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Article Open Access

LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma

  • Authors:
    • Yohei Kawasaki
    • Hitomi Suzuki
    • Masahito Miura
    • Haruka Hatakeyama
    • Shinsuke Suzuki
    • Takechiyo Yamada
    • Maya Suzuki
    • Ayumi Ito
    • Yasufumi Omori
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology and Head‑and‑Neck Surgery, Akita University Graduate School of Medicine, Akita, Akita 010‑8543, Japan, Department of Molecular and Tumour Pathology, Akita University Graduate School of Medicine, Akita, Akita 010‑8543, Japan
    Copyright: © Kawasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 171
    |
    Published online on: March 13, 2023
       https://doi.org/10.3892/ol.2023.13757
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Abstract

Head and neck squamous cell carcinoma (HNSCC) has been identified as the sixth most common disease in the world, and its prognosis remains poor. The basic treatment of HNSCC includes a combination of chemoradiation and surgery. With the advent of immune checkpoint inhibitors, the prognosis has improved; however, the efficacy of checkpoint inhibitors is limited. L‑type amino acid transporter 1 (LAT1), an amino acid transporter, is highly expressed in a cancer‑specific manner. However, to the best of our knowledge, LAT1 expression in HNSCC has not been determined. Therefore, the present study aimed to examine the role of LAT1 expression in HNSCC. A total of three HNSCC cell lines (Sa3, HSC2 and HSC4) were used to investigate the characteristics of LAT1‑positive cells, including their ability to form spheroids, and their invasion and migration. The present study also examined LAT1 by immunostaining of biopsy specimens from 174 patients diagnosed, treated and followed‑up at Akita University (Akita, Japan) between January 2010 and December 2019, and overall survival, progression‑free survival and multivariate analyses were performed. The results demonstrated that LAT1‑positive cells in HNSCC were an independent prognostic factor for overall survival and progression‑free survival, and were resistant to chemoradiation. Therefore, JPH203, a LAT1 inhibitor, may be effective in treating chemoradiotherapy‑resistant HNSCC and may improve the prognosis of patients with HNSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Kawasaki Y, Suzuki H, Miura M, Hatakeyama H, Suzuki S, Yamada T, Suzuki M, Ito A and Omori Y: LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma. Oncol Lett 25: 171, 2023.
APA
Kawasaki, Y., Suzuki, H., Miura, M., Hatakeyama, H., Suzuki, S., Yamada, T. ... Omori, Y. (2023). LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma. Oncology Letters, 25, 171. https://doi.org/10.3892/ol.2023.13757
MLA
Kawasaki, Y., Suzuki, H., Miura, M., Hatakeyama, H., Suzuki, S., Yamada, T., Suzuki, M., Ito, A., Omori, Y."LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma". Oncology Letters 25.4 (2023): 171.
Chicago
Kawasaki, Y., Suzuki, H., Miura, M., Hatakeyama, H., Suzuki, S., Yamada, T., Suzuki, M., Ito, A., Omori, Y."LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma". Oncology Letters 25, no. 4 (2023): 171. https://doi.org/10.3892/ol.2023.13757
Copy and paste a formatted citation
x
Spandidos Publications style
Kawasaki Y, Suzuki H, Miura M, Hatakeyama H, Suzuki S, Yamada T, Suzuki M, Ito A and Omori Y: LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma. Oncol Lett 25: 171, 2023.
APA
Kawasaki, Y., Suzuki, H., Miura, M., Hatakeyama, H., Suzuki, S., Yamada, T. ... Omori, Y. (2023). LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma. Oncology Letters, 25, 171. https://doi.org/10.3892/ol.2023.13757
MLA
Kawasaki, Y., Suzuki, H., Miura, M., Hatakeyama, H., Suzuki, S., Yamada, T., Suzuki, M., Ito, A., Omori, Y."LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma". Oncology Letters 25.4 (2023): 171.
Chicago
Kawasaki, Y., Suzuki, H., Miura, M., Hatakeyama, H., Suzuki, S., Yamada, T., Suzuki, M., Ito, A., Omori, Y."LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma". Oncology Letters 25, no. 4 (2023): 171. https://doi.org/10.3892/ol.2023.13757
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