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Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy

  • Authors:
    • Sho Okuda
    • Kenoki Ohuchida
    • Koji Shindo
    • Taiki Moriyama
    • Jun Kawata
    • Koji Tamura
    • Masafumi Sada
    • Kinuko Nagayoshi
    • Yusuke Mizuuchi
    • Naoki Ikenaga
    • Kohei Nakata
    • Yoshinao Oda
    • Masafumi Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan
    Copyright: © Okuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 337
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    Published online on: August 11, 2022
       https://doi.org/10.3892/ol.2022.13457
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Abstract

For stage II and III esophageal squamous cell carcinoma (ESCC), neoadjuvant chemotherapy (NAC) followed by esophagectomy is recommended in the Japanese guidelines for the diagnosis and treatment of esophageal cancer. However, recurrence of ESCC is common regardless of the NAC regimen and surgical method, and NAC demonstrates limited efficacy against recurrence. Therefore, the present study was conducted to identify risk factors of recurrence of ESCC with surgery after NAC. The outcomes of 51 patients who underwent esophagectomy for ESCC after NAC from 2010 to 2017 at Kyushu University Hospital were retrospectively analyzed. A total of 52 patients with ESCC without NAC followed by esophagectomy from 2001 to 2017 were selected for comparison. Among patients who underwent NAC followed by surgery, only lymphatic invasion (LY; hazard ratio, 2.761; 95% CI, 1.86‑6.43, P=0.018) was an independent factor significantly associated with 3‑year recurrence‑free survival in the multivariate analysis. In patients with pathologic lymph node metastasis (pN) and no LY after NAC, there was significantly less recurrence compared with patients with pN and LY (P=0.0085), whereas in patients without LY after NAC, the presence of pN was not significantly associated with recurrence (P=0.2401). There were significantly fewer LY (+) patients in the NAC (+) group (P=0.0158) compared with those in the NAC (‑) group. The presence of LY was an independent risk factor for recurrence of ESCC after esophagectomy following NAC. Overall, adjuvant treatment after surgery may be required in cases with remnant LY after NAC.
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Copy and paste a formatted citation
Spandidos Publications style
Okuda S, Ohuchida K, Shindo K, Moriyama T, Kawata J, Tamura K, Sada M, Nagayoshi K, Mizuuchi Y, Ikenaga N, Ikenaga N, et al: Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy. Oncol Lett 24: 337, 2022.
APA
Okuda, S., Ohuchida, K., Shindo, K., Moriyama, T., Kawata, J., Tamura, K. ... Nakamura, M. (2022). Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy. Oncology Letters, 24, 337. https://doi.org/10.3892/ol.2022.13457
MLA
Okuda, S., Ohuchida, K., Shindo, K., Moriyama, T., Kawata, J., Tamura, K., Sada, M., Nagayoshi, K., Mizuuchi, Y., Ikenaga, N., Nakata, K., Oda, Y., Nakamura, M."Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy". Oncology Letters 24.4 (2022): 337.
Chicago
Okuda, S., Ohuchida, K., Shindo, K., Moriyama, T., Kawata, J., Tamura, K., Sada, M., Nagayoshi, K., Mizuuchi, Y., Ikenaga, N., Nakata, K., Oda, Y., Nakamura, M."Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy". Oncology Letters 24, no. 4 (2022): 337. https://doi.org/10.3892/ol.2022.13457
Copy and paste a formatted citation
x
Spandidos Publications style
Okuda S, Ohuchida K, Shindo K, Moriyama T, Kawata J, Tamura K, Sada M, Nagayoshi K, Mizuuchi Y, Ikenaga N, Ikenaga N, et al: Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy. Oncol Lett 24: 337, 2022.
APA
Okuda, S., Ohuchida, K., Shindo, K., Moriyama, T., Kawata, J., Tamura, K. ... Nakamura, M. (2022). Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy. Oncology Letters, 24, 337. https://doi.org/10.3892/ol.2022.13457
MLA
Okuda, S., Ohuchida, K., Shindo, K., Moriyama, T., Kawata, J., Tamura, K., Sada, M., Nagayoshi, K., Mizuuchi, Y., Ikenaga, N., Nakata, K., Oda, Y., Nakamura, M."Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy". Oncology Letters 24.4 (2022): 337.
Chicago
Okuda, S., Ohuchida, K., Shindo, K., Moriyama, T., Kawata, J., Tamura, K., Sada, M., Nagayoshi, K., Mizuuchi, Y., Ikenaga, N., Nakata, K., Oda, Y., Nakamura, M."Clinical impact of remnant lymphatic invasion on the recurrence of esophageal squamous cell carcinoma after esophagectomy with neoadjuvant chemotherapy". Oncology Letters 24, no. 4 (2022): 337. https://doi.org/10.3892/ol.2022.13457
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