 334
    |
    Published online on: August 9, 2022
       https://doi.org/10.3892/ol.2022.13455
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Abstract

A transfer RNA (tRNA)‑derived fragment (tRF) was found to be a new possible biological marker and target in carcinoma therapy. However, the effect exerted by tRFs on cervical carcinoma remains unclear. In the present study, the potential tumor suppressor gene tRF‑Glu49 was identified in cervical carcinoma through tRF and tiRNA microarray investigation. A reverse transcription‑quantitative PCR assay then demonstrated that tRF‑Glu49 was downregulated in the cervical carcinoma tissue. Further clinicopathological analysis proved that tRF‑Glu49 was associated with less aggressive clinical features and improved prognosis. Cell Counting Kit‑8 tests, Transwell and Matrigel tests, and xCELLigence system tests revealed that tRF‑Glu49 inhibited cervical cell proliferation, migration and invasion processes. Mechanistic investigation revealed that tRF‑Glu49 directly regulated the oncogene, fibrinogen‑like protein‑1 (FGL1). In general, according to the result achieved in the present study, tRF‑Glu49 can modulate cervical cell proliferation, migration, and invasion processes through the target process for FGL1, and tRF‑Glu49 is likely to be a possible prognostic biological marker in patients with cervical carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Xia W, Shen F, Zhou J, Gu Y and Chen Y: tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 Retraction in /10.3892/ol.2025.15150. Oncol Lett 24: 334, 2022.
APA
Wang, Y., Xia, W., Shen, F., Zhou, J., Gu, Y., & Chen, Y. (2022). tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 Retraction in /10.3892/ol.2025.15150. Oncology Letters, 24, 334. https://doi.org/10.3892/ol.2022.13455
MLA
Wang, Y., Xia, W., Shen, F., Zhou, J., Gu, Y., Chen, Y."tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 Retraction in /10.3892/ol.2025.15150". Oncology Letters 24.4 (2022): 334.
Chicago
Wang, Y., Xia, W., Shen, F., Zhou, J., Gu, Y., Chen, Y."tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 Retraction in /10.3892/ol.2025.15150". Oncology Letters 24, no. 4 (2022): 334. https://doi.org/10.3892/ol.2022.13455
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Xia W, Shen F, Zhou J, Gu Y and Chen Y: tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 Retraction in /10.3892/ol.2025.15150. Oncol Lett 24: 334, 2022.
APA
Wang, Y., Xia, W., Shen, F., Zhou, J., Gu, Y., & Chen, Y. (2022). tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 Retraction in /10.3892/ol.2025.15150. Oncology Letters, 24, 334. https://doi.org/10.3892/ol.2022.13455
MLA
Wang, Y., Xia, W., Shen, F., Zhou, J., Gu, Y., Chen, Y."tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 Retraction in /10.3892/ol.2025.15150". Oncology Letters 24.4 (2022): 334.
Chicago
Wang, Y., Xia, W., Shen, F., Zhou, J., Gu, Y., Chen, Y."tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1 Retraction in /10.3892/ol.2025.15150". Oncology Letters 24, no. 4 (2022): 334. https://doi.org/10.3892/ol.2022.13455
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