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Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer:
Results of a retrospective cohort study

  • Authors:
    • Katharina Anic
    • Mona Wanda Schmidt
    • Annika Droste
    • Roxana Schwab
    • Marcus Schmidt
    • Slavomir Krajnak
    • Miriam Renz
    • Erik Kristoffer Hartmann
    • Roland Hardt
    • Annette Hasenburg
    • Marco Johannes Battista
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, University Medical Center of The Johannes Gutenberg University Mainz, D‑55131 Mainz, Germany, Department of Anesthesiology, University Medical Center of The Johannes Gutenberg University Mainz, D‑55131 Mainz, Germany, Department of Geriatric Medicine, University Medical Center of The Johannes Gutenberg University Mainz, D‑55131 Mainz, Germany
    Copyright: © Anic et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 361
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    Published online on: August 26, 2022
       https://doi.org/10.3892/ol.2022.13481
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Abstract

Epidural analgesia could influence the postoperative oncologic outcomes in patients with specific types of non‑metastatic solid neoplasms. The present study aimed to investigate the impact of anesthetic technique on survival in elderly patients with ovarian cancer (OC). The records of all women with OC older than 60 years of age undergoing tumor debulking surgery at the University Medical Center of the Johannes Gutenberg University Mainz (Mainz, Germany) between January 2008 and December 2019 were obtained. The study cohort was divided into two groups based on the use of perioperative epidural anesthesia or not. First, Kaplan‑Meier analysis was performed to analyze the prognostic influence of anesthetic technique on survival. Second, multivariate Cox proportional hazards model was adjusted for multiple conventional prognostic factors concerning three main categories: i) Current clinical‑pathological tumor characteristics; ii) anesthesiologic parameters, including mean age, American Society of Anesthesiologists Performance Status and preexisting comorbidities summarized in the Charlson Comorbidity Index; and iii) oncological and surgical parameters such as oncological radicality and Surgical complexity Score. A total of 110 patients were included in the study and 71 (64.5%) of them received epidural analgesia. The median survival time was 26.0 months from primary debulking surgery and no significant differences in progression‑free (PFS) and overall survival (OS) were noted between the ‘Epidural’ and ‘non‑Epidural’ cohorts. After adjustment for the selected risk factors from the three categories, the effects of epidural analgesia on PFS and OS remained non‑significant [PFS: hazard ratio (HR), 1.26; 95% CI, 0.66‑2.39; and OS: HR, 0.79; 95% CI, 0.45‑1.40]. The present results did not support the independent association between epidural‑supplemented anesthesia and improved PFS or OS in elderly patients with standardized ovarian cancer debulking surgery.
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Copy and paste a formatted citation
Spandidos Publications style
Anic K, Schmidt MW, Droste A, Schwab R, Schmidt M, Krajnak S, Renz M, Hartmann EK, Hardt R, Hasenburg A, Hasenburg A, et al: Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer: <br />Results of a retrospective cohort study. Oncol Lett 24: 361, 2022.
APA
Anic, K., Schmidt, M.W., Droste, A., Schwab, R., Schmidt, M., Krajnak, S. ... Battista, M.J. (2022). Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer: <br />Results of a retrospective cohort study. Oncology Letters, 24, 361. https://doi.org/10.3892/ol.2022.13481
MLA
Anic, K., Schmidt, M. W., Droste, A., Schwab, R., Schmidt, M., Krajnak, S., Renz, M., Hartmann, E. K., Hardt, R., Hasenburg, A., Battista, M. J."Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer: <br />Results of a retrospective cohort study". Oncology Letters 24.4 (2022): 361.
Chicago
Anic, K., Schmidt, M. W., Droste, A., Schwab, R., Schmidt, M., Krajnak, S., Renz, M., Hartmann, E. K., Hardt, R., Hasenburg, A., Battista, M. J."Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer: <br />Results of a retrospective cohort study". Oncology Letters 24, no. 4 (2022): 361. https://doi.org/10.3892/ol.2022.13481
Copy and paste a formatted citation
x
Spandidos Publications style
Anic K, Schmidt MW, Droste A, Schwab R, Schmidt M, Krajnak S, Renz M, Hartmann EK, Hardt R, Hasenburg A, Hasenburg A, et al: Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer: <br />Results of a retrospective cohort study. Oncol Lett 24: 361, 2022.
APA
Anic, K., Schmidt, M.W., Droste, A., Schwab, R., Schmidt, M., Krajnak, S. ... Battista, M.J. (2022). Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer: <br />Results of a retrospective cohort study. Oncology Letters, 24, 361. https://doi.org/10.3892/ol.2022.13481
MLA
Anic, K., Schmidt, M. W., Droste, A., Schwab, R., Schmidt, M., Krajnak, S., Renz, M., Hartmann, E. K., Hardt, R., Hasenburg, A., Battista, M. J."Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer: <br />Results of a retrospective cohort study". Oncology Letters 24.4 (2022): 361.
Chicago
Anic, K., Schmidt, M. W., Droste, A., Schwab, R., Schmidt, M., Krajnak, S., Renz, M., Hartmann, E. K., Hardt, R., Hasenburg, A., Battista, M. J."Influence of anesthetic technique on survival after tumor debulking surgery of elderly patients with ovarian cancer: <br />Results of a retrospective cohort study". Oncology Letters 24, no. 4 (2022): 361. https://doi.org/10.3892/ol.2022.13481
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