Multiple myeloma in a patient with chronic myeloid leukemia: A case report

  • Authors:
    • Xiao-Lan Li
    • Min Li
    • Ling-Zhi Wang
    • Min Liang
    • Juan Tian
    • Zi-Wei Shi
    • Kui Song
  • View Affiliations

  • Published online on: April 20, 2023     https://doi.org/10.3892/ol.2023.13830
  • Article Number: 244
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Abstract

Chronic myeloid leukemia (CML), a clonal myeloproliferative disorder of pluripotent hematopoietic stem cells, results from the Philadelphia chromosome (Ph) chromosome. The Ph is from a translocation, t(9;22)(q34q11), that creates a BCR‑ABL fusion gene, which is transcribed into proteins with abnormal tyrosine kinase activity, driving the abnormal proliferation of white blood cells. Multiple myeloma (MM) is a proliferation disorder of plasma cells derived from a single clone, which may lead to uncontrolled growth, kidney injury, destructive bone lesions, hypercalcemia and anemia. It is extremely rare that MM and CML should occur in the same patient either synchronously or metachronously. To date, MM accompanied with CML has only been reported in limited studies, and the the cause behind the occurrence of both malignancies together is not understood. With the advent of novel therapies, the survival time in patients with CML and MM has improved. Therefore, the further investigation of the pathophysiology and clinical characteristics of these cases is valuable. The present study reports the case of a 79‑year‑old male who had been diagnosed with CML and treated with tyrosine kinase inhibitor, and then developed immunoglobulin G‑κ MM after 6 years. This report should provide valid raw data for clinical research.
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June-2023
Volume 25 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li X, Li M, Wang L, Liang M, Tian J, Shi Z and Song K: Multiple myeloma in a patient with chronic myeloid leukemia: A case report. Oncol Lett 25: 244, 2023
APA
Li, X., Li, M., Wang, L., Liang, M., Tian, J., Shi, Z., & Song, K. (2023). Multiple myeloma in a patient with chronic myeloid leukemia: A case report. Oncology Letters, 25, 244. https://doi.org/10.3892/ol.2023.13830
MLA
Li, X., Li, M., Wang, L., Liang, M., Tian, J., Shi, Z., Song, K."Multiple myeloma in a patient with chronic myeloid leukemia: A case report". Oncology Letters 25.6 (2023): 244.
Chicago
Li, X., Li, M., Wang, L., Liang, M., Tian, J., Shi, Z., Song, K."Multiple myeloma in a patient with chronic myeloid leukemia: A case report". Oncology Letters 25, no. 6 (2023): 244. https://doi.org/10.3892/ol.2023.13830