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Article

Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma

  • Authors:
    • Yong Feng
    • Wei Wei
    • Shuo Guo
    • Bao-Qing Li
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Outpatient, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China, Department of Gastroenterology, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Article Number: 67
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    Published online on: December 23, 2022
       https://doi.org/10.3892/ol.2022.13653
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Abstract

There are currently no well‑established treatment strategies for early esophageal squamous cell carcinoma (ESCC) for patients with only positive lateral margin (LM+) following endoscopic resection (ER). The present study aimed to find a treatment strategy for patients with early ESCC with non‑curative resection (non‑CR) and only LM+ following ER. In total, 511 patients with early ESCC treated at the Fourth Hospital of Hebei Medical University (Shijiazhuang, China) with ER were retrospectively analyzed, 41 of which (8%) were patients with only LM+ after non‑CR. Of these, 28 patients received re‑ER and 13 received additional surgical treatment. The clinicopathological characteristics of patients were analyzed and those who underwent additional surgery vs. re‑ER were compared. Residual cancer cells were found in 27 patients (27/41, 65.9%) following re‑ER or additional surgery. A significant increase in residual cancer cells was observed in patients with poorly differentiated cancer and patients with multiple LM+ (P=0.03 and P=0.015, respectively). Older patients and patients with single LM+ tended to choose re‑ER (P=0.023 and P=0.038, respectively). In addition, there were three cases (3/13, 23.1%) of lymph node metastasis in the additional surgery group. However, within the limited follow‑up time (mean, 36.1±24.1 months), no recurrence or metastasis was found in the remaining patients. The results showed that re‑ER may be a more suitable additional therapy compared with surgery for patients with LM+ following non‑CR, at least in the medium‑term.
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Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Wei W, Guo S and Li B: Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma. Oncol Lett 25: 67, 2023.
APA
Feng, Y., Wei, W., Guo, S., & Li, B. (2023). Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma. Oncology Letters, 25, 67. https://doi.org/10.3892/ol.2022.13653
MLA
Feng, Y., Wei, W., Guo, S., Li, B."Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma". Oncology Letters 25.2 (2023): 67.
Chicago
Feng, Y., Wei, W., Guo, S., Li, B."Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma". Oncology Letters 25, no. 2 (2023): 67. https://doi.org/10.3892/ol.2022.13653
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Wei W, Guo S and Li B: Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma. Oncol Lett 25: 67, 2023.
APA
Feng, Y., Wei, W., Guo, S., & Li, B. (2023). Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma. Oncology Letters, 25, 67. https://doi.org/10.3892/ol.2022.13653
MLA
Feng, Y., Wei, W., Guo, S., Li, B."Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma". Oncology Letters 25.2 (2023): 67.
Chicago
Feng, Y., Wei, W., Guo, S., Li, B."Additional endoscopic treatments for patients with positive lateral margins after endoscopic resection of early esophageal squamous cell carcinoma". Oncology Letters 25, no. 2 (2023): 67. https://doi.org/10.3892/ol.2022.13653
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