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Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases

  • Authors:
    • Meiling Wang
    • Wei Zhang
    • Chunmei Fu
    • Jian Guan
    • Xiaoguang Ni
    • Fang Yao
  • View Affiliations / Copyright

    Affiliations: Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, P.R. China, Department of Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, P.R. China, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, P.R. China, Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100020, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 228
    |
    Published online on: April 13, 2023
       https://doi.org/10.3892/ol.2023.13814
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Abstract

Metastatic spread of lung adenocarcinoma to the stomach is rare and most gastric metastases are discovered at the advanced stage due to certain symptoms. The present study reported two cases of asymptomatic gastric metastases from lung adenocarcinoma presenting as diminutive nodules or erosion endoscopically. The manifestations were also visualized under magnifying endoscopy with blue laser imaging (BLI‑ME), the two cases share certain common characteristics under BLI‑ME, such as an obviously widened intervening part and extended subepithelial capillary network, which indicated that lesions developed beneath the superficial epithelium. Target biopsy and further immunohistochemical staining confirmed that the gastric lesions were metastatic from primary lung cancer. None of the two patients were candidates for surgery due to multiple distant metastases, but the gastric metastases regressed to scars after systemic anticancer therapy. These two cases were presented in order to improve the current understanding of the endoscopic manifestations of early gastric metastases from lung cancer, and the outcomes may demonstrate that systemic treatment is effective for eliminating early gastric metastatic lesions.
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1 

Cao M and Chen W: Epidemiology of lung cancer in China. Thorac Cancer. 10:3–7. 2019. View Article : Google Scholar : PubMed/NCBI

2 

McNeill PM, Wagman LD and Neifeld JP: Small bowel metastases from primary carcinoma of the lung. Cancer. 59:1486–1489. 1987. View Article : Google Scholar : PubMed/NCBI

3 

Taira N, Kawabata T, Gabe A, Furugen T, Ichi T, Kushi K, Yohena T, Kawasaki H, Higuchi D, Chibana K, et al: Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis. Oncol Lett. 14:2399–2404. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Lee PC, Lo C, Lin MT, Liang JT and Lin BR: Role of surgical intervention in managing gastrointestinal metastases from lung cancer. World J Gastroenterol. 17:4314–4320. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Oda Kondo H, Yamao T, Saito D, Ono H, Gotoda T, Yamaguchi H, Yoshida S and Shimoda T: Metastatic tumors to the stomach: Analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy. 33:507–510. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Altintas E, Sezgin O, Uyar B and Polat A: Acute upper gastrointestinal bleeding due to metastatic lung cancer: An unusual case. Yonsei Med J. 47:276–277. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Green LK: Hematogenous metastases to the stomach: A review of 67 cases. Cancer. 65:1596–1600. 1990. View Article : Google Scholar : PubMed/NCBI

8 

Kim MS, Kook EH, Ahn SH, Jeon SY, Yoon JH, Han MS, Kim CH and Lee JC: Gastrointestinal metastasis of lung cancer with special emphasis on a long-term survivor after operation. J Cancer Res Clin Oncol. 135:297–301. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Yang CJ, Hwang JJ, Kang WY, Chong IW, Wang TH, Sheu CC, Tsai JR and Huang MS: Gastro-intestinal metastasis of primary lung carcinoma: Clinical presentations and outcome. Lung Cancer. 54:319–323. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Duan X, Zhao X and Wang S: An ALK-positive lung adenocarcinoma with gastric and skin metastasis: A case report and literature review. Ann Palliat Med. 10:5797–5807. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Nitipir C, Ginghina O, Popa L, Andrei F, Tudor N, Radu I, Iaciu C, Orlov C, Vasilescu F, Balalau C, et al: A rare case of advanced lung cancer presenting as a symptomatic gastric tumor. Mol Clin Oncol. 8:595–599. 2018.PubMed/NCBI

12 

Tang D, Lv J, Liu Z, Zhan S and Gao Y: Gastric metastasis of primary lung cancer: Case report and systematic review with pooled analysis. Front Oncol. 12:9220162022. View Article : Google Scholar : PubMed/NCBI

13 

De Palma GD, Masone S, Rega M, Simeoli I, Donisi M, Addeo P, Iannone L, Pilone V and Persico G: Metastatic tumors to the stomach: Clinical and endoscopic features. World J Gastroenterol. 12:7326–7328. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Qasrawi A, Abu Ghanimeh M, Albadarin S and Yousef O: Gastric metastases from lung adenocarcinoma causing gastrointestinal bleeding. ACG Case Rep J. 4:e252017. View Article : Google Scholar : PubMed/NCBI

15 

Okazaki R, Ohtani H, Takeda K, Sumikawa T, Yamasaki A, Matsumoto S and Shimizu E: Gastric metastasis by primary lung adenocarcinoma. World J Gastrointest Oncol. 2:395–398. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Maeda J, Miyake M, Tokita K, Iwahashi N, Nakano T, Tamura S, Hada T and Higashino K: Small cell lung cancer with extensive cutaneous and gastric metastases. Intern Med. 31:1325–1328. 1992. View Article : Google Scholar : PubMed/NCBI

17 

Standards of Practice Committee, . Faulx AL, Kothari S, Acosta RD, Agrawal D, Bruining DH, Chandrasekhara V, Eloubeidi MA, Fanelli RD, Gurudu SR, et al: The role of endoscopy in subepithelial lesions of the GI tract. Gastrointest Endosc. 85:1117–1132. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Sileri P, D'Ugo S, Del Vecchio Blanco G, Lolli E, Franceschilli L, Formica V, Anemona L, De Luca C and Gaspari AL: Solitary metachronous gastric metastasis from pulmonary adenocarcinoma: Report of a case. Int J Surg Case Rep. 3:385–388. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Yamao K, Kitano M, Kudo M and Maenishi O: Synchronous pancreatic and gastric metastasis from an ovarian adenocarcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration. Endoscopy. 47 Suppl 1:UCTN. E596–E597. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Antonini F, Laterza L, Fuccio L, Marcellini M, Angelelli L, Calcina S, Rubini C and Macarri G: Gastric metastasis from ovarian adenocarcinoma presenting as a subepithelial tumor and diagnosed by endoscopic ultrasound-guided tissue acquisition. World J Gastrointest Oncol. 9:452–456. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Yao K, Anagnostopoulos GK and Ragunath K: Magnifying endoscopy for diagnosing and delineating early gastric cancer. Endoscopy. 41:462–467. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Rajravelu RK and Ginsberg GG: Management of gastric GI stromal tumors: Getting the GIST of it. Gastrointest Endosc. 91:823–825. 2020. View Article : Google Scholar : PubMed/NCBI

23 

O'Toole D and Palazzo L: Endoscopy and endoscopic ultrasound in assessing and managing neuroendocrine neoplasms. Front Horm Res. 44:88–103. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Chu PG and Weiss LM: Keratin expression in human tissues and neoplasms. Histopathology. 40:403–439. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Merchant SH, Amin MB, Tamboli P, Ro J, Ordóñez NG, Ayala AG, Czerniak BA and Ro JY: Primary signet-ring cell carcinoma of lung: Immunohistochemical study and comparison with non-pulmonary signet-ring cell carcinomas. Am J Surg Pathol. 25:1515–1519. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Sheppard MN: Specific markers for pulmonary tumours. Histopathology. 36:273–276. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Rossi G, Marchioni A, Romagnani E, Bertolini F, Longo L, Cavazza A and Barbieri F: Primary lung cancer presenting with gastrointestinal tract involvement: Clinicopathologic and immunohistochemical features in a series of 18 consecutive cases. J Thorac Oncol. 2:115–120. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Thandra KC and Barsouk A, Saginala K, Aluru JS and Barsouk A: Epidemiology of lung cancer. Contemp Oncol (Pozn). 25:45–52. 2021.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang M, Zhang W, Fu C, Guan J, Ni X and Yao F: Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases. Oncol Lett 25: 228, 2023.
APA
Wang, M., Zhang, W., Fu, C., Guan, J., Ni, X., & Yao, F. (2023). Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases. Oncology Letters, 25, 228. https://doi.org/10.3892/ol.2023.13814
MLA
Wang, M., Zhang, W., Fu, C., Guan, J., Ni, X., Yao, F."Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases". Oncology Letters 25.6 (2023): 228.
Chicago
Wang, M., Zhang, W., Fu, C., Guan, J., Ni, X., Yao, F."Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases". Oncology Letters 25, no. 6 (2023): 228. https://doi.org/10.3892/ol.2023.13814
Copy and paste a formatted citation
x
Spandidos Publications style
Wang M, Zhang W, Fu C, Guan J, Ni X and Yao F: Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases. Oncol Lett 25: 228, 2023.
APA
Wang, M., Zhang, W., Fu, C., Guan, J., Ni, X., & Yao, F. (2023). Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases. Oncology Letters, 25, 228. https://doi.org/10.3892/ol.2023.13814
MLA
Wang, M., Zhang, W., Fu, C., Guan, J., Ni, X., Yao, F."Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases". Oncology Letters 25.6 (2023): 228.
Chicago
Wang, M., Zhang, W., Fu, C., Guan, J., Ni, X., Yao, F."Endoscopic manifestations and treatment outcomes of asymptomatic gastric metastases from primary lung adenocarcinoma: Report of two cases". Oncology Letters 25, no. 6 (2023): 228. https://doi.org/10.3892/ol.2023.13814
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