Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2023 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2023 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report

  • Authors:
    • Liwei Ren
    • Wenhui Liu
    • Tao Wu
    • Feng Xue
    • Dongfeng Mao
    • Lingling Yu
    • Hai Bai
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The 940th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Lanzhou, Gansu 730050, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 237
    |
    Published online on: April 19, 2023
       https://doi.org/10.3892/ol.2023.13823
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study reports the case of a patient with diffuse large B‑cell lymphoma (DLBCL) and monoclonal gammopathy (MG) secondary to immune thrombocytopenia purpura (ITP). The clinical diagnoses and investigations of this case are reported. To the best of our knowledge, this is the first study to report DLBCL and MG secondary to ITP. The patient presented with a rare constellation of diseases, which made the diagnosis and treatment difficult for the physicians. The patient was followed up for 10 years using the morphological examination of bone marrow cells after chemotherapy, and currently continues with follow‑up examinations. Treatments and prognoses for ITP, DLBCL and MG are common. However, treatments and prognoses are unclear for patients with all three conditions. The different clinical manifestations and disease processes of DLBCL and MG secondary to ITP cause difficulties for physicians in terms of treatment and prognosis. The present case report describes the comprehensive evaluation, diagnosis and treatment of a patient with DLBCL and MG secondary to, and concurrent with, ITP.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Fattizzo B and Barcellini W: Autoimmune cytopenias in chronic lymphocytic leukemia: Focus on molecular aspects. Front Oncol. 9:14352020. View Article : Google Scholar : PubMed/NCBI

2 

Barcellini W, Capalbo S, Agostinelli RM, Mauro FR, Ambrosetti A, Calori R, Cortelezzi A, Laurenti L, Pogliani EM, Pedotti P, et al: Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia. Haematologica. 91:1689–1692. 2006.PubMed/NCBI

3 

Fallah M, Liu X, Ji J, Försti A, Sundquist K and Hemminki K: Autoimmune diseases associated with non-Hodgkin lymphoma: A nationwide cohort study. Ann Oncol. 25:2025–2030. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Visco C, Ruggeri M, Laura Evangelista M, Stasi R, Zanotti R, Giaretta I, Ambrosetti A, Madeo D, Pizzolo G and Rodeghiero F: Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia. Blood. 111:1110–1116. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Mittal S, Blaylock MG, Culligan DJ, Barker RN and Vickers MA: A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura. Haematologica. 93:151–152. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Kyle RA and Lust JA: Monoclonal gammopathies of undetermined significance. Semin Heamatol. 26:176–200. 1989.PubMed/NCBI

7 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Liu Y and Barta SK: Diffuse large B-cell lymphoma: 2019 Update on diagnosis, risk stratification, and treatment. Am J Hematol. 94:604–616. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Papageorgiou SG, Thomopoulos TP, Spathis A, Bouchla A, Glezou I, Stavroulaki G, Gkontopoulos K, Bazani E, Foukas PG and Pappa V: Prognostic significance of monoclonal gammopathy in diffuse large B-cell lymphoma. Hematol Oncol. 37:634–637. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA and Bloomfield CD: World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the clinical advisory committee meeting. Airlie House, Virginia, November 1997. J Clin Oncol. 17:3835–3849. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Müller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, et al: Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 103:275–282. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Cooper N: State of the art-how I manage immune thrombocytopenia. Br J Haematol. 177:39–54. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zufferey A, Kapur R and Semple JW: Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP). J Clin Med. 6:162017. View Article : Google Scholar : PubMed/NCBI

14 

Olsson B, Ridell B, Jernås M and Wadenvik H: Increased number of B-cells in the red pulp of the spleen in ITP. Ann Hematol. 91:271–277. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Chen JF, Yang LH, Chang LX, Feng JJ and Liu JQ: The clinical significance of circulating B cells secreting anti-glycoprotein IIb/IIIa antibody and platelet glycoprotein IIb/IIIa in patients with primary immune thrombocytopenia. Hematology. 17:283–290. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Li X, Zhong H, Bao W, Boulad N, Evangelista J, Haider MA, Bussel J and Yazdanbakhsh K: Defective regulatory B-cell compartment in patients with immune thrombocytopenia. Blood. 120:3318–3325. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Aslam R, Segel GB, Burack R, Spence SA, Speck ER, Guo L and Semple JW: Splenic lymphocyte subtypes in immune thrombocytopenia: Increased presence of a subtype of B-regulatory cells. Br J Haematol. 173:159–160. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Min YN, Wang CY, Li XX, Hou Y, Qiu JH, Ma J, Shao LL, Zhang X, Wang YW, Peng J, et al: Participation of B-cell-activating factor receptors in the pathogenesis of immune thrombocytopenia. J Thromb Haemost. 14:559–571. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Miltiadous O, Hou M and Bussel JB: Identifying and treating refractory ITP: Difficulty in diagnosis and role of combination treatment. Blood. 135:472–490. 2020. View Article : Google Scholar : PubMed/NCBI

20 

De Rossi G, Granati L, Girelli G, Gandolfo G, Arista MC, Martelli M, Conti L, Marini R, La Tagliata R, Leone R, et al: Incidence and prognostic significance of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL). Nouv Rev Fr Hematol (1978). 30:403–406. 1988.PubMed/NCBI

21 

De Rossi G, Granati L, Girelli G, Gandolo G, Perrone P, Martelli M, Conti L, Marini R, Pastorelli D, Coluzzi S, et al: Prognostic value of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL). Tumori. 77:100–104. 1991. View Article : Google Scholar : PubMed/NCBI

22 

Garvey MB and Freedman J: Indirect platelet radioactive antiglobulin test in patients with lymphoproliferative disease. J Lab Clin Med. 107:123–128. 1986.PubMed/NCBI

23 

Liu EB, Zhang PH, Li ZQ, Sun Q, Yang QY, Fang LH, Sun FJ and Qiu LG: Clinicopathologic features of lymphoplasmacytic lymphoma. Zhonghua Bing Li Xue Za Zhi. 39:308–312. 2010.(In Chinese). PubMed/NCBI

24 

Lechman HA, Lehman LO, Rutagi PK, Rustgi RN, Plunkett RW, Farolino DL, Conway J and Logue GL: Complement-mediated autoimmune thrombocytopenia. Monoclonal IgM antiplatelet antibody associated with lymphoreticular malignant disease. N Engl J Med. 316:194–198. 1987.

25 

Kuznetsov AI, Ivanov AL, Idelson LI and Mazurov AV: Mechanisms of thrombocytopenia in patients with lymphoproliferative diseases. Eur J Haematol. 49:113–118. 1992. View Article : Google Scholar : PubMed/NCBI

26 

Myers TJ, Kim BK, Steiner M and Baldini MG: Platelet-associated complement C3 in immune thrombocytopenic purpura. Blood. 59:1023–1028. 1982. View Article : Google Scholar : PubMed/NCBI

27 

Kaiho T, Miyazaki M, Iinuma K, Ito H, Koyama T, Nakagawa K and Nakajima N: Long-term prognosis of idiopathic thrombocytopenic purpura treated by partial splenic embolization. Nihon Geka Gakkai Zasshi. 94:383–393. 1993.(In Japanese). PubMed/NCBI

28 

Vardhana SA, Sauter CS, Matasar MJ, Zelenetz AD, Galasso N, Woo KM, Zhang Z and Moskowitz CH: Outcomes of primary refractory diffuse large B-cell lymphoma (DLBCL) treated with salvage chemotherapy and intention to transplant in the rituximab era. Br J Haematol. 176:591–599. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Coiffier B, Thieblemont C, Van Den Neste E, Lepeu G, Plantier I, Castaigne S, Lefort S, Marit G, Macro M, Sebban C, et al: Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: A study by the Groupe d'Etudes des Lymphomes de l'Adulte. Blood. 116:2040–2045. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Witzig TE, Maurer MJ, Stenson MJ, Allmer C, Macon W, Link B, Katzmann JA and Gupta M: Elevated serum monoclonal and polyclonal free light chains and interferon inducible protein-10 predicts inferior prognosis in untreated diffuse large B-cell lymphoma. Am J Hematol. 89:417–422. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Kaseb H, Annamaraju P and Babiker HM: Monoclonal gammopathy of undetermined significance. StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2023

32 

Wright DH: Malignant lymphomas other than Hodgkin's disease: Histology, cytology, ultrastructure, immunology. J Clin Pathol. 32:4141979. View Article : Google Scholar : PubMed/NCBI

33 

Economopoulos T, Papageorgiou S, Pappa V, Papageorgiou E, Valsami S, Kalantzis D, Xiros N, Dervenoulas J and Raptis S: Monoclonal gammopathies in B-cell non-Hodgkin's lymphomas. Leuk Res. 27:505–508. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Kim YR, Kim SJ, Cheong JW, Kim Y, Jang JE, Lee JY, Min YH, Song JW, Yang WI and Kim JS: Monoclonal and polyclonal gammopathy measured by serum free light chain and immunofixation subdivide the clinical outcomes of diffuse large B-cell lymphoma according to molecular classification. Ann Hematol. 93:1867–1877. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Li Y, Wang L, Zhu HY, Liang JH, Wu W, Wu JZ, Xia Y, Fan L, Li JY and Xu W: Prognostic significance of serum immunoglobulin paraprotein in patients with diffuse large B cell lymphoma. Br J Haematol. 182:131–134. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Zhang Y, Wei Z, Li J, Gao R and Liu P: Monoclonal gammopathies regardless of subtypes are associated with poor prognosis of diffuse large B-cell lymphoma: A STROBE-compliant article. Medicine (Baltimore). 97:e117192018. View Article : Google Scholar : PubMed/NCBI

37 

Cox MC, Di Napoli A, Fabbri A, Cencini E and Ruco L: The significance of serum immunoglobulin paraprotein in diffuse large B-cell lymphoma. Br J Haematol. 182:741–742. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ren L, Liu W, Wu T, Xue F, Mao D, Yu L and Bai H: Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report. Oncol Lett 25: 237, 2023.
APA
Ren, L., Liu, W., Wu, T., Xue, F., Mao, D., Yu, L., & Bai, H. (2023). Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report. Oncology Letters, 25, 237. https://doi.org/10.3892/ol.2023.13823
MLA
Ren, L., Liu, W., Wu, T., Xue, F., Mao, D., Yu, L., Bai, H."Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report". Oncology Letters 25.6 (2023): 237.
Chicago
Ren, L., Liu, W., Wu, T., Xue, F., Mao, D., Yu, L., Bai, H."Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report". Oncology Letters 25, no. 6 (2023): 237. https://doi.org/10.3892/ol.2023.13823
Copy and paste a formatted citation
x
Spandidos Publications style
Ren L, Liu W, Wu T, Xue F, Mao D, Yu L and Bai H: Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report. Oncol Lett 25: 237, 2023.
APA
Ren, L., Liu, W., Wu, T., Xue, F., Mao, D., Yu, L., & Bai, H. (2023). Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report. Oncology Letters, 25, 237. https://doi.org/10.3892/ol.2023.13823
MLA
Ren, L., Liu, W., Wu, T., Xue, F., Mao, D., Yu, L., Bai, H."Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report". Oncology Letters 25.6 (2023): 237.
Chicago
Ren, L., Liu, W., Wu, T., Xue, F., Mao, D., Yu, L., Bai, H."Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report". Oncology Letters 25, no. 6 (2023): 237. https://doi.org/10.3892/ol.2023.13823
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team