Bleomycin‑based electrochemotherapy for the treatment of a Buschke‑Löwenstein tumor (perianal giant condyloma) in an HIV‑positive kidney transplant recipient: A case report

Russano,Francesco; Russo,Irene; Del Fiore,Paolo; Di Prata,Claudia; Mocellin,Simone; Alaibac,Mauro

doi:10.3892/ol.2022.13586

December-2022 Volume 24 Issue 6

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December-2022 Volume 24 Issue 6

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Case Report Open Access

Bleomycin‑based electrochemotherapy for the treatment of a Buschke‑Löwenstein tumor (perianal giant condyloma) in an HIV‑positive kidney transplant recipient: A case report

Authors:
- Francesco Russano
- Irene Russo
- Paolo Del Fiore
- Claudia Di Prata
- Simone Mocellin
- Mauro Alaibac
View Affiliations / Copyright

Affiliations: Soft‑Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV‑IRCCS, I‑35128 Padua, Italy, Department of Medicine, Division of Dermatology, University of Padua, I‑35128 Padua, Italy

Copyright: © Russano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 466
|
Published online on: November 7, 2022

https://doi.org/10.3892/ol.2022.13586
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Abstract

The Buschke‑Löwenstein tumor (BLT), also known as giant condyloma acuminatum, is a rare sexually transmitted disease often associated with human papillomavirus types 6 and 11. There are no specific guidelines for treating BLT. Surgery is the preferred treatment, although it can have profound consequences on a patient's quality of life. A 41‑year old male, who was HIV‑positive and a kidney transplant recipient treated with cyclosporine, was referred to the Veneto Institute of Oncology (Soft‑Tissue, Peritoneum and Melanoma Surgical Oncology Unit) after a two‑year history of perianal warts that always relapsed after surgical treatment. A multidisciplinary evaluation was conducted to assess an individually tailored treatment plan. Tailored bleomycin‑based electrochemotherapy (ECT) was proposed in order to achieve local disease control and preserve kidney function. A total of three cycles of ECT with a 25%‑reduced dose of intravenous bleomycin (11,250 IU/m²) were administered, and a complete response was achieved 20 months after the final ECT session.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Bleomycin‑based electrochemotherapy for the treatment of a Buschke‑Löwenstein tumor (perianal giant condyloma) in an HIV‑positive kidney transplant recipient: A case report

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