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Article

Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas

  • Authors:
    • Takeshi Fujita
    • Kazuko Sakai
    • Natsumi Uehara
    • Yujiro Hoshi
    • Anjin Mori
    • Hajime Koyama
    • Mitsuo Sato
    • Kazuya Saito
    • Yasuhiro Osaki
    • Kazuto Nishio
    • Katsumi Doi
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan, Department of Genome Biology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan, Department of Otorhinolaryngology, Mitsui Memorial Hospital, Tokyo 101-8643, Japan, Department of Otorhinolaryngology - Head and Neck Surgery, NTT Medical Center Tokyo, Tokyo 141-8625, Japan, Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo Hospital, Tokyo 113-8655, Japan, Department of Otolaryngology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan, Department of Otorhinolaryngology, Izumi City General Hospital, Izumi, Osaka 594-0073, Japan, Department of Genome Biology, Kindai University Faculty of Medicine, Osaka‑Sayama, Osaka 589-8511, Japan
  • Article Number: 121
    |
    Published online on: February 8, 2023
       https://doi.org/10.3892/ol.2023.13707
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Abstract

Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle. Despite the increasing diagnosis of sporadic VS over the past decade, the use of traditional microsurgeries to treat VS has decreased. This is likely a result of the adoption of serial imaging as the most common initial evaluation and treatment strategy, especially for small‑sized VS. However, the pathobiology of VSs remains unclear, and elucidating the genetic information of tumor tissue may reveal novel insights. The present study performed a comprehensive genomic analysis of all exons in the key tumor suppressor and oncogenes from 10 small (<15 mm) sporadic VS samples. The evaluations identified NF2, SYNE1, IRS2, APC, CIC, SDHC, BRAF, NUMA1, EXT2, HRAS, BCL11B, MAGI1, RNF123, NLRP1, ASXL1, ADAMTS20, TAF1L, XPC, DDB2 and ETS1 as mutated genes. The current study could not draw any new conclusions about the relationship between VS‑related hearing loss and gene mutations; however, it did reveal that NF2 was the most frequently mutated gene in small sporadic VS.
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Copy and paste a formatted citation
Spandidos Publications style
Fujita T, Sakai K, Uehara N, Hoshi Y, Mori A, Koyama H, Sato M, Saito K, Osaki Y, Nishio K, Nishio K, et al: Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas. Oncol Lett 25: 121, 2023.
APA
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H. ... Doi, K. (2023). Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas. Oncology Letters, 25, 121. https://doi.org/10.3892/ol.2023.13707
MLA
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H., Sato, M., Saito, K., Osaki, Y., Nishio, K., Doi, K."Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas". Oncology Letters 25.3 (2023): 121.
Chicago
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H., Sato, M., Saito, K., Osaki, Y., Nishio, K., Doi, K."Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas". Oncology Letters 25, no. 3 (2023): 121. https://doi.org/10.3892/ol.2023.13707
Copy and paste a formatted citation
x
Spandidos Publications style
Fujita T, Sakai K, Uehara N, Hoshi Y, Mori A, Koyama H, Sato M, Saito K, Osaki Y, Nishio K, Nishio K, et al: Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas. Oncol Lett 25: 121, 2023.
APA
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H. ... Doi, K. (2023). Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas. Oncology Letters, 25, 121. https://doi.org/10.3892/ol.2023.13707
MLA
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H., Sato, M., Saito, K., Osaki, Y., Nishio, K., Doi, K."Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas". Oncology Letters 25.3 (2023): 121.
Chicago
Fujita, T., Sakai, K., Uehara, N., Hoshi, Y., Mori, A., Koyama, H., Sato, M., Saito, K., Osaki, Y., Nishio, K., Doi, K."Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas". Oncology Letters 25, no. 3 (2023): 121. https://doi.org/10.3892/ol.2023.13707
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