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Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer

  • Authors:
    • Yue Yu
    • Zhihua Xu
    • Hao Ni
    • Mengxian Jin
    • Chen Dai
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Endocrinology, Suzhou Xiangcheng People's Hospital, Suzhou, Jiangsu 215131, P.R. China, Department of Thyroid and Breast Surgery, Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 73
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    Published online on: January 2, 2023
       https://doi.org/10.3892/ol.2023.13659
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Abstract

Colon cancer associated transcript‑1 (CCAT1) is known to play an important role in numerous types of human cancer, including bladder, prostate and ovarian cancer. However, a consistent perspective has not been established in digestive system cancer (DSC). To explore the prognostic value of CCAT1 in patients with DSC, a meta‑analysis was performed. A systematic search of PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Chinese Biological Medical Literature database, Cochrane Library and WanFang database was applied to select eligible articles. Pooled odds ratios (ORs) or hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were calculated to estimate the effects of CCAT1 on pathological or clinical features. A total of 1,719 patients from 12 eligible articles were enrolled in the meta‑analysis. The results revealed that elevated CCAT1 expression was significantly related to larger tumor size (OR, 1.81; 95% CI, 1.31‑2.48), poorer differentiation (OR, 0.45; 95% CI, 0.31‑0.64), earlier lymph node metastasis (OR, 3.14; 95% CI, 2.34‑4.22) and advanced TNM stage (OR, 3.08; 95% CI, 2.07‑4.59). In addition, high CCAT1 expression predicted a poorer outcome for overall survival rate (HR, 2.37; 95% CI, 2.11‑2.67) and recurrence‑free survival rate (HR, 2.16, 95% CI, 1.31‑3.57). High expression levels of CCAT1 were therefore related to unfavorable clinical outcomes of patients with DSC. These results demonstrated that CCAT1 could serve as a prognostic predictor in human DSC.
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Copy and paste a formatted citation
Spandidos Publications style
Yu Y, Xu Z, Ni H, Jin M and Dai C: Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer. Oncol Lett 25: 73, 2023.
APA
Yu, Y., Xu, Z., Ni, H., Jin, M., & Dai, C. (2023). Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer. Oncology Letters, 25, 73. https://doi.org/10.3892/ol.2023.13659
MLA
Yu, Y., Xu, Z., Ni, H., Jin, M., Dai, C."Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer". Oncology Letters 25.2 (2023): 73.
Chicago
Yu, Y., Xu, Z., Ni, H., Jin, M., Dai, C."Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer". Oncology Letters 25, no. 2 (2023): 73. https://doi.org/10.3892/ol.2023.13659
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y, Xu Z, Ni H, Jin M and Dai C: Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer. Oncol Lett 25: 73, 2023.
APA
Yu, Y., Xu, Z., Ni, H., Jin, M., & Dai, C. (2023). Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer. Oncology Letters, 25, 73. https://doi.org/10.3892/ol.2023.13659
MLA
Yu, Y., Xu, Z., Ni, H., Jin, M., Dai, C."Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer". Oncology Letters 25.2 (2023): 73.
Chicago
Yu, Y., Xu, Z., Ni, H., Jin, M., Dai, C."Clinicopathological and prognostic value of long non‑coding RNA CCAT1 expression in patients with digestive system cancer". Oncology Letters 25, no. 2 (2023): 73. https://doi.org/10.3892/ol.2023.13659
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