Open Access

Study on the method to avoid infusion‑site adverse events following chemotherapeutic treatment with epirubicin and fosaprepitant using immortalized human umbilical vein endothelial cells

  • Authors:
    • Miho Yamasaki
    • Keisuke Oda
    • Takashi Ichinose
    • Marie Mizuguchi
    • Shoko Tominaga
    • Kei Omoda
    • Nobuhiro Mori
    • Yorinobu Maeda
    • Toshihiro Nishida
    • Teruo Murakami
  • View Affiliations

  • Published online on: September 16, 2022     https://doi.org/10.3892/ol.2022.13506
  • Article Number: 386
  • Copyright: © Yamasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The combination of intravenous Proemend® containing fosaprepitant meglumine, a prodrug for fosaprepitant (FAP), and Tween 80 and chemotherapy with anthracyclines, such as epirubicin (EPI), can cause infusion‑site adverse events in clinical practice. In immortalized human umbilical vein endothelial (HUEhT‑1) cells, the cytotoxic effects of FAP, EPI, diluted Proemend with culture medium and Tween 80 alone, and a combination of FAP and EPI, were evaluated using the WST‑1 cell viability assay. FAP, EPI and diluted Proemend exhibited cytotoxicity in a concentration‑dependent manner and marked synergic cytotoxicity was observed between FAP and EPI. The washing of the cell surface following incubation with diluted Proemend containing FAP and Tween‑80 eliminated the synergic cytotoxicity of EPI applied thereafter. These results indicated that washing of the infusion‑site vascular tissue following intravenous Proemend administration via intravenous tube flushing with an efficient amount of saline may reduce the infusion‑site adverse events, which are caused by the combined use of FAP and EPI.
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November-2022
Volume 24 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yamasaki M, Oda K, Ichinose T, Mizuguchi M, Tominaga S, Omoda K, Mori N, Maeda Y, Nishida T, Murakami T, Murakami T, et al: Study on the method to avoid infusion‑site adverse events following chemotherapeutic treatment with epirubicin and fosaprepitant using immortalized human umbilical vein endothelial cells. Oncol Lett 24: 386, 2022
APA
Yamasaki, M., Oda, K., Ichinose, T., Mizuguchi, M., Tominaga, S., Omoda, K. ... Murakami, T. (2022). Study on the method to avoid infusion‑site adverse events following chemotherapeutic treatment with epirubicin and fosaprepitant using immortalized human umbilical vein endothelial cells. Oncology Letters, 24, 386. https://doi.org/10.3892/ol.2022.13506
MLA
Yamasaki, M., Oda, K., Ichinose, T., Mizuguchi, M., Tominaga, S., Omoda, K., Mori, N., Maeda, Y., Nishida, T., Murakami, T."Study on the method to avoid infusion‑site adverse events following chemotherapeutic treatment with epirubicin and fosaprepitant using immortalized human umbilical vein endothelial cells". Oncology Letters 24.5 (2022): 386.
Chicago
Yamasaki, M., Oda, K., Ichinose, T., Mizuguchi, M., Tominaga, S., Omoda, K., Mori, N., Maeda, Y., Nishida, T., Murakami, T."Study on the method to avoid infusion‑site adverse events following chemotherapeutic treatment with epirubicin and fosaprepitant using immortalized human umbilical vein endothelial cells". Oncology Letters 24, no. 5 (2022): 386. https://doi.org/10.3892/ol.2022.13506