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Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses

  • Authors:
    • Wenfeng Yu
    • Honghai Ma
    • Guocan Yu
    • Pinghui Xia
    • Zhou An
    • Li Yu
    • Wang Lv
    • Bo Ye
    • Jian Hu
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P.R. China, Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China, Department of Thoracic Surgery, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 166
    |
    Published online on: March 8, 2023
       https://doi.org/10.3892/ol.2023.13751
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Abstract

The present study aimed to explore the final diagnosis of pulmonary nodules with an initial non‑diagnostic result on electromagnetic navigation bronchoscopy (ENB) biopsy and the predictive factors for a non‑diagnostic result. A total of 198 nodules from 194 patients that were suspected to be malignant tumors were included in the present study. The initial biopsy pathology results were divided into two groups: The diagnostic group and the non‑diagnostic group. The diagnostic group was defined as a successful initial biopsy to obtain a diagnosis, including malignant and benign diagnoses. The non‑diagnostic group was defined as a non‑specific benign diagnosis, normal lung tissue or an unsuccessful biopsy. Among the 198 nodules, 139 (70.2%) were in the diagnostic group and 59 (29.8%) were in the non‑diagnostic group. Predictive factors for a non‑diagnostic biopsy included nodule size ≤1.5 cm [odds ratio (OR), 2.05; 95% confidence interval (CI), 1.03‑4.09], non‑solid nodules (OR, 2.71; 95% CI, 1.33‑5.64) and nodules in the left lung (OR, 2.50; 95% CI, 1.27‑4.92). Of the 59 non‑diagnostic biopsies, 46 were finally confirmed to be malignant by surgery. Notably, non‑diagnostic biopsies with non‑solid nodules (OR, 7.64; 95% CI, 3.11‑18.76) were more likely to be malignant. In conclusion, the predictive factors for a non‑diagnostic biopsy were nodule size ≤1.5 cm and non‑solid nodules. It was not rare for patients to finally be diagnosed with a malignancy in the non‑diagnostic group. Therefore, care should be taken when the results of an ENB are non‑diagnostic to prevent misdiagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Yu W, Ma H, Yu G, Xia P, An Z, Yu L, Lv W, Ye B and Hu J: Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses. Oncol Lett 25: 166, 2023.
APA
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L. ... Hu, J. (2023). Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses. Oncology Letters, 25, 166. https://doi.org/10.3892/ol.2023.13751
MLA
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L., Lv, W., Ye, B., Hu, J."Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses". Oncology Letters 25.4 (2023): 166.
Chicago
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L., Lv, W., Ye, B., Hu, J."Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses". Oncology Letters 25, no. 4 (2023): 166. https://doi.org/10.3892/ol.2023.13751
Copy and paste a formatted citation
x
Spandidos Publications style
Yu W, Ma H, Yu G, Xia P, An Z, Yu L, Lv W, Ye B and Hu J: Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses. Oncol Lett 25: 166, 2023.
APA
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L. ... Hu, J. (2023). Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses. Oncology Letters, 25, 166. https://doi.org/10.3892/ol.2023.13751
MLA
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L., Lv, W., Ye, B., Hu, J."Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses". Oncology Letters 25.4 (2023): 166.
Chicago
Yu, W., Ma, H., Yu, G., Xia, P., An, Z., Yu, L., Lv, W., Ye, B., Hu, J."Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses". Oncology Letters 25, no. 4 (2023): 166. https://doi.org/10.3892/ol.2023.13751
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