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Clinical significance of the KRAS G13D mutation in anastomotic recurrence of colorectal cancer

  • Authors:
    • Keigo Matsunaga
    • Kazuhito Sasaki
    • Keisuke Hata
    • Hiroaki Nozawa
    • Kazushige Kawai
    • Koji Murono
    • Shigenobu Emoto
    • Yuichiro Yokoyama
    • Hirofumi Sonoda
    • Koji Ueda
    • Sho Kuriyama
    • Takeshi Yamada
    • Hiroshi Yoshida
    • Soichiro Ishihara
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan, Nihonbashi Muromachi Mitsui Tower Midtown Clinic, Tokyo 103-0022, Japan, Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo 113-8677, Japan, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo 113-8602, Japan
    Copyright: © Matsunaga et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 192
    |
    Published online on: March 28, 2023
       https://doi.org/10.3892/ol.2023.13778
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Abstract

The genetic risk factors for anastomotic recurrence (AR) after curative surgery for colorectal cancer (CRC) are unclear. The present study is a single‑center retrospective observational study that aimed to elucidate the association between the KRAS G13D mutation and AR in CRC. The present study included 21 patients with AR and 67 patients with non‑anastomotic local recurrence (NALR) following curative surgery for CRC between January 2005 and December 2019. KRAS G13D mutation status was examined by droplet digital polymerase chain reaction. Data of clinicopathological findings and oncological outcomes were analyzed and compared between the AR group and the matched NALR group. The prevalence of the KRAS G13D mutation was significantly higher in the AR group (AR vs. NALR, 33.3 vs. 4.8%; P=0.047). Comparing the KRAS G13D mutation‑positive and KRAS G13D mutation‑negative patients in the AR group, there was no significant difference in the time from initial surgery to AR or resection rate of AR; however, all patients with KRAS G13D mutation who underwent resection of AR had subsequent recurrence within 2 years after resection, and overall survival was poor (3‑year survival rate: Positive vs. negative, 68.6 vs. 90.9%; P=0.02). The prevalence of the KRAS G13D mutation was significantly higher in patients with AR, and KRAS G13D‑mutant patients with AR had a poorer prognosis than those that were negative for the KRAS G13D mutation. In conclusion, postoperative surveillance and treatment strategies should be considered with attention to the possibility of AR and subsequent recurrence in KRAS G13D‑mutant patients.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Böhm B, Schwenk W, Hucke HP and Stock W: Does methodic long-term follow-up affect survival after curative resection of colorectal carcinoma? Dis Colon Rectum. 36:280–286. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Jung WB, Yu CS, Lim SB, Park IJ, Yoon YS and Kim JC: Anastomotic recurrence after curative resection for colorectal cancer. World J Surg. 41:285–294. 2017. View Article : Google Scholar : PubMed/NCBI

4 

McGregor JR, Galloway DJ, McCulloch P and George WD: Anastomotic suture materials and implantation metastasis: An experimental study. Br J Surg. 76:331–334. 1989. View Article : Google Scholar : PubMed/NCBI

5 

Costi R, Santi C, Bottarelli L, Azzoni C, Le Bian AZ, Ricco M, Sarli L, Silini EM and Violi V: Anastomotic recurrence of colon cancer: Genetic analysis challenges the widely held theories of cancerous cells' intraluminal implantation and metachronous carcinogenesis. J Surg Oncol. 114:228–236. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Vakiani E, Shah RH, Berger MF, Makohon-Moore AP, Reiter JG, Ostrovnaya I, Attiyeh MA, Cercek A, Shia J, Lacobuzio-Donahue CA, et al: Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma. Oncotarget. 8:42487–42494. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Okada S, Hata K, Kawai K, Yamomoto Y, Tanaka T, Nishikawa T, Sasaki K, Kaneko M, Emoto S, Murono K and Nozawa H: Association between KRAS G13D mutations and anastomotic recurrence in colorectal cancer: Two case reports. Medicine (Baltimore). 98:e147812019. View Article : Google Scholar : PubMed/NCBI

8 

Brierley JD, Gospodarowicz MK and Wittekind C: UICC TNM classification of malignant tumours. 8th edition. Wiley-Blackwell; Oxford: 2017

9 

Do H and Dobrovic A: Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase. Oncotarget. 3:546–558. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Andreyev HJ, Norman AR, Cunningham D, Oates JR and Clarke PA: Kirsten ras mutations in patients with colorectal cancer: The multicenter ‘RASCAL’ study. J Natl Cancer Inst. 90:675–684. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Roth AD, Tejpar S, Delorenzi M, Yah P, Fiocca R, Klingbiel D, Dietrich D, Biesmans B, Bodoky G, Barone C, et al: Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol. 28:466–474. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Hinoi T: Cancer genomic profiling in colorectal cancer: Current challenges in subtyping colorectal cancers based on somatic and germline variants. J Anus Rectum Colon. 5:213–228. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Watanabe T, Yoshino T, Uetake H, Yamazaki K, Ishiguro M, Kurokawa T, Saijo N, Ohashi Y and Sugihara K: KRAS mutational status in Japanese patients with colorectal cancer: Results from a nationwide, multicenter, cross-sectional study. Jpn J Clin Oncol. 43:706–712. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Kadowaki S, Kakuta M, Takahashi S, Takahashi A, Arai Y, Nishimura Y, Yatsuoka T, Ooki A, Yamaguchi K, Matsuo K, et al: Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer. World J Gastroenterol. 21:1275–1283. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Passiglia F, Bronte G, Bazan V, Galvano A, Vincenzi B and Russo A: Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis. Crit Rev Oncol Hematol. 99:150–157. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Inoue Y, Saigusa S, Iwata T, Okugawa Y, Toiyama Y, Tanaka K, Uchida K, Mohri Y and Kusunoki M: The prognostic value of KRAS mutations in patients with colorectal cancer. Oncol Rep. 28:1579–1584. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Bazan V, Migliavacca M, Zanna I, Tubiolo C, Grassi N, Latteri MA, La Farina M, Albanese I, Dardanoni G, Salerno S, et al: Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol. 13:1438–1446. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Hayama T, Hashiguchi Y, Okamoto K, Okada Y, Ono K, Shimada R, Ozawa T, Toyoda T, Tsuchiya T, Iinuma H, et al: G12V and G12C mutations in the gene KRAS are associated with a poorer prognosis in primary colorectal cancer. Int J Colorectal Dis. 34:1491–1496. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Imamura Y, Morikawa T, Liao X, Lochhead P, Kuchida A, Yamauchi M, Qian ZE, Nishihara R, Meyerhardt JA, Haigis KM, et al: Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers. Clin Cancer Res. 18:4753–4763. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Kodaz H, Hacibekiroglu I, Erdogan B, Turkmen E, Tozkir H, Albayrak D, Uzunoglu S and Cicin I: Association between specific KRAS mutations and the clinicopathological characteristics of colorectal tumors. Mol Clin Oncol. 3:179–184. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Organ SL, Hai J, Radulovich N, Marshall CB, Leung L, Sasazuki T, Shirasawa S, Zhu CQ, Navab R, Ikura M and Tsao MS: p120RasGAP is a mediator of rho pathway activation and tumorigenicity in the DLD1 colorectal cancer cell line. PLoS One. 9:e861032014. View Article : Google Scholar : PubMed/NCBI

23 

Stolze B, Reinhart S, Bulllinger L, Frohling S and Scholl C: Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines. Sci Rep. 5:85352015. View Article : Google Scholar : PubMed/NCBI

24 

Margonis GA, Kim Y, Sasaki K, Samaha M, Amini N and Pawlik TM: Codon 13 KRAS mutation predicts patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases. Cancer. 122:2698–2707. 2016. View Article : Google Scholar : PubMed/NCBI

25 

De Roock W, Jonker DJ, Di Nicolantonio F, Sartore-Bianchi A, Tu D, Siena S, Lamba S, Arena S, Frattini M, Piessevaux H, et al: Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA. 304:1812–1820. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Tejpar S, Celik I, Schlichting M, Sartorius U, Bokemeyer C and Van Cutsem E: Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. J Clin Oncol. 30:3570–3577. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Rowland A, Dias MM, Wiese MD, Kichenadasse G, McKinnon RA, Karapetis CS and Sorich MJ: Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours. Eur J Cancer. 55:122–130. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Matsunaga K, Sasaki K, Hata K, Nozawa H, Kawai K, Murono K, Emoto S, Yokoyama Y, Sonoda H, Ueda K, Ueda K, et al: Clinical significance of the <em>KRAS G13D</em> mutation in anastomotic recurrence of colorectal cancer. Oncol Lett 25: 192, 2023.
APA
Matsunaga, K., Sasaki, K., Hata, K., Nozawa, H., Kawai, K., Murono, K. ... Ishihara, S. (2023). Clinical significance of the <em>KRAS G13D</em> mutation in anastomotic recurrence of colorectal cancer. Oncology Letters, 25, 192. https://doi.org/10.3892/ol.2023.13778
MLA
Matsunaga, K., Sasaki, K., Hata, K., Nozawa, H., Kawai, K., Murono, K., Emoto, S., Yokoyama, Y., Sonoda, H., Ueda, K., Kuriyama, S., Yamada, T., Yoshida, H., Ishihara, S."Clinical significance of the <em>KRAS G13D</em> mutation in anastomotic recurrence of colorectal cancer". Oncology Letters 25.5 (2023): 192.
Chicago
Matsunaga, K., Sasaki, K., Hata, K., Nozawa, H., Kawai, K., Murono, K., Emoto, S., Yokoyama, Y., Sonoda, H., Ueda, K., Kuriyama, S., Yamada, T., Yoshida, H., Ishihara, S."Clinical significance of the <em>KRAS G13D</em> mutation in anastomotic recurrence of colorectal cancer". Oncology Letters 25, no. 5 (2023): 192. https://doi.org/10.3892/ol.2023.13778
Copy and paste a formatted citation
x
Spandidos Publications style
Matsunaga K, Sasaki K, Hata K, Nozawa H, Kawai K, Murono K, Emoto S, Yokoyama Y, Sonoda H, Ueda K, Ueda K, et al: Clinical significance of the <em>KRAS G13D</em> mutation in anastomotic recurrence of colorectal cancer. Oncol Lett 25: 192, 2023.
APA
Matsunaga, K., Sasaki, K., Hata, K., Nozawa, H., Kawai, K., Murono, K. ... Ishihara, S. (2023). Clinical significance of the <em>KRAS G13D</em> mutation in anastomotic recurrence of colorectal cancer. Oncology Letters, 25, 192. https://doi.org/10.3892/ol.2023.13778
MLA
Matsunaga, K., Sasaki, K., Hata, K., Nozawa, H., Kawai, K., Murono, K., Emoto, S., Yokoyama, Y., Sonoda, H., Ueda, K., Kuriyama, S., Yamada, T., Yoshida, H., Ishihara, S."Clinical significance of the <em>KRAS G13D</em> mutation in anastomotic recurrence of colorectal cancer". Oncology Letters 25.5 (2023): 192.
Chicago
Matsunaga, K., Sasaki, K., Hata, K., Nozawa, H., Kawai, K., Murono, K., Emoto, S., Yokoyama, Y., Sonoda, H., Ueda, K., Kuriyama, S., Yamada, T., Yoshida, H., Ishihara, S."Clinical significance of the <em>KRAS G13D</em> mutation in anastomotic recurrence of colorectal cancer". Oncology Letters 25, no. 5 (2023): 192. https://doi.org/10.3892/ol.2023.13778
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