Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2023 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2023 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Primary hepatic paraganglioma with megacolon: A case report

  • Authors:
    • Jin-Peng Bo
    • Nan Zhou
    • Meng-Xue Sun
    • Jian Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China, Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China
    Copyright: © Bo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 183
    |
    Published online on: March 22, 2023
       https://doi.org/10.3892/ol.2023.13769
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Primary hepatic paraganglioma (PGL) is a rare neuroendocrine tumor characterized by clinical manifestations including paroxysmal hypertension, palpitation, abdominal pain and constipation. In the present study, the case of a 21‑year‑old woman with pathologically confirmed hepatic PGL with megacolon following surgery is reported. The patient initially visited Beijing Tiantan Hospital (Beijing, China) for hypoferric anemia. A triple‑phase CT scan of the whole abdomen showed a large hypodense mass with a solid periphery and strong arterial enhancement of the peripheral solid portion of the liver. The sigmoid colon and rectum were obviously distended, filled with gas and intestinal contents. The patient was preoperatively diagnosed with iron deficiency anemia, liver injury and megacolon and then underwent partial hepatectomy, total colectomy and enterostomy. Microscopically, the liver cells exhibited an irregular zellballen pattern. In addition, immunohistochemical staining revealed that liver cells were positive for CD56, chromogranin A, vimentin, S‑100, melan‑A and neuron‑specific enolase. Therefore, the diagnosis of primary PGL of the liver was confirmed. These findings suggested that primary hepatic PGL should not be excluded when megacolon occurs and comprehensive imaging evaluation is of great importance for its diagnosis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Lloyd RV, Osamura YR, Kloppel G and Rosa J: WHO classification of tumours of endocrine organs. WHO Classification of Tumours. 10. 4th edition. World Health Organization; Geneva: 2017

2 

Liao W, Ding ZY, Zhang B, Chen L, Li GX, Wu JJ, Zhang B, Chen XP and Zhu P: Primary functioning hepatic paraganglioma mimicking hepatocellular carcinoma: A case report and literature review. Medicine (Baltimore). 97:e02932018. View Article : Google Scholar : PubMed/NCBI

3 

Thosani S, Ayala-Ramirez M, Román-González A, Zhou S, Thosani N, Bisanz A and Jimenez C: Constipation: an overlooked, unmanaged symptom of patients with pheochromocytoma and sympathetic paraganglioma. Eur J Endocrinol. 173:377–387. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Corti B, D'Errico A, Pierangeli F, Fiorentino M, Altimari A and Grigioni WF: Primary paraganglioma strictly confined to the liver and mimicking hepatocellular carcinoma: An immunohistochemical and in situ hybridization study. Am J Surg Pathol. 26:945–949. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Khan MR, Raza R, Jabbar A and Ahmed A: Primary non-functioning paraganglioma of liver: A rare tumour at an unusual location. J Pak Med Assoc. 6:814–816. 2011.PubMed/NCBI

6 

Lin CS and Hsu YH: A primary paraganglioma of the liver mimicking hepatocellular carcinoma. Ci Ji Yi Xue Za Zhi. 31:286–288. 2019.PubMed/NCBI

7 

Vella I, De Carlis R, Lauterio A and De Carlis L: Extremely rare presentation of primary nonfunctioning hepatic paraganglioma. Dig Liver Dis. 54:838–839. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Bachmeier CAE, Haque M, Barrett HL and Morton A: Hepatic paraganglioma hiding as a slowly growing lesion for 24 years: A diagnostic conundrum. BMJ Case Rep. 12:e2289472019. View Article : Google Scholar : PubMed/NCBI

9 

Koh PS, Koong JK, Westerhout CJ and Yoong BK: Education and imaging. Hepatobiliary and pancreatic: A huge liver paraganglioma. J Gastroenterol Hepatol. 28:10752013. View Article : Google Scholar : PubMed/NCBI

10 

Miller ME, Vietor NO, Park EJ, Sweeney SP, Katz M and Vietor RC: Paraganglioma masquerading as a primary liver lesion: A rare entity discovered during surgery. Clin Case Rep. 10:e053102022. View Article : Google Scholar : PubMed/NCBI

11 

Chang H, Xu L and Mu Q: Primary functioning hepatic paraganglioma: A case report. Adv Ther. 23:817–820. 2006. View Article : Google Scholar : PubMed/NCBI

12 

You Z, Deng Y, Shrestha A, Li F and Cheng N: Primary malignant hepatic paraganglioma mimicking liver tumor: A case report. Oncol Lett. 10:1176–1178. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Corssmit EP and Romijn JA: Clinical management of paragangliomas. Eur J Endocrinol. 171:R231–R243. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Gunawardane PTK and Grossman A: Phaeochromocytoma and paraganglioma. Adv Exp Med Biol. 956:239–259. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Szakacs JE and Cannon A: L-Norepinephrine myocarditis. Am J Clin Pathol. 30:425–434. 1958. View Article : Google Scholar : PubMed/NCBI

16 

Sweeney AT, Malabanan AO, Blake MA, de las Morenas A, Cachecho R and Melby JC: Megacolon as the presenting feature in pheochromocytoma. J Clin Endocrinol Metab. 85:3968–3972. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Carrasquillo JA, Chen CC, Jha A, Ling A, Lin FI, Pryma DA and Pacak K: Imaging of pheochromocytoma and paraganglioma. J Nucl Med. 62:1033–1042. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Baez JC, Jagannathan JP, Krajewski K, O'Regan K, Zukotynski K and Ramaiya NH: Pheochromocytoma and paraganglioma: Imaging characteristics. Cancer Imaging. 12:153–162. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Jain A, Baracco R and Kapur G: Pheochromocytoma and paraganglioma-an update on diagnosis, evaluation, and management. Pediatr Nephrol. 35:581–594. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Tanaka S, Ito T, Tomoda J, Higashi T, Yamada G and Tsuji T: Malignant pheochromocytoma with hepatic metastasis diagnosed 20 years after resection of the primary adrenal lesion. Intern Med. 32:789–794. 1993. View Article : Google Scholar : PubMed/NCBI

21 

Crona J, Taïeb D and Pacak K: New perspectives on pheochromocytoma and paraganglioma: Toward a molecular classification. Endocr Rev. 38:489–515. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Fishbein L: Pheochromocytoma and paraganglioma: Genetics, diagnosis, and treatment. Hematol Oncol Clin North Am. 30:135–150. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Neumann HPH, Young WF Jr and Eng C: Pheochromocytoma and paraganglioma. N Engl J Med. 381:552–565. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Karimi P, Islami F, Anandasabapathy S, Freedman ND and Kamangar F: Gastric cancer: Descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 23:700–713. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bo J, Zhou N, Sun M and Zhou J: Primary hepatic paraganglioma with megacolon: A case report. Oncol Lett 25: 183, 2023.
APA
Bo, J., Zhou, N., Sun, M., & Zhou, J. (2023). Primary hepatic paraganglioma with megacolon: A case report. Oncology Letters, 25, 183. https://doi.org/10.3892/ol.2023.13769
MLA
Bo, J., Zhou, N., Sun, M., Zhou, J."Primary hepatic paraganglioma with megacolon: A case report". Oncology Letters 25.5 (2023): 183.
Chicago
Bo, J., Zhou, N., Sun, M., Zhou, J."Primary hepatic paraganglioma with megacolon: A case report". Oncology Letters 25, no. 5 (2023): 183. https://doi.org/10.3892/ol.2023.13769
Copy and paste a formatted citation
x
Spandidos Publications style
Bo J, Zhou N, Sun M and Zhou J: Primary hepatic paraganglioma with megacolon: A case report. Oncol Lett 25: 183, 2023.
APA
Bo, J., Zhou, N., Sun, M., & Zhou, J. (2023). Primary hepatic paraganglioma with megacolon: A case report. Oncology Letters, 25, 183. https://doi.org/10.3892/ol.2023.13769
MLA
Bo, J., Zhou, N., Sun, M., Zhou, J."Primary hepatic paraganglioma with megacolon: A case report". Oncology Letters 25.5 (2023): 183.
Chicago
Bo, J., Zhou, N., Sun, M., Zhou, J."Primary hepatic paraganglioma with megacolon: A case report". Oncology Letters 25, no. 5 (2023): 183. https://doi.org/10.3892/ol.2023.13769
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team