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June-2023 Volume 25 Issue 6

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Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)

  • Authors:
    • Chunlin Wang
    • Hao Zhang
    • Yunxiao Liu
    • Yuliuming Wang
    • Hanqing Hu
    • Guiyu Wang
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    Affiliations: Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China
  • Article Number: 230
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    Published online on: April 18, 2023
       https://doi.org/10.3892/ol.2023.13816
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Abstract

Colorectal cancer (CRC) is a malignant tumor and a major cause of morbidity and mortality globally. The classic Tumor‑Node‑Metastasis staging system, which currently underlies the diagnosis and treatment of CRC, is primarily a ‘one drug fits all’ model for patients exhibiting the same pathological features. However, a high degree of variability has been established in the long‑term survival outcomes of patients with CRC with similar pathological types and stages, which can be partially attributed to tumor‑specific molecular biology to some extent. Molecular classification of CRC can further assist with understanding the biological behavior of tumor genesis, development and prognosis, and assist clinicians in improving or customizing the treatment strategy of CRC. In the present study, clinical studies carried out to date are reviewed, and their clinical value is discussed. A multilevel overview of the major molecular types of CRC is provided, in the hope that investigators are encouraged to combine multiple omics studies for interrogating cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Zhang H, Liu Y, Wang Y, Hu H and Wang G: Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review). Oncol Lett 25: 230, 2023.
APA
Wang, C., Zhang, H., Liu, Y., Wang, Y., Hu, H., & Wang, G. (2023). Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review). Oncology Letters, 25, 230. https://doi.org/10.3892/ol.2023.13816
MLA
Wang, C., Zhang, H., Liu, Y., Wang, Y., Hu, H., Wang, G."Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)". Oncology Letters 25.6 (2023): 230.
Chicago
Wang, C., Zhang, H., Liu, Y., Wang, Y., Hu, H., Wang, G."Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)". Oncology Letters 25, no. 6 (2023): 230. https://doi.org/10.3892/ol.2023.13816
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Zhang H, Liu Y, Wang Y, Hu H and Wang G: Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review). Oncol Lett 25: 230, 2023.
APA
Wang, C., Zhang, H., Liu, Y., Wang, Y., Hu, H., & Wang, G. (2023). Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review). Oncology Letters, 25, 230. https://doi.org/10.3892/ol.2023.13816
MLA
Wang, C., Zhang, H., Liu, Y., Wang, Y., Hu, H., Wang, G."Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)". Oncology Letters 25.6 (2023): 230.
Chicago
Wang, C., Zhang, H., Liu, Y., Wang, Y., Hu, H., Wang, G."Molecular subtyping in colorectal cancer: A bridge to personalized therapy (Review)". Oncology Letters 25, no. 6 (2023): 230. https://doi.org/10.3892/ol.2023.13816
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