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Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses

  • Authors:
    • Wenfeng Yu
    • Honghai Ma
    • Guocan Yu
    • Pinghui Xia
    • Zhou An
    • Li Yu
    • Wang Lv
    • Bo Ye
    • Jian Hu

  • View Affiliations

  • Published online on: March 8, 2023     https://doi.org/10.3892/ol.2023.13751
  • Article Number: 166

  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to explore the final diagnosis of pulmonary nodules with an initial non‑diagnostic result on electromagnetic navigation bronchoscopy (ENB) biopsy and the predictive factors for a non‑diagnostic result. A total of 198 nodules from 194 patients that were suspected to be malignant tumors were included in the present study. The initial biopsy pathology results were divided into two groups: The diagnostic group and the non‑diagnostic group. The diagnostic group was defined as a successful initial biopsy to obtain a diagnosis, including malignant and benign diagnoses. The non‑diagnostic group was defined as a non‑specific benign diagnosis, normal lung tissue or an unsuccessful biopsy. Among the 198 nodules, 139 (70.2%) were in the diagnostic group and 59 (29.8%) were in the non‑diagnostic group. Predictive factors for a non‑diagnostic biopsy included nodule size ≤1.5 cm [odds ratio (OR), 2.05; 95% confidence interval (CI), 1.03‑4.09], non‑solid nodules (OR, 2.71; 95% CI, 1.33‑5.64) and nodules in the left lung (OR, 2.50; 95% CI, 1.27‑4.92). Of the 59 non‑diagnostic biopsies, 46 were finally confirmed to be malignant by surgery. Notably, non‑diagnostic biopsies with non‑solid nodules (OR, 7.64; 95% CI, 3.11‑18.76) were more likely to be malignant. In conclusion, the predictive factors for a non‑diagnostic biopsy were nodule size ≤1.5 cm and non‑solid nodules. It was not rare for patients to finally be diagnosed with a malignancy in the non‑diagnostic group. Therefore, care should be taken when the results of an ENB are non‑diagnostic to prevent misdiagnosis.
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April-2023
Volume 25 Issue 4

Print ISSN: 1792-1074
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Spandidos Publications style
Yu W, Ma H, Yu G, Xia P, An Z, Yu L, Lv W, Ye B and Hu J: Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses. Oncol Lett 25: 166, 2023
APA
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L. ... Hu, J. (2023). Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses. Oncology Letters, 25, 166. https://doi.org/10.3892/ol.2023.13751
MLA
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L., Lv, W., Ye, B., Hu, J."Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses". Oncology Letters 25.4 (2023): 166.
Chicago
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L., Lv, W., Ye, B., Hu, J."Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses". Oncology Letters 25, no. 4 (2023): 166. https://doi.org/10.3892/ol.2023.13751