Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2023 Volume 25 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2023 Volume 25 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

ZDHHC9 promotes colon tumor growth by inhibiting effector T cells

  • Authors:
    • Xiaodan Chong
    • Lingxi Zhu
    • Dong Yu
    • Shasha Chen
    • Guang Wang
    • Qingzhuo Yu
    • Xianwei Ma
    • Jing Xu
    • Haitao Chen
    • Huazhang An
  • View Affiliations / Copyright

    Affiliations: Clinical Cancer Institute, Translational Medicine Center, Naval Medical University, Shanghai 200433, P.R. China, Center of Translational Medicine, Naval Medical University, Shanghai 200433, P.R. China, Department of Geriatrics, Changhai Hospital, Naval Medical University, Shanghai 200433, P.R. China
    Copyright: © Chong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 5
    |
    Published online on: November 10, 2022
       https://doi.org/10.3892/ol.2022.13591
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Zinc finger DHHC‑type palmitoyltransferase 9 (ZDHHC9) has been reported to play an important role in the occurrence and development of several types of cancer. However, its effects on colon cancer growth remain unclear. Using Gene Expression Profiling Interactive Analysis and Tumor Immune Estimation Resource, data obtained from The Cancer Genome Atlas were analyzed, and the results showed that ZDHHC9 was highly expressed in colon cancer and that patients with higher ZDHHC9 expression levels had a worse prognosis. Inhibition of ZDHHC9 expression promoted the proliferation of colon cancer cells in vitro but decreased their growth in vivo. Additionally, inhibition of ZDHHC9 expression in cancer cells enhanced CD8+ T cell‑mediated cytotoxicity in vitro and increased CD8+ T infiltration and activation in vivo. Furthermore, ZDHHC9 promoted IFN‑γ‑induced JAK/STAT1 activation and upregulated programmed death‑ligand 1 (PD‑L1) expression in colon cancer cells. In conclusion, the present findings showed that ZDHHC9 promoted colon cancer growth by upregulating the expression of PD‑L1 and inhibiting the function of CD8+ T cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Chen SJ, Wang SC and Chen YC: The immunotherapy for colorectal cancer, lung cancer and pancreatic cancer. Int J Mol Sci. 22:128362021. View Article : Google Scholar : PubMed/NCBI

2 

Fiorica F, Belluomini L, Giuliani J, Urbini B, Milella M, Frassoldati A, Pilotto S and Giorgi C: Abscopal effect and resistance reversion in nivolumab-treated non-small-cell lung cancer undergoing palliative radiotherapy: A case report. Immunotherapy. 13:971–976. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Morad G, Helmink BA, Sharma P and Wargo JA: Hallmarks of response, resistance, and toxicity to immune checkpoint blockade. Cell. 185:5762022. View Article : Google Scholar : PubMed/NCBI

4 

Dersh D, Holly J and Yewdell JW: A few good peptides: MHC class I-based cancer immunosurveillance and immunoevasion. Nat Rev Immunol. 21:116–128. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Watson RA, Tong O, Cooper R, Taylor CA, Sharma PK, de Los Aires AV, Mahé EA, Ruffieux H, Nassiri I, Middleton MR and Fairfax BP: Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8(+) T cell clone size and cytotoxicity. Sci Immunol. 6:eabj88252021. View Article : Google Scholar : PubMed/NCBI

6 

Kouskou M, Thomson DM, Brett RR, Wheeler L, Tate RJ, Pratt JA and Chamberlain LH: Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse model. Exp Neurol. 308:35–46. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Masurel-Paulet A, KalscheuerV M, Lebrun N, Hu H, Levy F, Thauvin-Robinet C, Darmency-Stamboul V, El Chehadeh S, Thevenon J, Chancenotte S, et al: Expanding the clinical phenotype of patients with a ZDHHC9 mutation. Am J Med Genet A. 64:789–795. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Hawkins E, Akarca D, Zhang M, Brkić D, Woolrich M, Baker K and Astle D: Functional network dynamics in a neurodevelopmental disorder of known genetic origin. Hum Brain Mapp. 41:530–544. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, et al: The X-linked intellectual disability gene Zdhhc9 is essential for dendrite outgrowth and inhibitory synapse formation. Cell Rep. 29:2422–2437. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Schirwani S, Wakeling E, Smith K, Study DDD and Balasubramanian M: Expanding the molecular basis and phenotypic spectrum of ZDHHC9-associated X-linked intellectual disability. Am J Med Genet A. 176:1238–1244. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Liu P, Jiao B, Zhang R, Zhao H, Zhang C, Wu M, Li D, Zhao X, Qiu Q, Li J and Ren R: Palmitoylacyltransferase Zdhhc9 inactivation mitigates leukemogenic potential of oncogenic Nras. Leukemia. 30:1225–1228. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Chen X, Ma H, Wang Z, Zhang S, Yang H and Fang Z: EZH2 palmitoylation mediated by ZDHHC5 in p53-mutant glioma drives malignant development and progression. Cancer Res. 77:4998–5010. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Noland CL, Gierke S, Schnier PD, Murray J, Sandoval WN, Sagolla M, Dey A, Hannoush RN, Fairbrother WJ and Cunningham CN: Palmitoylation of TEAD transcription factors is required for their stability and function in hippo pathway signaling. Structure. 24:179–186. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Yang Y, Hsu JM, Sun L, Chan LC, Li CW, Hsu JL, Wei Y, Xia W, Hou J, Qiu Y and Hung MC: Palmitoylation stabilizes PD-L1 to promote breast tumor growth. Cell Res. 29:83–86. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Mansilla F, Birkenkamp-Demtroder K, Kruhøffer M, Sørensen FB, Andersen CL, Laiho P, Aaltonen LA, Verspaget HW and Orntoft TF: Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups. Br J Cancer. 96:1896–1903. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Sharma P and Allison JP: Dissecting the mechanisms of immune checkpoint therapy. Nat Rev Immunol. 20:75–76. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Cerezo M, Guemiri R, Druillennec S, Girault I, Malka-Mahieu H, Shen S, Allard D, Martineau S, Welsch C, Agoussi S, et al: Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma. Nat Med. 24:1877–1886. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Lv B, Wang Y, Ma D, Cheng W, Liu J, Yong T, Chen H and Wang C: Immunotherapy: Reshape the tumor immune microenvironment. Front Immunol. 13:8441422022. View Article : Google Scholar : PubMed/NCBI

19 

Yenyuwadee S, Aliazis K, Wang Q, Christofides A, Shah R, Patsoukis N and Boussiotis VA: Immune cellular components and signaling pathways in the tumor microenvironment. Semin Cancer Biol. 86:187–201. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chong X, Zhu L, Yu D, Chen S, Wang G, Yu Q, Ma X, Xu J, Chen H, An H, An H, et al: ZDHHC9 promotes colon tumor growth by inhibiting effector T cells. Oncol Lett 25: 5, 2023.
APA
Chong, X., Zhu, L., Yu, D., Chen, S., Wang, G., Yu, Q. ... An, H. (2023). ZDHHC9 promotes colon tumor growth by inhibiting effector T cells. Oncology Letters, 25, 5. https://doi.org/10.3892/ol.2022.13591
MLA
Chong, X., Zhu, L., Yu, D., Chen, S., Wang, G., Yu, Q., Ma, X., Xu, J., Chen, H., An, H."ZDHHC9 promotes colon tumor growth by inhibiting effector T cells". Oncology Letters 25.1 (2023): 5.
Chicago
Chong, X., Zhu, L., Yu, D., Chen, S., Wang, G., Yu, Q., Ma, X., Xu, J., Chen, H., An, H."ZDHHC9 promotes colon tumor growth by inhibiting effector T cells". Oncology Letters 25, no. 1 (2023): 5. https://doi.org/10.3892/ol.2022.13591
Copy and paste a formatted citation
x
Spandidos Publications style
Chong X, Zhu L, Yu D, Chen S, Wang G, Yu Q, Ma X, Xu J, Chen H, An H, An H, et al: ZDHHC9 promotes colon tumor growth by inhibiting effector T cells. Oncol Lett 25: 5, 2023.
APA
Chong, X., Zhu, L., Yu, D., Chen, S., Wang, G., Yu, Q. ... An, H. (2023). ZDHHC9 promotes colon tumor growth by inhibiting effector T cells. Oncology Letters, 25, 5. https://doi.org/10.3892/ol.2022.13591
MLA
Chong, X., Zhu, L., Yu, D., Chen, S., Wang, G., Yu, Q., Ma, X., Xu, J., Chen, H., An, H."ZDHHC9 promotes colon tumor growth by inhibiting effector T cells". Oncology Letters 25.1 (2023): 5.
Chicago
Chong, X., Zhu, L., Yu, D., Chen, S., Wang, G., Yu, Q., Ma, X., Xu, J., Chen, H., An, H."ZDHHC9 promotes colon tumor growth by inhibiting effector T cells". Oncology Letters 25, no. 1 (2023): 5. https://doi.org/10.3892/ol.2022.13591
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team