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Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma

  • Authors:
    • Byeong-Joo Noh
    • Gun Moo Choi
    • Hyuk Jai Jang
    • Chung Hyeun Ma
    • Ho-Suk Oh
    • Moonho Kim
    • Dae-Woon Eom
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Gangwon‑do 25440, Republic of Korea, Department of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Gangwon‑do 25440, Republic of Korea, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Gangwon‑do 25440, Republic of Korea
    Copyright: © Noh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 373
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    Published online on: September 5, 2022
       https://doi.org/10.3892/ol.2022.13493
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Abstract

Indoleamine 2, 3‑dioxygenase 1 (IDO1) is an immunomodulatory enzyme that catalyzes the degradation of tryptophan to kynurenine and induces immune tolerance in tumor cells. The effects of IDO1 on extrahepatic bile duct carcinoma (EHBDC) are poorly understood. Therefore, the present study aimed to investigate the expression and prognostic significance of IDO1 in EHBDC. An immunohistochemical microarray analysis of IDO1 expression was performed for 76 surgically resected cases of EHBDC. CD8+ tumor infiltrating lymphocytes (TILs) were also investigated through a combination analysis with IDO1 expression. IDO1 was highly expressed in 25 of 76 (32.9%) cases. High expression of IDO1 was associated with decreased numbers of CD8+ TILs (P=0.008), a higher pN category (P=0.007), an advanced overall stage (P=0.001) and frequent recurrence (P=0.018). When IDO1 expression was further stratified with CD8+ TIL state, the IDO1high/CD8low subgroup was decreased in terms of overall survival (P=0.025) and disease‑free survival (P=0.015) compared with IDO1high/CD8high, IDO1low/CD8high and IDO1low/CD8low subgroups. High IDO1 expression was associated with a decreased number of CD8+ TILs and associated with a poor prognosis. As IDO1 may be a new target of immunotherapy applications, IDO1/CD8+ TIL subgrouping can be a useful prognostic and predictive tool in patients with EHBDC.
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Copy and paste a formatted citation
Spandidos Publications style
Noh B, Choi GM, Jang HJ, Ma CH, Oh H, Kim M and Eom D: Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma. Oncol Lett 24: 373, 2022.
APA
Noh, B., Choi, G.M., Jang, H.J., Ma, C.H., Oh, H., Kim, M., & Eom, D. (2022). Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma. Oncology Letters, 24, 373. https://doi.org/10.3892/ol.2022.13493
MLA
Noh, B., Choi, G. M., Jang, H. J., Ma, C. H., Oh, H., Kim, M., Eom, D."Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma". Oncology Letters 24.4 (2022): 373.
Chicago
Noh, B., Choi, G. M., Jang, H. J., Ma, C. H., Oh, H., Kim, M., Eom, D."Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma". Oncology Letters 24, no. 4 (2022): 373. https://doi.org/10.3892/ol.2022.13493
Copy and paste a formatted citation
x
Spandidos Publications style
Noh B, Choi GM, Jang HJ, Ma CH, Oh H, Kim M and Eom D: Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma. Oncol Lett 24: 373, 2022.
APA
Noh, B., Choi, G.M., Jang, H.J., Ma, C.H., Oh, H., Kim, M., & Eom, D. (2022). Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma. Oncology Letters, 24, 373. https://doi.org/10.3892/ol.2022.13493
MLA
Noh, B., Choi, G. M., Jang, H. J., Ma, C. H., Oh, H., Kim, M., Eom, D."Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma". Oncology Letters 24.4 (2022): 373.
Chicago
Noh, B., Choi, G. M., Jang, H. J., Ma, C. H., Oh, H., Kim, M., Eom, D."Prognostic implications of immune classification using IDO1 expression in extrahepatic bile duct carcinoma". Oncology Letters 24, no. 4 (2022): 373. https://doi.org/10.3892/ol.2022.13493
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