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June-2023 Volume 25 Issue 6

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Case Report Open Access

Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report

  • Authors:
    • Kyoung Min Kim
    • Ae Ri Ahn
    • Yong Tae Hong
    • Myoung Ja Chung
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Jeonbuk National University Medical School, Jeonbuk National University, Jeonju, Jeollabuk 54896, Republic of Korea, Department of Otolaryngology‑HNS, Jeonbuk National University Medical School, Jeonju, Jeollabuk 54896, Republic of Korea, Department of Pathology, Jeonbuk National University Medical School, Jeonbuk National University, Jeonju, Jeollabuk 54896, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 233
    |
    Published online on: April 18, 2023
       https://doi.org/10.3892/ol.2023.13819
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Abstract

Primary small cell thyroid carcinomas are extremely rare and there is still debate about their classification as a distinct disease entity. The present case report reports a small cell carcinoma (SCC) combined with poorly differentiated thyroid carcinoma (PDTC) in a 34 year old man. The tumor consisted of ~80% PDTC and ~20% SCC. The PDTC component was positive for cytokeratin and thyroid transcription factor‑1 (TTF‑1), and negative for calcitonin, chromogranin and synaptophysin. The SCC component was positive for synaptophysin and CD56, and negative for calcitonin, chromogranin and TTF‑1. Seven months after thyroid surgery, two new lung nodules were detected. Histologically and immunohistochemically, the lung tumors were similar to the SCC component of the thyroid carcinoma. The mutational status of cancer‑related genes was assessed using targeted next‑generation sequencing in both the thyroid and lung, which identified similar genetic alterations. The histogenesis of SCC was evaluated through NGS analysis of the two cancer components.
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Copy and paste a formatted citation
Spandidos Publications style
Kim K, Ahn A, Hong Y and Chung M: Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report. Oncol Lett 25: 233, 2023.
APA
Kim, K., Ahn, A., Hong, Y., & Chung, M. (2023). Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report. Oncology Letters, 25, 233. https://doi.org/10.3892/ol.2023.13819
MLA
Kim, K., Ahn, A., Hong, Y., Chung, M."Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report". Oncology Letters 25.6 (2023): 233.
Chicago
Kim, K., Ahn, A., Hong, Y., Chung, M."Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report". Oncology Letters 25, no. 6 (2023): 233. https://doi.org/10.3892/ol.2023.13819
Copy and paste a formatted citation
x
Spandidos Publications style
Kim K, Ahn A, Hong Y and Chung M: Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report. Oncol Lett 25: 233, 2023.
APA
Kim, K., Ahn, A., Hong, Y., & Chung, M. (2023). Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report. Oncology Letters, 25, 233. https://doi.org/10.3892/ol.2023.13819
MLA
Kim, K., Ahn, A., Hong, Y., Chung, M."Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report". Oncology Letters 25.6 (2023): 233.
Chicago
Kim, K., Ahn, A., Hong, Y., Chung, M."Primary small cell thyroid carcinoma combined with poorly differentiated thyroid carcinoma, evidence for a common origin: A case report". Oncology Letters 25, no. 6 (2023): 233. https://doi.org/10.3892/ol.2023.13819
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