Open Access

EBV‑positive large‑cell and small‑cell neuroendocrine carcinoma of the nasopharynx: A case report and review of the literature

  • Authors:
    • Zhen Su
    • Hao Wen Yan
    • Guo Rong Zou
  • View Affiliations

  • Published online on: November 7, 2022     https://doi.org/10.3892/ol.2022.13584
  • Article Number: 464
  • Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Neuroendocrine carcinoma (NEC) of the nasopharynx is rare and its clinical and pathologic characteristics have remained to be fully elucidated. The present study reported on a case of Epstein‑Barr virus (EBV)‑positive NEC of the nasopharynx that exhibited features of large‑cell NEC and small‑cell NEC, as confirmed by immunohistochemical staining. The patient received three cycles of induction chemotherapy (with docetaxel‑cisplatin) that was followed by concurrent chemoradiotherapy (a total of 70 Gy delivered in 33 fractions). Remission of the tumor was achieved and no recurrence or metastasis was detected 6 months after treatment. This is the first report of a patient with EBV‑positive large‑cell and small‑cell NEC of the nasopharynx. The patient achieved good complete remission. Based on the features of this case and a literature review, it was concluded that immunohistochemical staining is important for the differential diagnosis of NEC. Furthermore, there is currently no standard treatment and thus, further clinical information on similar cases is required to optimize treatment outcomes.
View Figures
View References

Related Articles

Journal Cover

December-2022
Volume 24 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Su Z, Yan HW and Zou GR: EBV‑positive large‑cell and small‑cell neuroendocrine carcinoma of the nasopharynx: A case report and review of the literature. Oncol Lett 24: 464, 2022
APA
Su, Z., Yan, H.W., & Zou, G.R. (2022). EBV‑positive large‑cell and small‑cell neuroendocrine carcinoma of the nasopharynx: A case report and review of the literature. Oncology Letters, 24, 464. https://doi.org/10.3892/ol.2022.13584
MLA
Su, Z., Yan, H. W., Zou, G. R."EBV‑positive large‑cell and small‑cell neuroendocrine carcinoma of the nasopharynx: A case report and review of the literature". Oncology Letters 24.6 (2022): 464.
Chicago
Su, Z., Yan, H. W., Zou, G. R."EBV‑positive large‑cell and small‑cell neuroendocrine carcinoma of the nasopharynx: A case report and review of the literature". Oncology Letters 24, no. 6 (2022): 464. https://doi.org/10.3892/ol.2022.13584