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Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer

  • Authors:
    • Santiago Cabezas-Camarero
    • Salomé Merino-Menéndez
    • María Nieves Cabrera-Martín
    • Miguel J. Sotelo
    • José Carlos Plaza-Hernández
    • Farzin Falahat
    • María Cruz Iglesias-Moreno
    • Pedro Pérez-Segura
  • View Affiliations / Copyright

    Affiliations: Head and Neck Cancer, Neuro‑Oncology and Genetic Counseling Unit, Medical Oncology Department, Instituto de Investigación Sanitaria San Carlos, Madrid 28040, Spain, Radiology Department, Clinico San Carlos University Hospital, Madrid 28040, Spain, Nuclear Medicine Department, Clinico San Carlos University Hospital, Madrid 28040, Spain, Medical Oncology Department, Aliada Cancer Center, San Isidro 15036, Peru, Pathology Department, Clinico San Carlos University Hospital, Madrid 28040, Spain, Department of Craniomaxilofacial Surgery, Clinico San Carlos University Hospital, Madrid 28040, Spain, 9Otolaryngology‑Head and Neck Surgery, Clinico San Carlos University Hospital, Madrid 28040, Spain
    Copyright: © Cabezas-Camarero et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 37
    |
    Published online on: December 7, 2022
       https://doi.org/10.3892/ol.2022.13623
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Abstract

Novel chemo‑immunotherapy (chemo‑IO) combinations should be evaluated, which may be suitable for cisplatin‑unfit or fluoropyrimide‑ineligible patients with recurrent or metastatic squamous cell carcinoma of head and neck (R/M SCCHN) to guarantee higher and deeper responses than IO alone. The aim of the present study was to review our experience using pembrolizumab‑carboplatin‑paclitaxel (pembro + CP) in patients with R/M SCCHN. This was a retrospective study of patients with R/M SCCHN who received pembro + CP in any‑line via a compassionate‑use program. The present study evaluated safety using Common Terminology Criteria for Adverse Events v4.0, compliance, overall response rate (ORR) and disease control rate (DCR) using Response Evaluation Criteria in Solid Tumors 1.1, duration of treatment, progression‑free survival (PFS) and overall survival (OS). Between March 2020 and August 2021, 10 patients were identified (median age, 64 years; female, 60%; Eastern Cooperative Oncology Group 2, 80%). A total of 8 patients received pembro + 3‑weekly carboplatin‑paclitaxel (3wkCP). A total of 2 patients received pembro + weekly carboplatin‑paclitaxel (wkCP). Patients received a median of 3 lines (range, 0‑6) of systemic therapy prior to pembro + CP and 80% received IO in previous lines. Grade 1‑2 adverse events (AEs) occurred in 100% of patients. Grade 3‑5 AEs occurred in 30% of patients [all grade 3 (anemia, neutropenia, thrombopenia, hypertension)]. The mean numbers of pembro + wkCP and pembro + 3wkCP cycles were 2.5 and 6. The ORR (n=7) was 14% (1/7) with one complete response. The DCR was 43% (3/7). The median PFS (n=7) and OS (n=10) times since pembro + CP were 5 months (95% CI, 1‑9) and 6 months (95% CI, 0.5‑14), respectively. In this small retrospective series of heavily pretreated patients, pembro + CP was well tolerated, and compliance was high. Studies should be conducted to prospectively evaluate the safety and efficacy of this combination in patients with R/M SCCHN.
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Copy and paste a formatted citation
Spandidos Publications style
Cabezas-Camarero S, Merino-Menéndez S, Cabrera-Martín MN, Sotelo MJ, Plaza-Hernández JC, Falahat F, Iglesias-Moreno MC and Pérez-Segura P: Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer. Oncol Lett 25: 37, 2023.
APA
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M.N., Sotelo, M.J., Plaza-Hernández, J.C., Falahat, F. ... Pérez-Segura, P. (2023). Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer. Oncology Letters, 25, 37. https://doi.org/10.3892/ol.2022.13623
MLA
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M. N., Sotelo, M. J., Plaza-Hernández, J. C., Falahat, F., Iglesias-Moreno, M. C., Pérez-Segura, P."Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer". Oncology Letters 25.1 (2023): 37.
Chicago
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M. N., Sotelo, M. J., Plaza-Hernández, J. C., Falahat, F., Iglesias-Moreno, M. C., Pérez-Segura, P."Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer". Oncology Letters 25, no. 1 (2023): 37. https://doi.org/10.3892/ol.2022.13623
Copy and paste a formatted citation
x
Spandidos Publications style
Cabezas-Camarero S, Merino-Menéndez S, Cabrera-Martín MN, Sotelo MJ, Plaza-Hernández JC, Falahat F, Iglesias-Moreno MC and Pérez-Segura P: Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer. Oncol Lett 25: 37, 2023.
APA
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M.N., Sotelo, M.J., Plaza-Hernández, J.C., Falahat, F. ... Pérez-Segura, P. (2023). Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer. Oncology Letters, 25, 37. https://doi.org/10.3892/ol.2022.13623
MLA
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M. N., Sotelo, M. J., Plaza-Hernández, J. C., Falahat, F., Iglesias-Moreno, M. C., Pérez-Segura, P."Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer". Oncology Letters 25.1 (2023): 37.
Chicago
Cabezas-Camarero, S., Merino-Menéndez, S., Cabrera-Martín, M. N., Sotelo, M. J., Plaza-Hernández, J. C., Falahat, F., Iglesias-Moreno, M. C., Pérez-Segura, P."Safety and preliminary activity of pembrolizumab‑carboplatin‑paclitaxel in heavily pretreated and/or fragile patients with PDL1‑positive recurrent/metastatic head and neck cancer". Oncology Letters 25, no. 1 (2023): 37. https://doi.org/10.3892/ol.2022.13623
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