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Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection

  • Authors:
    • Yikai Wang
    • Xinyu Bi
    • Hong Zhao
    • Zhiyu Li
    • Jianjun Zhao
    • Jianguo Zhou
    • Zhen Huang
    • Yefan Zhang
    • Xiao Chen
    • Chongda Zhang
    • Jianqiang Cai
    • Yijun Ren
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China, New York University Medical Center, New York University, New York, NY 10016, USA
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 147
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    Published online on: March 1, 2023
       https://doi.org/10.3892/ol.2023.13733
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Abstract

This study aimed to investigate the prognostic value of the preoperative alkaline phosphatase‑to‑albumin ratio (APAR) in patients with hepatocellular carcinoma (HCC) who underwent radical hepatectomy. The clinicopathological data from 330 patients was retrospectively analyzed. Receiver operating characteristic curves of APAR for diagnostic tumor recurrence were plotted with a cut‑off value of 1.74. A high preoperative APAR value was significantly associated with hepatitis B surface antigen level, tumor diameter, and tumor‑node‑metastasis stage. The disease‑free survival (DFS) and overall survival (OS) of patients with a high preoperative APAR were shorter than those with a low APAR. The independent risk factors for DFS were an APAR ≥1.74, and macrovascular invasion or tumor thrombus. The independent risk factors for OS were an APAR ≥1.74, existing clinical symptoms, α‑fetoprotein level ≥20 ng/ml, macrovascular invasion or tumor thrombus, and family history of cancer. In conclusion, a preoperative APAR (≥1.74) is an independent risk factor influencing the poor prognosis of patients with HCC after curative hepatectomy, and patients with such a result should be closely monitored.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Bi X, Zhao H, Li Z, Zhao J, Zhou J, Huang Z, Zhang Y, Chen X, Zhang C, Zhang C, et al: Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection. Oncol Lett 25: 147, 2023.
APA
Wang, Y., Bi, X., Zhao, H., Li, Z., Zhao, J., Zhou, J. ... Ren, Y. (2023). Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection. Oncology Letters, 25, 147. https://doi.org/10.3892/ol.2023.13733
MLA
Wang, Y., Bi, X., Zhao, H., Li, Z., Zhao, J., Zhou, J., Huang, Z., Zhang, Y., Chen, X., Zhang, C., Cai, J., Ren, Y."Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection". Oncology Letters 25.4 (2023): 147.
Chicago
Wang, Y., Bi, X., Zhao, H., Li, Z., Zhao, J., Zhou, J., Huang, Z., Zhang, Y., Chen, X., Zhang, C., Cai, J., Ren, Y."Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection". Oncology Letters 25, no. 4 (2023): 147. https://doi.org/10.3892/ol.2023.13733
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Bi X, Zhao H, Li Z, Zhao J, Zhou J, Huang Z, Zhang Y, Chen X, Zhang C, Zhang C, et al: Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection. Oncol Lett 25: 147, 2023.
APA
Wang, Y., Bi, X., Zhao, H., Li, Z., Zhao, J., Zhou, J. ... Ren, Y. (2023). Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection. Oncology Letters, 25, 147. https://doi.org/10.3892/ol.2023.13733
MLA
Wang, Y., Bi, X., Zhao, H., Li, Z., Zhao, J., Zhou, J., Huang, Z., Zhang, Y., Chen, X., Zhang, C., Cai, J., Ren, Y."Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection". Oncology Letters 25.4 (2023): 147.
Chicago
Wang, Y., Bi, X., Zhao, H., Li, Z., Zhao, J., Zhou, J., Huang, Z., Zhang, Y., Chen, X., Zhang, C., Cai, J., Ren, Y."Prognostic significance of the preoperative alkaline phosphatase‑to‑albumin ratio in patients with hepatocellular carcinoma after hepatic resection". Oncology Letters 25, no. 4 (2023): 147. https://doi.org/10.3892/ol.2023.13733
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