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Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer

  • Authors:
    • Jia Xiang
    • Mengyao Ding
    • Jixing Lin
    • Tianhui Xue
    • Qianwen Ye
    • Bing Yan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572000, P.R. China, Department of Otolaryngology Head and Neck Surgery, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572000, P.R. China, Department of Thoracic Surgery, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572000, P.R. China
    Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 416
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    Published online on: September 29, 2022
       https://doi.org/10.3892/ol.2022.13536
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Abstract

Both carcinoembryonic antigen (CEA) level and body mass index (BMI) are traditional prognostic markers in colorectal cancer (CRC); however, to the best of our knowledge, the value of the CEA to BMI ratio (CBR) has never been addressed. In the present study, 191 patients with CRC treated using radical resection were retrospectively included, and the significance of the CBR in predicting disease‑free survival (DFS) or overall survival (OS) rates was calculated. The prognostic efficacy of the CBR in predicting OS was compared with individual CEA and BMI values. The survival differences of the subgroups were calculated by Kaplan‑Meier analysis, and corresponding risk factors were then estimated by a Cox proportional hazards model. As a result, 29.84% (57/191) of the patients were assigned to the high CBR group (cut‑off, ≥0.28); the CBR had a sensitivity of 56.50 and 68.90%, and a specificity of 80.60 and 80.10% for DFS and OS, respectively. Patients with a high CBR more commonly underwent laparotomy and exhibited advanced T stages, the presence of tumor deposits and advanced Tumor‑Node‑Metastasis stages (stage II or III). The CBR was more efficient than the CEA or BMI alone in predicting OS. In addition, patients with a high CBR presented with a significantly worse outcome than patients with a low CBR. Finally, the CBR was an independent risk factor for both DFS and OS. In conclusion, the CBR was a more robust prognostic factor in CRC, and patients with a relatively high CBR exhibited poorer survival.
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Copy and paste a formatted citation
Spandidos Publications style
Xiang J, Ding M, Lin J, Xue T, Ye Q and Yan B: Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer. Oncol Lett 24: 416, 2022.
APA
Xiang, J., Ding, M., Lin, J., Xue, T., Ye, Q., & Yan, B. (2022). Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer. Oncology Letters, 24, 416. https://doi.org/10.3892/ol.2022.13536
MLA
Xiang, J., Ding, M., Lin, J., Xue, T., Ye, Q., Yan, B."Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer". Oncology Letters 24.5 (2022): 416.
Chicago
Xiang, J., Ding, M., Lin, J., Xue, T., Ye, Q., Yan, B."Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer". Oncology Letters 24, no. 5 (2022): 416. https://doi.org/10.3892/ol.2022.13536
Copy and paste a formatted citation
x
Spandidos Publications style
Xiang J, Ding M, Lin J, Xue T, Ye Q and Yan B: Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer. Oncol Lett 24: 416, 2022.
APA
Xiang, J., Ding, M., Lin, J., Xue, T., Ye, Q., & Yan, B. (2022). Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer. Oncology Letters, 24, 416. https://doi.org/10.3892/ol.2022.13536
MLA
Xiang, J., Ding, M., Lin, J., Xue, T., Ye, Q., Yan, B."Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer". Oncology Letters 24.5 (2022): 416.
Chicago
Xiang, J., Ding, M., Lin, J., Xue, T., Ye, Q., Yan, B."Preoperative carcinoembryonic antigen to body mass index ratio contributes to prognosis prediction in colorectal cancer". Oncology Letters 24, no. 5 (2022): 416. https://doi.org/10.3892/ol.2022.13536
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