Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2022 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma

  • Authors:
    • Baasansuren Selenge
    • Shinichiro Yamada
    • Yuji Morine
    • Tetsuya Ikemoto
    • Yu Saito
    • Chie Takasu
    • Hiroki Teraoku
    • Mitsuo Shimada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokushima University, Tokushima, Tokushima 770‑8503, Japan
    Copyright: © Selenge et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 418
    |
    Published online on: September 30, 2022
       https://doi.org/10.3892/ol.2022.13538
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the impact of L‑type amino acid transporter 3 (LAT3) expression on the prognosis of hepatocellular carcinoma (HCC). A total of 135 patients who had undergone initial hepatic resection for HCC at Tokushima University Hospital (Tokushima, Japan) were enrolled in the present study. Immunohistochemical analysis of LAT3 and phosphorylated AKT (p‑AKT) was performed using resected specimens. Clinicopathological factors, including prognosis, were compared between the LAT3‑high and ‑low expression groups. The results demonstrated that the LAT3‑high group showed significantly higher protein induced by vitamin K absence‑II levels (P=0.01) compared with the LAT3‑low group. The LAT3‑high group showed significantly worse prognosis compared with the LAT3‑low group regarding cancer‑specific survival and disease‑free survival (P<0.05). Multivariate analysis revealed that high LAT3 expression and multiple tumors were independent prognostic factors for cancer‑specific survival. Furthermore, the rate of p‑AKT‑positive cases was higher in the LAT3‑high group than in the LAT3‑low group. Overall, these findings suggested that LAT3 expression was associated with poor prognosis of HCC and high p‑AKT expression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Lan T, Yuan K, Yan X, Xu L, Liao H, Hao X, Wang J, Liu H, Chen X, Xie K, et al: LncRNA SNHG10 facilitates hepatocarcinogenesis and metastasis by modulating its homolog SCARNA13 via a positive feedback loop. Cancer Res. 79:3220–3234. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Wang Q and Holst J: L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 5:1281–1294. 2015.PubMed/NCBI

4 

Kanai Y: Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics. Pharmacol Ther. 230:1079642022. View Article : Google Scholar : PubMed/NCBI

5 

Kaira K, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Oriuchi N, Kanai Y, Endo M, Kondo H, et al: Relationship between LAT1 expression and response to platinum-based chemotherapy in non-small cell lung cancer patients with postoperative recurrence. Anticancer Res. 31:3775–3782. 2011.PubMed/NCBI

6 

Zhao Y, Zhang J, Wang S, Jiang Q and Xu K: Identification and validation of a nine-gene amino acid metabolism-related risk signature in HCC. Front Cell Dev Biol. 9:7317902021. View Article : Google Scholar : PubMed/NCBI

7 

Wang Q, Bailey CG, Ng C, Tiffen J, Thoeng A, Minhas V, Lehman ML, Hendy SC, Buchanan G, Nelson CC, et al: Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression. Cancer Res. 71:7525–7536. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Wang Q, Tiffen J, Bailey CG, Lehman ML, Ritchie W, Fazli L, Metierre C, Feng YJ, Li E, Gleave M, et al: Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development. J Natl Cancer Inst. 105:1463–1473. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Wu P, Liu T and Hu Y: PI3K inhibitors for cancer therapy: What has been achieved so far? Curr Med Chem. 16:916–930. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Engelman JA: Targeting PI3K signalling in cancer: Opportunities, challenges and limitations. Nat Rev Cancer. 9:550–562. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Shin E, Choi CM, Kim HR, Jang SJ and Park YS: Immunohistochemical characterization of the mTOR pathway in stage-I non-small-cell lung carcinoma. Lung Cancer. 89:13–18. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Zhang BK, Moran AM, Bailey CG, Rasko JE, Holst J and Wang Q: EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer. Cell Commun Signal. 17:832019. View Article : Google Scholar : PubMed/NCBI

13 

Liver Cancer Study group of Japan, . The general rules for the clinical and pathological study of primary liver cancer. 3rd English edition. Tokyo: Kanehara & Co., Ltd; 2010

14 

Ishikawa D, Shimada M, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Arakawa Y, Kanamoto M, Iwahashi S, Saito Y, et al: Effect of Twist and Bmi1 on intraductal papillary mucinous neoplasm of the pancreas. J Gastroenterol Hepatol. 29:2032–2037. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Namikawa M, Kakizaki S, Kaira K, Tojima H, Yamazaki Y, Horiguchi N, Sato K, Oriuchi N, Tominaga H, Sunose Y, et al: Expression of amino acid transporters (LAT1, ASCT2 and xCT) as clinical significance in hepatocellular carcinoma. Hepatol Res. 45:1014–1022. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Schmitz KJ, Wohlschlaeger J, Lang H, Sotiropoulos GC, Malago M, Steveling K, Reis H, Cicinnati VR, Schmid KW and Baba HA: Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol. 48:83–90. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Rii J, Sakamoto S, Sugiura M, Kanesaka M, Fujimoto A, Yamada Y, Maimaiti M, Ando K, Wakai K, Xu M, et al: Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor. Cancer Sci. 112:3871–3883. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Xu SM, Tang K, Meng L and Tang Y: Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells. J Huazhong Univ Sci Technolog Med Sci. 33:632–635. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Ritchie JW and Taylor PM: Tryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells. Amino Acids. 38:1361–1367. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Zhang S, Chen X, Huang Z, Chen D, Yu B, Chen H, Luo J, He J, Zheng P and Yu J: Leucine promotes differentiation of porcine myoblasts through the protein kinase B (Akt)/Forkhead box O1 signalling pathway. Br J Nutr. 119:727–733. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Nanashima A, Morino S, Yamaguchi H, Tanaka K, Shibasaki S, Tsuji T, Hidaka S, Sawai T, Yasutake T and Nakagoe T: Modified CLIP using PIVKA-II for evaluating prognosis after hepatectomy for hepatocellular carcinoma. Eur J Surg Oncol. 29:735–742. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Okano N, Naruge D, Kawai K, Kobayashi T, Nagashima F, Endou H and Furuse J: First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors. Invest New Drugs. 38:1495–1506. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Wang Q, Grkovic T, Font J, Bonham S, Pouwer RH, Bailey CG, Moran AM, Ryan RM, Rasko JE, Jormakka M, et al: Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth. ACS Chem Biol. 9:1369–1376. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Selenge B, Yamada S, Morine Y, Ikemoto T, Saito Y, Takasu C, Teraoku H and Shimada M: Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma. Oncol Lett 24: 418, 2022.
APA
Selenge, B., Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Takasu, C. ... Shimada, M. (2022). Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma. Oncology Letters, 24, 418. https://doi.org/10.3892/ol.2022.13538
MLA
Selenge, B., Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Takasu, C., Teraoku, H., Shimada, M."Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma". Oncology Letters 24.5 (2022): 418.
Chicago
Selenge, B., Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Takasu, C., Teraoku, H., Shimada, M."Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma". Oncology Letters 24, no. 5 (2022): 418. https://doi.org/10.3892/ol.2022.13538
Copy and paste a formatted citation
x
Spandidos Publications style
Selenge B, Yamada S, Morine Y, Ikemoto T, Saito Y, Takasu C, Teraoku H and Shimada M: Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma. Oncol Lett 24: 418, 2022.
APA
Selenge, B., Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Takasu, C. ... Shimada, M. (2022). Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma. Oncology Letters, 24, 418. https://doi.org/10.3892/ol.2022.13538
MLA
Selenge, B., Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Takasu, C., Teraoku, H., Shimada, M."Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma". Oncology Letters 24.5 (2022): 418.
Chicago
Selenge, B., Yamada, S., Morine, Y., Ikemoto, T., Saito, Y., Takasu, C., Teraoku, H., Shimada, M."Impact of L‑type amino acid transporter 3 on the prognosis of hepatocellular carcinoma". Oncology Letters 24, no. 5 (2022): 418. https://doi.org/10.3892/ol.2022.13538
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team