Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2023 Volume 25 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2023 Volume 25 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis

  • Authors:
    • Haoyi Xiang
    • Xuning Shen
    • Engeng Chen
    • Wei Chen
    • Zhangfa Song
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China, Cancer Institute of Integrated Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, P.R. China
    Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 63
    |
    Published online on: December 23, 2022
       https://doi.org/10.3892/ol.2022.13650
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Colorectal cancer (CRC) has high morbidity and mortality, particularly if diagnosed at an advanced stage. Although there have been several studies on CRC, few have investigated the relationship between oncosis and CRC. Thus, the purpose of the present study was to identify oncosis‑related long noncoding RNAs (lncRNAs) and to establish a clinical prognostic model. Original data were acquired from The Cancer Genome Atlas database and PubMed. Differentially expressed oncosis‑related lncRNAs (DEorlncRNAs) were identified and were subsequently formed into pairs. Next, a series of tests and analyses, including both univariate and multivariate analyses, as well as Lasso and Cox regression analyses, were performed to establish a receiver operating characteristic curve. A cut‑off point was subsequently used to divide the samples into groups labelled as high‑ or low‑risk. Thus, a model was established and evaluated in several dimensions. Six pairs of DEorlncRNAs associated with prognosis according to the algorithm were screened out and the CRC cases were divided into high‑ and low‑risk groups. Significant differences between patients in the different risk groups were observed for several traits, including survival outcomes, clinical pathology characteristics, immune cell infiltration status and drug sensitivity. In addition, PCR and flow cytometry were performed to further verify the model. In summary, a new risk model algorithm based on six pairs of DEorlncRNAs in CRC, which does not require specific data regarding the level of gene expression, was established and validated. This algorithm may be used to predict patient prognosis, immune cell infiltration and drug sensitivity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Dekker E, Tanis P, Vleugels J, Kasi P and Wallace M: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Weerasinghe P and Buja LM: Oncosis: An important non-apoptotic mode of cell death. Exp Mol Pathol. 93:302–308. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Trump BF and Berezesky IK: Calcium-mediated cell injury and cell death. FASEB J. 9:219–228. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Peters AA, Jamaludin SYN, Yapa KTDS, Chalmers S, Wiegmans AP, Lim HF, Milevskiy MJG, Azimi I, Davis FM, Northwood KS, et al: Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells. Oncogene. 36:6490–6500. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Mills EM, Xu D, Fergusson MM, Combs CA, Xu Y and Finkel T: Regulation of cellular oncosis by uncoupling protein 2. J Biol Chem. 277:27385–27392. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Majno G and Joris I: Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol. 146:3–15. 1995.PubMed/NCBI

9 

Wang L, Mai Z, Zhao M, Wang B, Yu S, Wang X and Chen T: Aspirin induces oncosis in tumor cells. Apoptosis. 24:758–772. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Guan R, Chen Y, Zeng L, Rees TW, Jin C, Huang J, Chen ZS, Ji L and Chao H: Oncosis-inducing cyclometalated iridium(iii) complexes. Chem Sci. 9:5183–5190. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, et al: The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res. 22:1775–1789. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR and Goel A: Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis. Carcinogenesis. 35:2731–2739. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Schmitt AM and Chang HY: Gene regulation: Long RNAs wire up cancer growth. Nature. 500:536–537. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Schmidt LH, Spieker T, Koschmieder S, Schäffers S, Humberg J, Jungen D, Bulk E, Hascher A, Wittmer D, Marra A, et al: The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol. 6:1984–1992. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Yan X, Hu Z, Feng Y, Hu X, Yuan J, Zhao SD, Zhang Y, Yang L, Shan W, He Q, et al: Comprehensive genomic characterization of long non-coding RNAs across human cancers. Cancer Cell. 28:529–540. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Matsumura H, Shimizu Y, Ohsawa Y, Kawahara A, Uchiyama Y and Nagata S: Necrotic death pathway in Fas receptor signaling. J Cell Biol. 151:1247–1256. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B and Tschopp J: Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 1:489–495. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Tanabe K, Nakanishi H, Maeda H, Nishioku T, Hashimoto K, Liou SY, Akamine A and Yamamoto K: A predominant apoptotic death pathway of neuronal PC12 cells induced by activated microglia is displaced by a non-apoptotic death pathway following blockage of caspase-3-dependent cascade. J Biol Chem. 274:15725–15731. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Akimoto M, Hayashi JI, Nakae S, Saito H and Takenaga K: Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer. Cell Death Dis. 7:e20572016. View Article : Google Scholar : PubMed/NCBI

20 

Chen YG, Satpathy AT and Chang HY: Gene regulation in the immune system by long noncoding RNAs. Nat Immunol. 18:962–972. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Li Y, Jiang T, Zhou W, Li J, Li X, Wang Q, Jin X, Yin J, Chen L, Zhang Y, et al: Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers. Nat Commun. 11:10002020. View Article : Google Scholar : PubMed/NCBI

22 

Fang T, Liang T, Wang Y, Wu H, Liu S, Xie L, Zhang Z, Liang J, Yao C, Tan Y and Wang C: An early-onset advanced rectal cancer patient with increased KRAS gene copy number showed A primary resistance to cetuximab in combination with chemotherapy: A case report. Front Oncol. 11:7555782021. View Article : Google Scholar : PubMed/NCBI

23 

Lv Y, Lin SY, Hu FF, Ye Z, Zhang Q, Wang Y and Guo AY: Landscape of cancer diagnostic biomarkers from specifically expressed genes. Brief Bioinform. 21:2175–2184. 2020. View Article : Google Scholar : PubMed/NCBI

24 

Tomczak K, Czerwinska P and Wiznerowicz M: The cancer genome atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

25 

Fiorini N, Lipman DJ and Lu Z: Towards PubMed 2.0. Elife. 6:e288012017. View Article : Google Scholar : PubMed/NCBI

26 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

27 

Akaike H: A new look at the statistical model identification. IEEE Trans Automat Contr AC. 19:716–723. 1974. View Article : Google Scholar

28 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Strutner J, Ramchandar N, Dubey S, Gamboa M, Vanderpool MK, Mueller T, Wang W, Cannavino C, Tovar Padua L, Malicki D and Pong A: Comparison of RT-PCR cycle threshold values from respiratory specimens in symptomatic and asymptomatic children with SARS-CoV-2 infection. Clin Infect Dis: ciab403. 2021.(Epub ahead of print). View Article : Google Scholar

30 

Chen Y, Lu B, Yang Q, Fearns C, Yates JR III and Lee JD: Combined integrin phosphoproteomic analyses and small interfering RNA-based functional screening identify key regulators for cancer cell adhesion and migration. Cancer Res. 69:3713–3720. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Warnes G and Martins S: Real-time flow cytometry for the kinetic analysis of oncosis. Cytometry A. 79:181–191. 2011. View Article : Google Scholar : PubMed/NCBI

32 

D'Arcy MS: Cell death: A review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 43:582–592. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Luo D, Ni Q, Ji A, Gu W, Wu J and Jiang C: Dehydroabietic acid derivative QC4 induces gastric cancer cell death via oncosis and apoptosis. Biomed Res Int. 2016:25810612016. View Article : Google Scholar : PubMed/NCBI

34 

Huarte M: The emerging role of lncRNAs in cancer. Nat Med. 21:1253–1261. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zhang W, Fang D, Li S, Bao X, Jiang L and Sun X: Construction and validation of a novel ferroptosis-related lncRNA signature to predict prognosis in colorectal cancer patients. Front Genet. 12:7093292021. View Article : Google Scholar : PubMed/NCBI

36 

Yu J, Mao W, Xu B and Chen M: Construction and validation of an autophagy-related long noncoding RNA signature for prognosis prediction in kidney renal clear cell carcinoma patients. Cancer Med. 10:2359–2369. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Ghafouri-Fard S and Taheri M: Long non-coding RNA signature in gastric cancer. Exp Mol Pathol. 113:1043652020. View Article : Google Scholar : PubMed/NCBI

38 

Liu S, Cao Q, An G, Yan B and Lei L: Identification of the 3-lncRNA signature as a prognostic biomarker for colorectal cancer. Int J Mol Sci. 21:93592020. View Article : Google Scholar : PubMed/NCBI

39 

Wei J, Ge X, Tang Y, Qian Y, Lu W, Jiang K, Fang Y, Hwang M, Fu D, Xiao Q and Ding K: An autophagy-related long noncoding RNA signature contributes to poor prognosis in colorectal cancer. J Oncol. 2020:47289472020. View Article : Google Scholar : PubMed/NCBI

40 

Tang R, Wu Z, Rong Z, Xu J, Wang W, Zhang B, Yu X and Shi S: Ferroptosis-related lncRNA pairs to predict the clinical outcome and molecular characteristics of pancreatic ductal adenocarcinoma. Brief Bioinform. 23:bbab3882022. View Article : Google Scholar : PubMed/NCBI

41 

Keulers TG, Koch A, van Gisbergen MW, Barbeau LMO, Zonneveld MI, de Jong MC, Savelkouls KGM, Wanders RG, Bussink J, Melotte V and Rouschop KMA: ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer. Autophagy. 18:1898–1914. 2022. View Article : Google Scholar : PubMed/NCBI

42 

Llambi F, Wang YM, Victor B, Yang M, Schneider DM, Gingras S, Parsons MJ, Zheng JH, Brown SA, Pelletier S, et al: BOK is a non-canonical BCL-2 family effector of apoptosis regulated by ER-associated degradation. Cell. 165:421–433. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Dai W, Mu L, Cui Y, Li Y, Chen P, Xie H and Wang X: Long non-coding RNA CASC2 enhances berberine-induced cytotoxicity in colorectal cancer cells by silencing BCL2. Mol Med Rep. 20:995–1006. 2019.PubMed/NCBI

44 

Mazzu YZ, Liao Y, Nandakumar S, Sjöström M, Jehane LE, Ghale R, Govindarajan B, Gerke TA, Lee GM, Luo JH, et al: Dynamic expression of SNAI2 in prostate cancer predicts tumor progression and drug sensitivity. Mol Oncol. 16:2451–2469. 2022. View Article : Google Scholar : PubMed/NCBI

45 

Findlay VJ, Wang C, Nogueira LM, Hurst K, Quirk D, Ethier SP, Staveley O'Carroll KF, Watson DK and Camp ER: SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression. Mol Cancer Ther. 13:2713–2726. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Du F, Li X, Feng W, Qiao C, Chen J, Jiang M, Qiu Z, Qian M, Tian D, Nie Y, et al: SOX13 promotes colorectal cancer metastasis by transactivating SNAI2 and c-MET. Oncogene. 39:3522–3540. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Funke L, Bracht T, Oeck S, Schork K, Stepath M, Dreesmann S, Eisenacher M, Sitek B and Schramm A: NTRK1/TrkA signaling in neuroblastoma cells induces nuclear reorganization and intra-nuclear aggregation of lamin A/C. Cancers (Basel). 13:52932021. View Article : Google Scholar : PubMed/NCBI

48 

Willis ND, Cox TR, Rahman-Casañs SF, Smits K, Przyborski SA, van den Brandt P, van Engeland M, Weijenberg M, Wilson RG, de Bruïne A and Hutchison CJ: Lamin A/C is a risk biomarker in colorectal cancer. PLoS One. 3:e29882008. View Article : Google Scholar : PubMed/NCBI

49 

Kim DY, Cheong HT, Ra CS, Kimura K and Jung BD: Effect of 5-azacytidine (5-aza) on UCP2 expression in human liver and colon cancer cells. Int J Med Sci. 18:2176–2186. 2021. View Article : Google Scholar : PubMed/NCBI

50 

Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, et al: UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep. 28:2306–2316.e5. 2019. View Article : Google Scholar : PubMed/NCBI

51 

Qiao C, Wei L, Dai Q, Zhou Y, Yin Q, Li Z, Xiao Y, Guo Q and Lu N: UCP2-related mitochondrial pathway participates in oroxylin A-induced apoptosis in human colon cancer cells. J Cell Physiol. 230:1054–1063. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Kim G, Lim S and Kim KD: N-myc downstream-regulated gene 2 (NDRG2) function as a positive regulator of apoptosis: A new insight into NDRG2 as a tumor suppressor. Cells. 10:26492021. View Article : Google Scholar : PubMed/NCBI

53 

Moreno E and Barquero-Calvo E: The role of neutrophils in brucellosis. Microbiol Mol Biol Rev. 84:e00048–20. 2020. View Article : Google Scholar : PubMed/NCBI

54 

Davidson WF, Haudenschild C, Kwon J and Williams MS: T cell receptor ligation triggers novel nonapoptotic cell death pathways that are Fas-independent or Fas-dependent. J Immunol. 169:6218–6230. 2002. View Article : Google Scholar : PubMed/NCBI

55 

Cho U, Kim B, Kim S, Han Y and Song YS: Pro-inflammatory M1 macrophage enhances metastatic potential of ovarian cancer cells through NF-κB activation. Mol Carcinog. 57:235–242. 2018. View Article : Google Scholar : PubMed/NCBI

56 

Wang S, Zheng B, Zhao H, Li Y, Zhang X and Wen J: Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis. Int J Mol Med. 47:352021. View Article : Google Scholar : PubMed/NCBI

57 

Wu Y, Zhang L, He S, Guan B, He A, Yang K, Gong Y, Li X and Zhou L: Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer. Aging (Albany NY). 12:23306–23325. 2020.PubMed/NCBI

58 

Yang F, Zhang J, Li B, Zhao Z, Liu Y, Zhao Z, Jing S and Wang G: Identification of potential lncRNAs and miRNAs as diagnostic biomarkers for papillary thyroid carcinoma based on machine learning. Int J Endocrinol. 2021:39844632021. View Article : Google Scholar : PubMed/NCBI

59 

Xu Y, Chen J, Yang Z and Xu L: Identification of RNA expression profiles in thyroid cancer to construct a competing endogenous RNA (ceRNA) network of mRNAs, long noncoding RNAs (lncRNAs), and microRNAs (miRNAs). Med Sci Monit. 25:1140–1154. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Vishnubalaji R and Alajez NM: Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling. Sci Rep. 11:154102021. View Article : Google Scholar : PubMed/NCBI

61 

Ye Z, Zheng M, Zeng Y, Wei S, Wang Y, Lin Z, Shu C, Xie Y, Zheng Q and Chen L: Bioinformatics analysis reveals an association between cancer cell stemness, gene mutations, and the immune microenvironment in stomach adenocarcinoma. Front Genet. 11:5954772020. View Article : Google Scholar : PubMed/NCBI

62 

Liu Z, Liu L, Weng S, Guo C, Dang Q, Xu H, Wang L, Lu T, Zhang Y, Sun Z and Han X: Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer. Nat Commun. 13:8162022. View Article : Google Scholar : PubMed/NCBI

63 

Song W, Ren J, Yuan W, Xiang R, Ge Y and Fu T: N6-methyladenosine-related lncRNA signature predicts the overall survival of colorectal cancer patients. Genes (Basel). 12:13752021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiang H, Shen X, Chen E, Chen W and Song Z: Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis. Oncol Lett 25: 63, 2023.
APA
Xiang, H., Shen, X., Chen, E., Chen, W., & Song, Z. (2023). Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis. Oncology Letters, 25, 63. https://doi.org/10.3892/ol.2022.13650
MLA
Xiang, H., Shen, X., Chen, E., Chen, W., Song, Z."Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis". Oncology Letters 25.2 (2023): 63.
Chicago
Xiang, H., Shen, X., Chen, E., Chen, W., Song, Z."Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis". Oncology Letters 25, no. 2 (2023): 63. https://doi.org/10.3892/ol.2022.13650
Copy and paste a formatted citation
x
Spandidos Publications style
Xiang H, Shen X, Chen E, Chen W and Song Z: Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis. Oncol Lett 25: 63, 2023.
APA
Xiang, H., Shen, X., Chen, E., Chen, W., & Song, Z. (2023). Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis. Oncology Letters, 25, 63. https://doi.org/10.3892/ol.2022.13650
MLA
Xiang, H., Shen, X., Chen, E., Chen, W., Song, Z."Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis". Oncology Letters 25.2 (2023): 63.
Chicago
Xiang, H., Shen, X., Chen, E., Chen, W., Song, Z."Construction and validation of a novel algorithm based on oncosis‑related lncRNAs comprising the immune landscape and prediction of colorectal cancer prognosis". Oncology Letters 25, no. 2 (2023): 63. https://doi.org/10.3892/ol.2022.13650
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team