Open Access

FLASH radiotherapy: A promising new method for radiotherapy (Review)

  • Authors:
    • Yinghao Lv
    • Yue Lv
    • Zhen Wang
    • Tian Lan
    • Xuping Feng
    • Hao Chen
    • Jiang Zhu
    • Xiao Ma
    • Jinpeng Du
    • Guimin Hou
    • Wenwei Liao
    • Kefei Yuan
    • Hong Wu
  • View Affiliations

  • Published online on: October 5, 2022     https://doi.org/10.3892/ol.2022.13539
  • Article Number: 419
  • Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Among the treatments for malignant tumors, radiotherapy is of great significance both as a main treatment and as an adjuvant treatment. Radiation therapy damages cancer cells with ionizing radiation, leading to their death. However, radiation‑induced toxicity limits the dose delivered to the tumor, thereby constraining the control effect of radiotherapy on tumor growth. In addition, the delayed toxicity caused by radiotherapy significantly harms the physical and mental health of patients. FLASH‑RT, an emerging class of radiotherapy, causes a phenomenon known as the ‘FLASH effect’, which delivers radiotherapy at an ultra‑high dose rate with lower toxicity to normal tissue than conventional radiotherapy to achieve local tumor control. Although its mechanism remains to be fully elucidated, this modality constitutes a potential new approach to treating malignant tumors. In the present review, the current research progress of FLASH‑RT and its various particular effects are described, including the status of research on FLASH‑RT and its influencing factors. The hypothetic mechanism of action of FLASH‑RT is also summarized, providing insight into future tumor treatments.
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December-2022
Volume 24 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Lv Y, Lv Y, Wang Z, Lan T, Feng X, Chen H, Zhu J, Ma X, Du J, Hou G, Hou G, et al: FLASH radiotherapy: A promising new method for radiotherapy (Review). Oncol Lett 24: 419, 2022
APA
Lv, Y., Lv, Y., Wang, Z., Lan, T., Feng, X., Chen, H. ... Wu, H. (2022). FLASH radiotherapy: A promising new method for radiotherapy (Review). Oncology Letters, 24, 419. https://doi.org/10.3892/ol.2022.13539
MLA
Lv, Y., Lv, Y., Wang, Z., Lan, T., Feng, X., Chen, H., Zhu, J., Ma, X., Du, J., Hou, G., Liao, W., Yuan, K., Wu, H."FLASH radiotherapy: A promising new method for radiotherapy (Review)". Oncology Letters 24.6 (2022): 419.
Chicago
Lv, Y., Lv, Y., Wang, Z., Lan, T., Feng, X., Chen, H., Zhu, J., Ma, X., Du, J., Hou, G., Liao, W., Yuan, K., Wu, H."FLASH radiotherapy: A promising new method for radiotherapy (Review)". Oncology Letters 24, no. 6 (2022): 419. https://doi.org/10.3892/ol.2022.13539