Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2023 Volume 25 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2023 Volume 25 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes

  • Authors:
    • Beatriz Navarro
    • Chrysoula Margioula-Siarkou
    • Stamatios Petousis
    • Anne Floquet
    • Guillame Babin
    • Frederic Guyon
  • View Affiliations / Copyright

    Affiliations: Gynaecologic Oncology Unit, Institute Bergonie, Bordeaux 33076, France
  • Article Number: 122
    |
    Published online on: February 8, 2023
       https://doi.org/10.3892/ol.2023.13708
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lymphovascular space invasion (LVSI) is considered to be a poor prognostic factor in endometrial cancer. However, management of patients with early‑stage endometrial cancer with positive LVSI remains controversial. The main objective of the present study was to investigate whether surgical restaging of such patients has a significant effect on survival outcomes or may be otherwise omitted. A retrospective cohort study was conducted at the Gynaecologic Oncology Unit, Insitut Bergonie, Bordeaux, France for the period January 2003‑December 2019. The present study included patients with definitive histopathological diagnosis of early‑stage, grade 1‑2 endometrial cancer with positive LVSI. Patients were divided into two groups: Those being restaged with pelvic and para‑aortic lymphadenectomy (group 1) and those not restaged and receiving complementary therapy (group 2). The primary outcomes of the study were overall survival and progression‑free survival. Epidemiological data, clinical and histopathological characteristics as well as complementary treatment received were also studied. Kaplan‑Meier and Cox regression analyses were performed. Data from 30 patients were retrieved, of which restaging with lymphadenectomy was performed in 21 patients (group 1), while another 9 patients (group 2) were not restaged and received complementary therapy. Lymph node metastasis was observed in 23.8% of patients in group 1 (n=5). No significant difference was observed between groups 1 and 2 in terms of survival outcomes. The median overall survival was 91.31 months in group 1 and 90.61 months in group 2 [hazard ratio (HR), 0.71; 95% CI, 0.03‑16.58; P=0.829]. The median disease‑free survival was 87.95 months in group 1 and 81.52 months in group 2 (HR, 0.85; 95% CI, 0.12‑5.91; P=0.869). In conclusion, restaging with lymphadenectomy did not alter prognosis of early‑stage, LVSI‑positive patients. As there was no clinical and therapeutic benefit, restaging with lymphadenectomy could be omitted in such patients.
View Figures

Figure 1

Figure 2

View References

1 

Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J, Marth C, Nout R, Querleu D, Mirza MR, et al: ESMO-ESGO-ESTRO consensus conference on endometrial cancer: Diagnosis, treatment and follow-up. Int J Gynecol Cancer. 26:2–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Jorge S, Hou JY, Tergas AI, Burke WM, Huang Y, Hu JC, Ananth CV, Neugut AI, Hershman DL and Wright JD: Magnitude of risk for nodal metastasis associated with lymphvascular space invasion for endometrial cancer. Gynecol Oncol. 140:387–393. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Wakayama A, Kudaka W, Matsumoto H, Aoyama H, Ooyama T, Taira Y, Arakaki Y, Shimoji Y, Nakasone T, Nishihira K, et al: Lymphatic vessel involvement is predictive for lymph node metastasis and an important prognostic factor in endometrial cancer. Int J Clin Oncol. 23:532–538. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Cohn DE, Horowitz NS, Mutch DG, Kim SM, Manolitsas T and Fowler JM: Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer? Gynecol Oncol. 87:243–246. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Chang SJ, Kong TW, Kim WY, Yoo SC, Yoon JH, Chang KH and Ryu HS: Lymph-vascular space invasion as a significant risk factor for isolated para-aortic lymph node metastasis in endometrial cancer: A study of 203 consecutive patients. Ann Surg Oncol. 18:58–64. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Briët JM, Hollema H, Reesink N, Aalders JG, Mourits MJE, Ten Hoor KA, Pras E, Boezen HM, van der Zee AG and Nijman HW: Lymphvascular space involvement: An independent prognostic factor in endometrial cancer. Gynecol Oncol. 96:799–804. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Sari ME, Yalcin İ, Sahin H, Meydanli MM and Gungor T: Risk factors for paraaortic lymph node metastasis in endometrial cancer. Int J Clin Oncol. 22:937–944. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Vaizoglu F, Yuce K, Salman MC, Basaran D, Calis P, Ozgul N and Usubutun A: Lymphovascular space involvement is the sole independent predictor of lymph node metastasis in clinical early stage endometrial cancer. Arch Gynecol Obstet. 288:1391–1397. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Zhang C, Wang C and Feng W: Clinicopathological risk factors for pelvic lymph node metastasis in clinical early-stage endometrioid endometrial adenocarcinoma. Int J Gynecol Cancer. 22:1373–1377. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Borghesi Y, Narducci F, Bresson L, Tresch E, Meurant JP, Cousin S, Cordoba A, Merlot B and Leblanc E: Managing endometrial cancer: The role of pelvic lymphadenectomy and secondary surgery. Ann Surg Oncol. 22 (Suppl 3):S936–S943. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Scioscia M, Noventa M and Laganà AS: Abnormal uterine bleeding and the risk of endometrial cancer: Can subendometrial vascular ultrasound be of help to discriminate cancer from adenomyosis. Am J Obstet Gynecol. 223:605–606. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Laganà AS and Scioscia M: Endometrial cancer in women with adenomyosis: An underestimated risk? Int J Fertil Steril. 14:260–261. 2020.PubMed/NCBI

13 

Concin N, Matias-Guiu X, Vergote I, Cibula D, Mirza MR, Marnitz S, Ledermann J, Bosse T, Chargari C, Fagotti A, et al: ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma. Int J Gynecol Cancer. 31:12–39. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Harris KL, Maurer KA, Jarboe E, Werner TL and Gaffney D: LVSI positive and NX in early endometrial cancer: Surgical restaging (and no further treatment if N0), or adjuvant ERT? Gynecol Oncol. 156:243–250. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Abu-Rustum NR, Yashar CM, Bradley K, Campos SM, Chino J, Chon HS, Chu C, Cohn D, Crispens MA, Damast S, et al: NCCN guidelines® insights: Uterine neoplasms, version 3.2021. J Natl Compr Canc Netw. 19:888–895. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Cardosi RJ, Cox CS and Hoffman MS: Postoperative neuropathies after major pelvic surgery. Obstet Gynecol. 100:240–244. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Volpi L, Sozzi G, Capozzi VA, Ricco M, Merisio C, Di Serio M, Chiantera V and Berretta R: Long term complications following pelvic and para-aortic lymphadenectomy for endometrial cancer, incidence and potential risk factors: A single institution experience. Int J Gynecol Cancer. 29:312–319. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Cusano E, Myers V, Samant R, Sudai T, Keller A, Le T, E C, Grimes S and Xu Y: Prognostic significance of lymphovascular space invasion in the absence of lymph node metastases in early-stage endometrial cancer. Int J Gynecol Cancer. 28:890–894. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Loizzi V, Cormio G, Lorusso M, Latorre D, Falagario M, Demitri P, Scardigno D and Selvaggi LE: The impact of lymph vascular space invasion on recurrence and survival in patients with early stage endometrial cancer. Eur J Cancer Care (Engl). 23:380–384. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Bosse T, Peters EEM, Creutzberg CL, Jürgenliemk-Schulz IM, Jobsen JJ, Mens JWM, Lutgens LCHW, van der Steen-Banasik EM, Smit VTHBM and Nout RA: Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer-a pooled analysis of PORTEC 1 and 2 trials. Eur J Cancer. 51:1742–1750. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Cignini P, Vitale SG, Laganà AS, Biondi A, Valentina Lucia La Rosa VL and Cutillo G: Preoperative work-up for definition of lymph node risk involvement in early stage endometrial cancer: 5-year follow-up. Updates Surg. 69:75–82. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Navarro B, Margioula-Siarkou C, Petousis S, Floquet A, Babin G and Guyon F: Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes. Oncol Lett 25: 122, 2023.
APA
Navarro, B., Margioula-Siarkou, C., Petousis, S., Floquet, A., Babin, G., & Guyon, F. (2023). Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes. Oncology Letters, 25, 122. https://doi.org/10.3892/ol.2023.13708
MLA
Navarro, B., Margioula-Siarkou, C., Petousis, S., Floquet, A., Babin, G., Guyon, F."Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes". Oncology Letters 25.3 (2023): 122.
Chicago
Navarro, B., Margioula-Siarkou, C., Petousis, S., Floquet, A., Babin, G., Guyon, F."Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes". Oncology Letters 25, no. 3 (2023): 122. https://doi.org/10.3892/ol.2023.13708
Copy and paste a formatted citation
x
Spandidos Publications style
Navarro B, Margioula-Siarkou C, Petousis S, Floquet A, Babin G and Guyon F: Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes. Oncol Lett 25: 122, 2023.
APA
Navarro, B., Margioula-Siarkou, C., Petousis, S., Floquet, A., Babin, G., & Guyon, F. (2023). Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes. Oncology Letters, 25, 122. https://doi.org/10.3892/ol.2023.13708
MLA
Navarro, B., Margioula-Siarkou, C., Petousis, S., Floquet, A., Babin, G., Guyon, F."Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes". Oncology Letters 25.3 (2023): 122.
Chicago
Navarro, B., Margioula-Siarkou, C., Petousis, S., Floquet, A., Babin, G., Guyon, F."Surgical restaging of patients with early‑stage endometrial cancer with lymphovascular invasion does not significantly impact their survival outcomes". Oncology Letters 25, no. 3 (2023): 122. https://doi.org/10.3892/ol.2023.13708
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team