Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2023 Volume 25 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2023 Volume 25 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories

  • Authors:
    • Xi-Bo Sun
    • Wen-Wen Liu
    • Bing Wang
    • Zhen-Peng Yang
    • Hua-Zhen Tang
    • Shuai Lu
    • Yu-Ying Wang
    • Jin-Xiu Qu
    • Ben-Qiang Rao
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong 271000, P.R. China, The Second Department of General Surgery, Shanxian Central Hospital, He'ze, Shandong 274300, P.R. China, Department of Gastrointestinal Surgery, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing 100038, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 53
    |
    Published online on: December 20, 2022
       https://doi.org/10.3892/ol.2022.13639
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer has the highest incidence rate among all cancer types worldwide, seriously threatening women's health. The present retrospective study explored differences in serum lipid contents in different breast cancer (BC) subcategories and their correlation with Ki‑67 expression levels in patients with invasive BC with the aim of identifying novel diagnostic and prognostic indicators for personalized BC treatment. The study included 170 patients diagnosed with BC who were diagnosed with invasive BC by postoperative pathological examination. Data on patient age, body mass index and menopausal status were collected, in addition to estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2) and antigen Ki‑67 expression levels and pathological tumor type. Preoperative circulating lipid levels, specifically the levels of total cholesterol (TC), low‑density lipoprotein cholesterol (LDL‑C), high‑density lipoprotein cholesterol (HDL‑C), triglycerides (TG) and apolipoproteins A1 (ApoA1) and B (ApoB) were also obtained. Molecular subcategories of BC were grouped based on their immunohistochemistry. Differences in serum lipid levels between the groups were assessed, and correlations between serum lipid and Ki‑67 expression levels were explored. While TC, LDL‑C, HDL‑C and ApoA1 levels differed significantly among molecular subcategories. TG and ApoB levels did not. Circulating TC and LDL‑C levels were considerably higher in patients with triple‑negative BC (TNBC) and HER2‑positive [hormone receptor (HR)‑negative] BC than in those with luminal A and B (HER2‑negative) BC. Serum HDL‑C levels were significantly diminished in the TNBC and HER2‑positive (HR‑negative) groups compared with the luminal A and B (HER2‑negative) groups. ApoA1 levels were significantly reduced in cases of TNBC and HER2‑positive (HR‑negative) BC compared with luminal A and B BC. Ki‑67 expression levels were positively correlated with circulating TC and LDL‑C levels and inversely correlated with circulating HDL‑C and ApoA1 levels but exhibited no correlation with serum ApoB and TG levels. The results indicate that elevated TC and LDL‑C levels and diminished HDL‑C and ApoA1 levels were high‑risk factors in patients with TNBC and HER2‑positive (HR‑negative) BC, but not patients with luminal subcategories of BC. Abnormal serum lipid levels were correlated with Ki‑67 expression levels, with elevated circulating TC and LDL‑C levels and reduced circulating HDL‑C and ApoA1 levels indicating a poor prognosis in patients with BC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Cao W, Chen HD, Yu YW, Li N and Chen WQ: Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 134:783–791. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Gang H, Jingyi G, Shujiang R, Xiaobin L and Fenli L: Advances in breast cancer treatment. J Front Med. 10:11–12. 2020.(In Chinese).

3 

Long Y, Pan Z, Wenhua Z and Jingzhi G: Progress in the key enzymes in tumor lipid metabolism. Cancer Res Clin. 28:789–792. 2016.(In Chinese).

4 

Röhrig F and Schulze A: The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer. 16:732–749. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Maan M, Peters JM, Dutta M and Patterson AD: Lipid metabolism and lipophagy in cancer. Biochem Biophys Res Commun. 504:582–589. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Bian X, Liu R, Meng Y, Xing D, Xu D and Lu Z: Lipid metabolism and cancer. J Exp Med. 218:e202016062021. View Article : Google Scholar : PubMed/NCBI

7 

Beloribi-Djefaflia S, Vasseur S and Guillaumond F: Lipid metabolic reprogramming in cancer cells. Oncogenesis. 5:e1892016. View Article : Google Scholar : PubMed/NCBI

8 

Halama A, Guerrouahen BS, Pasquier J, Satheesh NJ, Suhre K and Rafii A: Nesting of colon and ovarian cancer cells in the endothelial niche is associated with alterations in glycan and lipid metabolism. Sci Rep. 7:399992017. View Article : Google Scholar : PubMed/NCBI

9 

Kouba S, Ouldamer L, Garcia C, Fontaine D, Chantome A, Vandier C, Goupille C and Potier-Cartereau M: Lipid metabolism and calcium signaling in epithelial ovarian cancer. Cell Calcium. 81:38–50. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Sung H, Siegel RL, Torre LA, Pearson-Stuttard J, Islami F, Fedewa SA, Goding Sauer A, Shuval K, Gapstur SM, Jacobs EJ, et al: Global patterns in excess body weight and the associated cancer burden. CA Cancer J Clin. 69:88–112. 2019.PubMed/NCBI

11 

Lingquan K, Xin L, Hongyuan L, Guosheng R and Kainan W: Progress on the study of breast cancer related dyslipidemia. Chin J Endocrine Surg. 11:89–91. 962017.

12 

Nelson ER: The significance of cholesterol and its metabolite, 27-hydroxycholesterol in breast cancer. Mol Cell Endocrinol. 466:73–80. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Quiroga-Morales LA, Sat-Muñoz D, Martínez-Herrera BE, Alcántara-Cadillo RR, Macías-López GG, García-Cobián TA, Bañuelos-Rizo M and Balderas-Peña LMA: Obesity and adipocytokines in breast cancer and benign breast disease. Rev Med Inst Mex Seguro Soc. 56:246–254. 2018.(In Spanish). PubMed/NCBI

14 

Qi L, Yanhui Z, Junzhe Y, Xian W, Xingmeng W, Chaoran Y, Ruyu C and Xiaoan L: Research progress on the relationship between serum lipid level and breast cancer treatment. Chin J Surg Oncol. 11:168–171. 2019.(In Chinese).

15 

Chen M, Zhao Y, Yang X, Zhao Y, Liu Q, Liu Y, Hou Y, Sun H and Jin W: NSDHL promotes triple-negative breast cancer metastasis through the TGFβ signaling pathway and cholesterol biosynthesis. Breast Cancer Res Treat. 187:349–362. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Bustreo S, Osella-Abate S, Cassoni P, Donadio M, Airoldi M, Pedani F, Papotti M, Sapino A and Castellano I: Optimal Ki67 cut-off for luminal breast cancer prognostic evaluation: A large case series study with a long-term follow-up. Breast Cancer Res Treat. 157:363–371. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B and Senn HJ; Panel members, : Strategies for subtypes-dealing with the diversity of breast cancer: Highlights of the St. Gallen international expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol. 22:1736–1747. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Lin NU, Claus E, Sohl J, Razzak AR, Arnaout A and Winer EP: Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: High incidence of central nervous system metastases. Cancer. 113:2638–2645. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Cao MD, Lamichhane S, Lundgren S, Bofin A, Fjøsne H, Giskeødegård GF and Bathen TF: Metabolic characterization of triple negative breast cancer. BMC Cancer. 14:9412014. View Article : Google Scholar : PubMed/NCBI

21 

Li LT, Jiang G, Chen Q and Zheng JN: Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep. 11:1566–1572. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Yuan P, Xu B, Wang C, Zhang C, Sun M and Yuan L: Ki-67 expression in luminal type breast cancer and its association with the clinicopathology of the cancer. Oncol Lett. 11:2101–2105. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Juríková M, Danihel Ľ, Polák Š and Varga I: Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer. Acta Histochem. 118:544–552. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Inwald EC, Klinkhammer-Schalke M, Hofstädter F, Zeman F, Koller M, Gerstenhauer M and Ortmann O: Ki-67 is a prognostic parameter in breast cancer patients: Results of a large population-based cohort of a cancer registry. Breast Cancer Res Treat. 139:539–552. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Denkert C, Budczies J, von Minckwitz G, Wienert S, Loibl S and Klauschen F: Strategies for developing Ki67 as a useful biomarker in breast cancer. Breast. 24 (Suppl 2):S67–S72. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Baek AE and Nelson ER: The contribution of cholesterol and its metabolites to the pathophysiology of breast cancer. Horm Cancer. 7:219–228. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Li JB and Jiang ZF: Chinese society of clinical oncology breast cancer guideline version 2021: Updates and interpretations. Zhonghua Yi Xue Za Zhi. 101:1835–1838. 2021.(In Chinese). PubMed/NCBI

28 

Perrotti F, Rosa C, Cicalini I, Sacchetta P, Del Boccio P, Genovesi D and Pieragostino D: Advances in lipidomics for cancer biomarkers discovery. Int J Mol Sci. 17:19922016. View Article : Google Scholar : PubMed/NCBI

29 

Szász AM, Győrffy B and Marko-Varga G: Cancer heterogeneity determined by functional proteomics. Semin Cell Dev Biol. 64:132–142. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Cappelletti V, Iorio E, Miodini P, Silvestri M, Dugo M and Daidone MG: Metabolic footprints and molecular subtypes in breast cancer. Dis Markers. 2017:76878512017. View Article : Google Scholar : PubMed/NCBI

31 

Monaco ME: Fatty acid metabolism in breast cancer subtypes. Oncotarget. 8:29487–29500. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Eiriksson FF, Nøhr MK, Costa M, Bödvarsdottir SK, Ögmundsdottir HM and Thorsteinsdottir M: Lipidomic study of cell lines reveals differences between breast cancer subtypes. PLoS One. 15:e2312892020. View Article : Google Scholar : PubMed/NCBI

33 

Furuta E, Okuda H, Kobayashi A and Watabe K: Metabolic genes in cancer: Their roles in tumor progression and clinical implications. Biochim Biophys Acta. 1805:141–152. 2010.PubMed/NCBI

34 

Kim S, Lee Y and Koo JS: Differential expression of lipid metabolism-related proteins in different breast cancer subtypes. PLoS One. 10:e01194732015. View Article : Google Scholar : PubMed/NCBI

35 

Kang HS, Lee SC, Park YS, Jeon YE, Lee JH, Jung SY, Park IH, Jang SH, Park HM, Yoo CW, et al: Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype. BMC Cancer. 11:4652011. View Article : Google Scholar : PubMed/NCBI

36 

Ligorio F, Pellegrini I, Castagnoli L, Vingiani A, Lobefaro R, Zattarin E, Santamaria M, Pupa SM, Pruneri G, de Braud F and Vernieri C: Targeting lipid metabolism is an emerging strategy to enhance the efficacy of anti-HER2 therapies in HER2-positive breast cancer. Cancer Lett. 511:77–87. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Zaidi N, Swinnen JV and Smans K: ATP-citrate lyase: A key player in cancer metabolism. Cancer Res. 72:3709–3714. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Touvier M, Fassier P, His M, Norat T, Chan DS, Blacher J, Hercberg S, Galan P, Druesne-Pecollo N and Latino-Martel P: Cholesterol and breast cancer risk: A systematic review and meta-analysis of prospective studies. Br J Nutr. 114:347–357. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Orho-Melander M, Hindy G, Borgquist S, Schulz CA, Manjer J, Melander O and Stocks T: Blood lipid genetic scores, the HMGCR gene and cancer risk: A Mendelian randomization study. Int J Epidemiol. 47:495–505. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Beeghly-Fadiel A, Khankari NK, Delahanty RJ, Shu XO, Lu Y, Schmidt MK, Bolla MK, Michailidou K, Wang Q, Dennis J, et al: A Mendelian randomization analysis of circulating lipid traits and breast cancer risk. Int J Epidemiol. 49:1117–1131. 2020. View Article : Google Scholar : PubMed/NCBI

41 

Meng Y, Wang Q and Lyu Z: Cholesterol metabolism and tumor. Zhejiang Da Xue Xue Bao Yi Xue Ban. 50:23–31. 2021.PubMed/NCBI

42 

Ha M, Sung J and Song YM: Serum total cholesterol and the risk of breast cancer in postmenopausal Korean women. Cancer Causes Control. 20:1055–1060. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Ehmsen S, Pedersen MH, Wang G, Terp MG, Arslanagic A, Hood BL, Conrads TP, Leth-Larsen R and Ditzel HJ: Increased cholesterol biosynthesis is a key characteristic of breast cancer stem cells influencing patient outcome. Cell Rep. 27:3927–3938.e6. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Fagherazzi G, Fabre A, Boutron-Ruault MC and Clavel-Chapelon F: Serum cholesterol level, use of a cholesterol-lowering drug, and breast cancer: Results from the prospective E3N cohort. Eur J Cancer Prev. 19:120–125. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Goupille C, Ouldamer L, Pinault M, Guimares C, Arbion F, Jourdan ML and Frank PG: Identification of a positive association between mammary adipose cholesterol content and indicators of breast cancer aggressiveness in a French population. J Nutr. 151:1119–1127. 2021. View Article : Google Scholar : PubMed/NCBI

46 

Ni H, Liu H and Rong G: Serum lipids and breast cancer risk: A meta-analysis of prospective cohort studies. PLoS One. 10:e01426692015. View Article : Google Scholar : PubMed/NCBI

47 

Katzke VA, Sookthai D, Johnson T, Kühn T and Kaaks R: Blood lipids and lipoproteins in relation to incidence and mortality risks for CVD and cancer in the prospective EPIC-Heidelberg cohort. BMC Med. 15:2182017. View Article : Google Scholar : PubMed/NCBI

48 

Li X, Tang H, Wang J and Xie X, Liu P, Kong Y, Ye F, Shuang Z, Xie Z and Xie X: The effect of preoperative serum triglycerides and high-density lipoprotein-cholesterol levels on the prognosis of breast cancer. Breast. 32:1–6. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Kim Y, Park SK, Han W, Kim DH, Hong YC, Ha EH, Ahn SH, Noh DY, Kang D and Yoo KY: Serum high-density lipoprotein cholesterol and breast cancer risk by menopausal status, body mass index, and hormonal receptor in Korea. Cancer Epidemiol Biomarkers Prev. 18:508–515. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Maiti B, Kundranda MN, Spiro TP and Daw HA: The association of metabolic syndrome with triple-negative breast cancer. Breast Cancer Res Treat. 121:479–483. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Fan Y, Ding X, Wang J, Ma F, Yuan P, Li Q, Zhang P and Xu B: Decreased serum HDL at initial diagnosis correlates with worse outcomes for triple-negative breast cancer but not non-TNBCs. Int J Biol Markers. 30:e200–e207. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Gallagher EJ, Zelenko Z, Neel BA, Antoniou IM, Rajan L, Kase N and LeRoith D: Elevated tumor LDLR expression accelerates LDL cholesterol-mediated breast cancer growth in mouse models of hyperlipidemia. Oncogene. 36:6462–6471. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Scheinman EJ, Rostoker R and Leroith D: Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways. Mol Cell Endocrinol. 374:101–107. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Hoque M, Rentero C, Conway JR, Murray RZ, Timpson P, Enrich C and Grewal T: The cross-talk of LDL-cholesterol with cell motility: Insights from the Niemann pick type C1 mutation and altered integrin trafficking. Cell Adh Migr. 9:384–391. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Antalis CJ, Uchida A, Buhman KK and Siddiqui RA: Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification. Clin Exp Metastasis. 28:733–741. 2011. View Article : Google Scholar : PubMed/NCBI

56 

dos Santos CR, Domingues G, Matias I, Matos J, Fonseca I, de Almeida JM and Dias S: LDL-cholesterol signaling induces breast cancer proliferation and invasion. Lipids Health Dis. 13:162014. View Article : Google Scholar : PubMed/NCBI

57 

Ye J, Xia X, Dong W, Hao H, Meng L, Yang Y, Wang R, Lyu Y and Liu Y: Cellular uptake mechanism and comparative evaluation of antineoplastic effects of paclitaxel-cholesterol lipid emulsion on triple-negative and non-triple-negative breast cancer cell lines. Int J Nanomedicine. 11:4125–4140. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Catasus L, Gallardo A, Llorente-Cortes V, Escuin D, Muñoz J, Tibau A, Peiro G, Barnadas A and Lerma E: Low-density lipoprotein receptor-related protein 1 is associated with proliferation and invasiveness in Her-2/neu and triple-negative breast carcinomas. Hum Pathol. 42:1581–1588. 2011. View Article : Google Scholar : PubMed/NCBI

59 

van Duijnhoven FJ, Bueno-De-Mesquita HB, Calligaro M, Jenab M, Pischon T, Jansen EH, Frohlich J, Ayyobi A, Overvad K, Toft-Petersen AP, et al: Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European prospective investigation into cancer and nutrition. Gut. 60:1094–1102. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Borgquist S, Butt T, Almgren P, Shiffman D, Stocks T, Orho-Melander M, Manjer J and Melander O: Apolipoproteins, lipids and risk of cancer. Int J Cancer. 138:2648–2656. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Zuo M, Rashid A, Wang Y, Jain A, Li D, Behari A, Kapoor VK, Koay EJ, Chang P, Vauthey JN, et al: RNA sequencing-based analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer. Oncotarget. 7:35302–35312. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Zamanian-Daryoush M, Lindner D, Tallant TC, Wang Z, Buffa J, Klipfell E, Parker Y, Hatala D, Parsons-Wingerter P, Rayman P, et al: The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects. J Biol Chem. 288:21237–21252. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Han C, Zhang HT, Du L, Liu X, Jing J, Zhao X, Yang X and Tian B: Serum levels of leptin, insulin, and lipids in relation to breast cancer in China. Endocrine. 26:19–24. 2005. View Article : Google Scholar : PubMed/NCBI

64 

Chang SJ, Hou MF, Tsai SM, Wu SH, Hou LA, Ma H, Shann TY, Wu SH and Tsai LY: The association between lipid profiles and breast cancer among Taiwanese women. Clin Chem Lab Med. 45:1219–1223. 2007. View Article : Google Scholar : PubMed/NCBI

65 

Holm C, Rayala S, Jirström K, Stål O, Kumar R and Landberg G: Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients. J Natl Cancer Inst. 98:671–680. 2006. View Article : Google Scholar : PubMed/NCBI

66 

Lin X, Hong S, Huang J, Chen Y, Chen Y and Wu Z: Plasma apolipoprotein A1 levels at diagnosis are independent prognostic factors in invasive ductal breast cancer. Discov Med. 23:247–258. 2017.PubMed/NCBI

67 

Luporsi E, André F, Spyratos F, Martin PM, Jacquemier J, Penault-Llorca F, Tubiana-Mathieu N, Sigal-Zafrani B, Arnould L, Gompel A, et al: Ki-67: Level of evidence and methodological considerations for its role in the clinical management of breast cancer: Analytical and critical review. Breast Cancer Res Treat. 132:895–915. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Haroon S, Hashmi AA, Khurshid A, Kanpurwala MA, Mujtuba S, Malik B and Faridi N: Ki67 index in breast cancer: Correlation with other prognostic markers and potential in pakistani patients. Asian Pac J Cancer Prev. 14:4353–4358. 2013. View Article : Google Scholar : PubMed/NCBI

69 

de Azambuja E, Cardoso F, de Castro G Jr, Colozza M, Mano MS, Durbecq V, Sotiriou C, Larsimont D, Piccart-Gebhart MJ and Paesmans M: Ki-67 as prognostic marker in early breast cancer: A meta-analysis of published studies involving 12,155 patients. Br J Cancer. 96:1504–1513. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Petrelli F, Viale G, Cabiddu M and Barni S: Prognostic value of different cut-off levels of Ki-67 in breast cancer: A systematic review and meta-analysis of 64,196 patients. Breast Cancer Res Treat. 153:477–491. 2015. View Article : Google Scholar : PubMed/NCBI

71 

Alco G, Bozdogan A, Selamoglu D, Pilanci KN, Tuzlali S, Ordu C, Igdem S, Okkan S, Dincer M, Demir G and Ozmen V: Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients. Oncol Lett. 9:1046–1054. 2015. View Article : Google Scholar : PubMed/NCBI

72 

Kanyilmaz G, Yavuz BB, Aktan M, Karaağaç M, Uyar M and Fındık S: Prognostic importance of Ki-67 in breast cancer and its relationship with other prognostic factors. Eur J Breast Health. 15:256–261. 2019. View Article : Google Scholar : PubMed/NCBI

73 

Soliman NA and Yussif SM: Ki-67 as a prognostic marker according to breast cancer molecular subtype. Cancer Biol Med. 13:496–504. 2016. View Article : Google Scholar : PubMed/NCBI

74 

Hashmi AA, Hashmi KA, Irfan M, Khan SM, Edhi MM, Ali JP, Hashmi SK, Asif H, Faridi N and Khan A: Ki67 index in intrinsic breast cancer subtypes and its association with prognostic parameters. BMC Res Notes. 12:6052019. View Article : Google Scholar : PubMed/NCBI

75 

Mitrović O, Čokić V, Đikić D, Budeč M, Vignjević S, Subotički T, Gulan M, Radović S and Furtula S: Correlation between ER, PR, HER-2, Bcl-2, p53, proliferative and apoptotic indexes with HER-2 gene amplification and TOP2A gene amplification and deletion in four molecular subtypes of breast cancer. Target Oncol. 9:367–379. 2014. View Article : Google Scholar : PubMed/NCBI

76 

Ricoult SJH, Yecies JL, Ben-Sahra I and Manning BD: Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. 35:1250–1260. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sun X, Liu W, Wang B, Yang Z, Tang H, Lu S, Wang Y, Qu J and Rao B: Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories. Oncol Lett 25: 53, 2023.
APA
Sun, X., Liu, W., Wang, B., Yang, Z., Tang, H., Lu, S. ... Rao, B. (2023). Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories. Oncology Letters, 25, 53. https://doi.org/10.3892/ol.2022.13639
MLA
Sun, X., Liu, W., Wang, B., Yang, Z., Tang, H., Lu, S., Wang, Y., Qu, J., Rao, B."Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories". Oncology Letters 25.2 (2023): 53.
Chicago
Sun, X., Liu, W., Wang, B., Yang, Z., Tang, H., Lu, S., Wang, Y., Qu, J., Rao, B."Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories". Oncology Letters 25, no. 2 (2023): 53. https://doi.org/10.3892/ol.2022.13639
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X, Liu W, Wang B, Yang Z, Tang H, Lu S, Wang Y, Qu J and Rao B: Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories. Oncol Lett 25: 53, 2023.
APA
Sun, X., Liu, W., Wang, B., Yang, Z., Tang, H., Lu, S. ... Rao, B. (2023). Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories. Oncology Letters, 25, 53. https://doi.org/10.3892/ol.2022.13639
MLA
Sun, X., Liu, W., Wang, B., Yang, Z., Tang, H., Lu, S., Wang, Y., Qu, J., Rao, B."Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories". Oncology Letters 25.2 (2023): 53.
Chicago
Sun, X., Liu, W., Wang, B., Yang, Z., Tang, H., Lu, S., Wang, Y., Qu, J., Rao, B."Correlations between serum lipid and Ki‑67 levels in different breast cancer molecular subcategories". Oncology Letters 25, no. 2 (2023): 53. https://doi.org/10.3892/ol.2022.13639
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team