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Case Report Open Access

Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report

  • Authors:
    • Yiying Tao
    • Lei Tang
    • Li Zuo
    • Yue Ma
    • Fengchun Zhang
    • Yingchun Xu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, P.R. China, Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, Jiangsu 215000, P.R. China, Department of Oncology, Fudan University Shanghai Cancer Center, Minhang Branch, Shanghai 201100, P.R. China
    Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 344
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    Published online on: August 17, 2022
       https://doi.org/10.3892/ol.2022.13464
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Abstract

Pancreatic cancer (PC) is a fatal disease with a high mortality rate due to difficulties in early diagnosis and metastasis. Common sites of metastasis from PC include the liver, lung, stomach and kidney. Patients diagnosed at already the metastatic stages on presentation constitute 50‑55% of the cases, with a 5‑year survival rate of 3%. By contrast, secondary ovarian metastases account for 10‑25% of all ovarian malignancies, though an accurate diagnosis remain challenging. The present study reports the rare case of a 42‑year‑old woman with primary hepatic metastasis and secondary ovarian metastasis from PC treated with two lines of immunotherapy, who is also experiencing severe treatment‑associated toxicity. The patient first received combined immunotherapy consisting of camrelizumab (200 mg; day 1; every 3 weeks) and chemotherapy with nab‑paclitaxel (125 mg/m2; days 1 and 8; every 3 weeks) and gemcitabine (1,000 mg/m2; days 1 and 8; every 3 weeks). She then exhibited a partial response following 4 months of treatment. However, 9 months after the initial treatment, the disease progressed with ovarian involvement, which was confirmed by surgery. Second‑line treatment included immunotherapy, targeted therapy and oral chemotherapy (200 mg sintilimab on day 1; 50 mg tegafur from days 1‑14, twice daily; and 8 mg anlotinib from days 1‑14, every 3 weeks). The progression‑free survival time from this second‑line treatment was 6 months. Immunotherapy was permanently aborted due to severe intestinal inflammation, where four lines of combined treatments were recommended. The patient remains on treatment with a good quality of life in July 2022, and a current overall survival time of >24 months. In conclusion, the diagnosis of metastatic PC leads to a poor prognosis, but ovarian metastasis from PC is rare. Furthermore, the combination of immunotherapy with chemotherapy or antiangiogenic inhibitors shows promise as a treatment strategy for advanced stages of PC.
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Copy and paste a formatted citation
Spandidos Publications style
Tao Y, Tang L, Zuo L, Ma Y, Zhang F and Xu Y: Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report. Oncol Lett 24: 344, 2022.
APA
Tao, Y., Tang, L., Zuo, L., Ma, Y., Zhang, F., & Xu, Y. (2022). Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report. Oncology Letters, 24, 344. https://doi.org/10.3892/ol.2022.13464
MLA
Tao, Y., Tang, L., Zuo, L., Ma, Y., Zhang, F., Xu, Y."Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report". Oncology Letters 24.4 (2022): 344.
Chicago
Tao, Y., Tang, L., Zuo, L., Ma, Y., Zhang, F., Xu, Y."Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report". Oncology Letters 24, no. 4 (2022): 344. https://doi.org/10.3892/ol.2022.13464
Copy and paste a formatted citation
x
Spandidos Publications style
Tao Y, Tang L, Zuo L, Ma Y, Zhang F and Xu Y: Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report. Oncol Lett 24: 344, 2022.
APA
Tao, Y., Tang, L., Zuo, L., Ma, Y., Zhang, F., & Xu, Y. (2022). Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report. Oncology Letters, 24, 344. https://doi.org/10.3892/ol.2022.13464
MLA
Tao, Y., Tang, L., Zuo, L., Ma, Y., Zhang, F., Xu, Y."Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report". Oncology Letters 24.4 (2022): 344.
Chicago
Tao, Y., Tang, L., Zuo, L., Ma, Y., Zhang, F., Xu, Y."Metastatic ovarian tumor from pancreatic cancer treated with combined immunotherapy: A case report". Oncology Letters 24, no. 4 (2022): 344. https://doi.org/10.3892/ol.2022.13464
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