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Article

Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis

  • Authors:
    • Jae-Won Hyun
    • Yeseul Kim
    • Ki Hoon Kim
    • Su-Hyun Kim
    • Eun Young Park
    • Ji-Hye Youn
    • Heon Yoo
    • Ho-Shin Gwak
    • Ho Jin Kim
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Gyeonggi 10408, Republic of Korea, Division of Clinical Research, Research Institute and Hospital of National Cancer Center, Goyang, Gyeonggi 10408, Republic of Korea, Biostatistics Collaboration Team, Research Institute and Hospital of National Cancer Center, Goyang, Gyeonggi 10408, Republic of Korea, Department of Neurosurgery, Research Institute and Hospital of National Cancer Center, Goyang, Gyeonggi 10408, Republic of Korea
  • Article Number: 428
    |
    Published online on: October 19, 2022
       https://doi.org/10.3892/ol.2022.13548
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Abstract

The present study aimed to evaluate whether the cerebrospinal fluid (CSF) neurofilament light chain (NfL) is a potential prognostic marker for patients with leptomeningeal metastasis (LM). NfL levels were measured in CSF using a single‑molecule array assay. A total of 42 patients with LM who were treated with ventriculo‑lumbar perfusion (VLP) chemotherapy and had available stored CSF samples from the lumbar subarachnoid space before VLP chemotherapy were included in the present study, in order to investigate the prognostic value of CSF NfL. The median CSF NfL level in patients with LM was 8.15 ng/ml; 30% of patients who had died at the time of analysis had CSF NfL levels higher than the calculated overall prognostic cut‑off value (11 ng/ml). The median overall survival after initiation of VLP chemotherapy was significantly longer in patients with LM and low CSF NfL levels compared with in patients with LM and high CSF NfL levels (P<0.001). The statistical significance remained after adjusting for other known prognostic factors and in a subgroup analysis according to age. In conclusion, CSF NfL could be considered a putative prognostic marker in patients with LM treated with VLP chemotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Hyun J, Kim Y, Kim KH, Kim S, Park EY, Youn J, Yoo H, Gwak H and Kim HJ: Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis. Oncol Lett 24: 428, 2022.
APA
Hyun, J., Kim, Y., Kim, K.H., Kim, S., Park, E.Y., Youn, J. ... Kim, H.J. (2022). Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis. Oncology Letters, 24, 428. https://doi.org/10.3892/ol.2022.13548
MLA
Hyun, J., Kim, Y., Kim, K. H., Kim, S., Park, E. Y., Youn, J., Yoo, H., Gwak, H., Kim, H. J."Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis". Oncology Letters 24.6 (2022): 428.
Chicago
Hyun, J., Kim, Y., Kim, K. H., Kim, S., Park, E. Y., Youn, J., Yoo, H., Gwak, H., Kim, H. J."Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis". Oncology Letters 24, no. 6 (2022): 428. https://doi.org/10.3892/ol.2022.13548
Copy and paste a formatted citation
x
Spandidos Publications style
Hyun J, Kim Y, Kim KH, Kim S, Park EY, Youn J, Yoo H, Gwak H and Kim HJ: Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis. Oncol Lett 24: 428, 2022.
APA
Hyun, J., Kim, Y., Kim, K.H., Kim, S., Park, E.Y., Youn, J. ... Kim, H.J. (2022). Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis. Oncology Letters, 24, 428. https://doi.org/10.3892/ol.2022.13548
MLA
Hyun, J., Kim, Y., Kim, K. H., Kim, S., Park, E. Y., Youn, J., Yoo, H., Gwak, H., Kim, H. J."Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis". Oncology Letters 24.6 (2022): 428.
Chicago
Hyun, J., Kim, Y., Kim, K. H., Kim, S., Park, E. Y., Youn, J., Yoo, H., Gwak, H., Kim, H. J."Cerebrospinal fluid neurofilament light chain as a potential prognostic biomarker for leptomeningeal metastasis". Oncology Letters 24, no. 6 (2022): 428. https://doi.org/10.3892/ol.2022.13548
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